Xigduo (Dapagliflozin Propanediol Monohydrate/Metformin Hydrochloride)

Name: Xigduo
Brand: AstraZeneca
SKU: 7316
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Xigduo Tablet

Manufacturer: AstraZeneca

Country: Canada

Dosage: 5 mg/1000 mg

Qty-Price (USD):

Type:

Product: Xigduo Tablet

Manufacturer: AstraZeneca

Country: Canada

Dosage: 5 mg/850 mg

Qty-Price (USD):

Generic Equivalent of Xigduo

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Dapagliflozin Propanediol Monohydrate/Metformin Hydrochloride Tablet

Manufacturer: Generic

Country: Canada

Dosage: 5 mg/1000 mg

Qty-Price (USD):

Type:

Product: Dapagliflozin Propanediol Monohydrate/Metformin Hydrochloride Tablet

Manufacturer: Generic

Country: Canada

Dosage: 5 mg/850 mg

Qty-Price (USD):

Xigduo Information

medically reviewed by Carol Hou (BSc. Pharm) on November 20, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Xigduo and Dapagliflozin Propanediol Monohydrate/Metformin Hydrochloride at CanadaPharmacyOnline.com

The brand Xigduo is manufactured by AstraZeneca in Canada.

Generic dapagliflozin propanediol monohydrate/metformin hydrochloride hemifumarate is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Dapagliflozin Propanediol Monohydrate/Metformin Hydrochloride

Generic dapagliflozin propanediol monohydrate/metformin hydrochloride hemifumarate contains the same active ingredients as brand-name Xigduo and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in a similar way to Xigduo. Studies have shown that generic dapagliflozin propanediol monohydrate/metformin hydrochloride hemifumarate is bioequivalent to brand-name Xigduo, meaning it has a similar absorption rate and reaches identical concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Usage:

Xigduo (dapagliflozin and metformin HCl extended-release) is a prescription medication that is used to treat Type 2 Diabetes Mellitus in adults and children aged 10 and older. It also helps lower the risk of worsening kidney disease and cardiovascular death in adults with chronic kidney disease. It’s essential to remember that this medication works most effectively when combined with a healthy diet and regular physical activity.

Mechanism of Action:
Xigduo works through two mechanisms, combining the active ingredients dapagliflozin and metformin. Metformin primarily reduces the amount of sugar your liver produces (hepatic gluconeogenesis) and helps your body's cells become more responsive to insulin, allowing them to absorb more sugar from the blood. (It also has a minor effect on reducing glucose absorption from the gastrointestinal tract.) At the same time, dapagliflozin affects the kidneys by blocking the SGLT2 protein, which generally helps recycle sugar back into the blood. When this protein is blocked, dapagliflozin causes excess sugar to be removed from your body and excreted in urine. These two actions together powerfully and effectively lower blood sugar levels in adults and pediatric patients aged 10 and older with Type 2 Diabetes.

Take Xigduo exactly as prescribed by your doctor, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Xigduo, it is essential to discuss all possible effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Xigduo (dapagliflozin and metformin hydrochloride). It is not an exhaustive list, and individual reactions can vary.

Common side effects – The following are some common side effects of Xigduo; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea
• Female genital yeast infections (e.g., vaginal discharge, itching)
• Headache
• Increased urination
• Influenza (flu-like symptoms)
• Male genital yeast infections (e.g., redness, itching, swelling of the penis)
• Nausea
• Nasopharyngitis (common cold symptoms, runny/stuffy nose, sore throat)
• Upper respiratory tract infection
• Urinary tract infection (UTI)
• Vomiting

Other Potential Side Effects (less common):
• Back pain
• Constipation
• Cough
• Decreased appetite
• Dizziness
• Dyslipidemia (abnormal cholesterol or fat levels in the blood)
• Increased thirst
• Pain in extremities (arms, legs, hands, or feet)

Serious or rare side effects: These are rare but potentially severe side effects of Xigduo. Seek immediate medical attention or call emergency services if you experience any signs of an allergic reaction, such as:
• Allergic reaction: Hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
• Dehydration/Volume Depletion: Feeling dizzy, lightheaded, or faint, especially when standing up; or signs of kidney problems (e.g., decreased urination).
• Diabetic Ketoacidosis (DKA): Nausea, vomiting, stomach pain, confusion, unusual drowsiness, or a sweet/fruity smell to the breath. (This can occur even with normal blood sugar levels.)
• Fournier's Gangrene (Necrotizing Fasciitis of the Perineum): Severe pain, tenderness, redness, or swelling of the genital or anal area, accompanied by fever or a general feeling of being unwell.
• Hypoglycemia (Low Blood Sugar): Especially when Xigduo is taken with insulin or a sulfonylurea; symptoms include sudden sweating, shaking, fast heartbeat, hunger, or confusion.
• Lactic Acidosis (a build-up of lactic acid in the blood, often a medical emergency): Unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, feeling cold, or feeling very weak or tired.

Contraindications:

The following is not an exhaustive list of contraindications. Before taking Xigduo, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Xigduo should not be used under the following conditions:
• Hypersensitivity/Allergy: A known allergic reaction to dapagliflozin, metformin, or any other ingredient in Xigduo.
• Lactic Acidosis History: A previous history of this rare but serious complication.
• Metabolic Acidosis: Presence of acute or chronic metabolic acidosis, including Diabetic Ketoacidosis (DKA).
• Severe Hepatic Impairment: Significant liver issues (a standard contraindication for the metformin component).
• Severe Renal Impairment (estimated GFR < 30 mL/min/1.73 m^2), End-Stage Renal Disease (ESRD), or being on dialysis.
• Type 1 Diabetes Mellitus: Use is not recommended due to a high risk of DKA in this population.

Tell your doctor about any medical conditions you have, past and present, before starting Xigduo. This is important because certain conditions might influence whether Xigduo is suitable for you. These conditions may include, but are not limited to:
• Dehydration/Volume Depletion Risk: Conditions that predispose you to dehydration, like being elderly, or frequent, severe vomiting or diarrhea.
• Excessive alcohol intake (acute or chronic), as it increases the risk of lactic acidosis
• Genital or Urinary Tract Infections (UTIs): Xigduo can increase the risk of serious UTIs, including kidney infections and a rare, severe genital infection called Fournier's Gangrene.
• Heart Problems: Especially unstable congestive heart failure or conditions that increase the risk of tissue hypoxia (low oxygen).
• Pancreatic Problems: A history of pancreatitis or other conditions affecting the pancreas.
• Recent or Planned Procedures:
o Any major surgery (the drug must be stopped temporarily).
o Any procedure using iodinated contrast media (like a CT scan or X-ray dye)—the drug must be stopped before or at the time of the procedure.

Drug Interactions:

Before starting Xigduo, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official product monograph from AstraZeneca Canada at https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/xigduo-product-monograph-en.pdf.

Provide your doctor with a complete list of all your medications, including prescription, over-the-counter drugs, vitamins, and herbal supplements. Xigduo may interact with the following:

Interactions that Increase the Risk of Lactic Acidosis
Combining Xigduo with these items can cause the Metformin component to build up to dangerous levels.
• Acid-Altering Medications: Drugs like acetazolamide or topiramate can disrupt the body's acid balance, further increasing the risk of Lactic Acidosis.
• Alcohol: Excessive alcohol intake (especially binge drinking or chronic use) should be strictly avoided as it dramatically increases the risk of Lactic Acidosis.
• Iodinated Contrast Media (Dyes for Scans): If you are scheduled for a CT scan or X-ray that involves injecting an iodine dye, you must stop Xigduo before the procedure. Your doctor will confirm that your kidney function is normal before you restart the medication, as the dye can temporarily strain your kidneys.
• Kidney-Altering Medications: Drugs that are eliminated by the same kidney pathways as metformin can cause metformin to build up. Examples include Cimetidine (Tagamet), the antibiotic Trimethoprim, Ranolazine, and Vancomycin.

Interactions Affecting Fluid and Blood Sugar Levels
These interactions require close monitoring and potential dose adjustments by your doctor to prevent sugar imbalances or severe dehydration.
• Diuretics ("Water Pills"): Taking Xigduo with diuretics (e.g., Furosemide, Hydrochlorothiazide) is risky because both make you lose fluid. This "double-whammy" can lead to excessive fluid loss, low blood pressure, and potentially acute kidney injury.
• Insulin and Insulin Secretagogues: When Xigduo is combined with drugs that force the body to produce insulin (like Glipizide or Glimepiride) or insulin itself, the risk of low blood sugar (hypoglycemia) increases. Your doctor will likely need to lower the dose of the insulin or secretagogue.
• Medications that Raise Blood Sugar: Drugs such as corticosteroids (e.g., prednisone), thyroid products (e.g., levothyroxine), and certain hormones (e.g., oral contraceptives) can raise blood sugar, potentially working against the effects of Xigduo. These combinations require careful monitoring.

Pregnancy and Breastfeeding:

During Pregnancy: Xigduo is generally not recommended, especially after the first trimester.met), the antibiotic Trimethoprim, Ranolazine, and Vancomycin.
• The drug contains dapagliflozin, which has been shown to potentially harm a baby's developing kidneys during the second and third trimesters.met), the antibiotic Trimethoprim, Ranolazine, and Vancomycin.
• Your doctor will likely switch you to insulin, which is the standard, safest drug for controlling blood sugar during pregnancy.

While Breastfeeding: Xigduo is not advised.
• We don't know exactly how much of the medication passes into breast milk. Still, there is a theoretical risk that the dapagliflozin component could interfere with the infant's kidney development or blood sugar.
• The risk is considered high enough that you should discontinue Xigduo or discontinue nursing.

se in Children:

Xigduo is considered safe and is approved for use in children and adolescents aged 10 years and older. The safety profile in this age group is similar to that in adults. However, it is essential to remember that Xigduo is not meant for children with Type 1 Diabetes, and a healthcare professional must carefully determine the correct dose and monitor the child for potential side effects, such as dehydration and genital yeast infections.

Use in Older Adults:

For older adults (aged 65 and over), Xigduo (dapagliflozin and metformin) can be used safely, though it requires heightened caution and frequent monitoring by a healthcare provider. The primary concern is that a natural age-related decline in kidney function increases two key risks: a greater risk of the rare complication lactic acidosis (due to the metformin component) and reduced overall effectiveness, as both drugs rely on the kidneys. Consequently, regular kidney function tests are non-negotiable for dose adjustments. Furthermore, the dapagliflozin component can cause dehydration, and because older adults are already more susceptible to this—especially if they are also taking diuretics—monitoring for symptoms like dizziness or lightheadedness is essential to ensure their safety.

Frequently Asked Questions about Xigduo at Canada Pharmacy Online:

Why is Xigduo more affordable in Canada than in the United States?

Prescription drug prices, including Xigduo, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is committed to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering Xigduo from us is very simple. You can place the order online or call Customer Service at 1866.920.3784. For additional information or to initiate the ordering process, please visit our How to Order page.

Is there a limit on the number of Xigduo tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Xigduo at one time, as per your doctor's prescription.

Can I buy Xigduo over the counter from you?

No, Xigduo requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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