Xigduo XR (Dapagliflozin Propanediol/Metformin Hydrochloride)

Name: Xigduo XR
Brand: AstraZeneca
SKU: 7066
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Xigduo XR Tablet

Manufacturer: AstraZeneca

Country: Australia

Dosage: 5 mg/1000 mg

Qty-Price (USD):

Type:

Product: Xigduo XR Tablet

Manufacturer: AstraZeneca

Country: India

Dosage: 10 mg/1000 mg

Qty-Price (USD):

Type:

Product: Xigduo XR Tablet

Manufacturer: AstraZeneca

Country: India

Dosage: 10 mg/500 mg

Qty-Price (USD):

Type:

Product: Xigduo XR Tablet

Manufacturer: AstraZeneca

Country: Australia

Dosage: 10 mg/1000 mg

Qty-Price (USD):

Type:

Product: Xigduo XR Tablet

Manufacturer: AstraZeneca

Country: Australia

Dosage: 10 mg/500 mg

Qty-Price (USD):

Generic Equivalent of Xigduo XR

Type

Product

Manufacturer

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Dosage

Qty-Price (USD)

There is no generic product of Xigduo XR.

Xigduo XR Information

medically reviewed by Carol Hou (BSc. Pharm) on October 17, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Xigduo XR and Dapagliflozin Propanediol/Metformin Hydrochloride at CanadaPharmacyOnline.com

Brand Xigduo is manufactured by AstraZeneca in Australia and India.

Generic dapagliflozin/metformin is currently unavailable (at this pharmacy).

Dosage:

The brand Xigduo XR is commonly available in oral extended-release tablets in the following strengths (at this pharmacy):
• 5 mg dapagliflozin/1000 mg metformin extended-release
• 10 mg dapagliflozin/500 mg metformin extended-release
• 10 mg dapagliflozin/1000 mg metformin extended-release

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Xigduo XR is a prescription medication used to treat type 2 diabetes and control blood sugar in adults. Xigduo XR lowers blood sugar by removing excess sugar and helping the body utilize the sugar it has. It's essential to remember that this medication works most effectively when combined with a healthy diet and regular physical activity.

Mechanism of Action: Xigduo XR contains two medications, dapagliflozin and metformin, that work together to lower your blood sugar if you have type 2 diabetes. Dapagliflozin helps your body eliminate excess sugar by causing your kidneys to release it through your urine. At the same time, metformin helps your body use the sugar it already has more effectively. It achieves this by reducing the amount of sugar your liver produces and enhancing your body's response to insulin, allowing your cells to absorb more sugar. By combining these methods, Xigduo XR effectively lowers your blood sugar levels throughout the day. This medication is most effective when used as part of a comprehensive treatment plan that includes a healthy diet and regular physical activity.

Take Xigduo XR exactly as prescribed by your doctor, following the instructions in the Details for: Xigduo - Drug and Health Product Register. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Xigduo XR, it is essential to discuss all possible effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Xigduo XR (Dapagliflozin Propanediol/Metformin Hydrochloride). It is not an exhaustive list, and individual reactions can vary.

Common side effects – The following are some common side effects of Xigduo XR; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea
• Genital yeast infections (in both men and women)
• Headache
• Nasal congestion, runny nose, or sore throat
• Nausea
• Urinary tract infections (UTIs)

Other Potential Side Effects (less common):
• Back pain
• Constipation
• Cough
• Dizziness
• Stomach pain
• Urinating more often

Serious or rare side effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any signs of an allergic reaction, such as:
• Allergic reactions, including hives, swelling of the face, lips, tongue, or throat, and difficulty breathing
• Dehydration, which may lead to feeling dizzy, lightheaded, or faint
• Diabetic ketoacidosis (a build-up of ketones in the blood)
• Fournier's gangrene (a rare but serious infection of the genital area)
• Lactic acidosis (a dangerous build-up of lactic acid in the blood)
• Low blood sugar (hypoglycemia), especially if taken with other diabetes medications like insulin or a sulfonylurea
• Vitamin B12 deficiency

Contraindications:

The following is not an exhaustive list of contraindications. Before taking Xigduo XR, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Xigduo XR should not be used under the following conditions:
• Acute or Chronic Metabolic Acidosis, including Diabetic Ketoacidosis (DKA).
• Conditions that predispose to Lactic Acidosis, such as severe heart failure or severe hepatic impairment.
• Known Hypersensitivity to dapagliflozin, metformin, or any of the excipients.
• Severe Renal Impairment (eGFR < 30 mL/min / 1.73 m2).
• Type 1 Diabetes Mellitus.
• Undergoing Radiological Studies with Iodinated Contrast (Metformin must be temporarily stopped).

Drug Interactions:

Before taking Xigduo XR, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official prescribing information from AstraZeneca-us.com at https://www.azpicentral.com/pi.html?product=xigduoxr.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. Xigduo XR may interact with the following:
• Interactions Related to Metformin (Risk of Lactic Acidosis)
o Cationic Drugs (e.g., Cimetidine, Ranolazine, Trimethoprim): These can interfere with how metformin is cleared by the kidneys, which may increase metformin levels and raise the risk of lactic acidosis.
o Drugs That Increase the Risk of Lactic Acidosis: Certain medications, especially those that impair renal function, increase the risk of lactic acidosis when taken with metformin. These include Carbonic anhydrase inhibitors (e.g., topiramate, zonisamide) and drugs that impair renal function (e.g., NSAIDs).
• Interactions Related to Dapagliflozin (Risk of Dehydration/Hypotension)
o Diuretics (e.g., Loop and Thiazide diuretics): Dapagliflozin increases urination, and combining it with other diuretics can increase the risk of dehydration and hypotension.
o Lithium: Dapagliflozin may decrease lithium levels due to increased fluid excretion, so lithium levels should be monitored.
• Interactions Related to Glycemic Control (Risk of Hypoglycemia or Hyperglycemia)
o Drugs That Affect Glycemic Control (e.g., Corticosteroids, Thiazide diuretics, Estrogens, Thyroid products): These medications can raise blood sugar levels, requiring dose adjustments of Xigduo XR.
o Insulin and Insulin Secretagogues (e.g., Sulfonylureas): Combining Xigduo XR with these can significantly increase the risk of hypoglycemia. A lower dose of insulin or the insulin secretagogue may be required.
o Other Glucose-Lowering Medications: When taken with other diabetes medications, the risks of hypoglycemia can be increased.

Pregnancy and Breastfeeding

If you're pregnant, planning to get pregnant, or breastfeeding, Xigduo XR isn't the correct medicine for you. Doctors usually recommend alternative methods to manage blood sugar levels during pregnancy, such as insulin injections. This is because we want to ensure your baby's safety. Also, we don't know if the medicine passes into breast milk, so it's best to avoid it while breastfeeding. If you're thinking about having a baby or are already pregnant or breastfeeding, talk to your doctor right away. They can help you find a safe way to manage your diabetes.

Use in Children:

Xigduo XR (dapagliflozin and metformin extended-release) is now approved for use in children and adolescents aged 10 years and older as an adjunct to diet and exercise to improve glycemic control in Type 2 Diabetes Mellitus.

It is not approved for use in children younger than 10 years of age, as its safety and effectiveness have not been established in this younger group. Since Xigduo XR combines two medications, dapagliflozin and metformin, doctors cannot assume it is safe, even though metformin is commonly used in children 10 and older. If a child needs these medications, a healthcare provider will typically prescribe the individual components separately or choose other approved therapies, such as insulin or metformin alone, to ensure the safest and most effective management of their diabetes.

Use in Older Adults:

Using Xigduo XR in older adults (age 65 and over) requires extra caution and close medical supervision, but it is often suitable. This is mainly because older adults have a higher risk of decreased kidney function, which is essential for clearing both medications from the body. If kidney function declines, the risk of a rare but serious side effect called lactic acidosis increases, and the medication may need to be stopped if kidney function drops too low. Additionally, the dapagliflozin component can cause dehydration and low blood pressure, which can increase the risk of dizziness and falls. Therefore, your doctor will need to monitor your kidney function and hydration more closely while you are on this medication.

Frequently Asked Questions about Xigduo XR at Canada Pharmacy Online:

Why is Aldara Cream Pump Spray more affordable in Canada than in the United States?

Prescription drug prices, including Xigduo XR, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering Xigduo XR from us is very simple. You can place the order online or call Customer Service at 1866.920.3784. For additional information or to initiate the ordering process, please visit our How to Order page.

Is there a limit on the number of Xigduo XR tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Xigduo XR at one time, as per your doctor's prescription.

Can I buy Xigduo XR over the counter from you?

No, Xigduo XR requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Xigduo XR?

No, there is currently no generic alternative available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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