Zocor (Simvastatin)

Name: Zocor
Brand: Merck
SKU: 2239
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Zocor

Manufacturer: Merck

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Zocor (ON BACKORDER)

Manufacturer: Merck

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Zocor

Manufacturer: Merck

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Zocor

Manufacturer: Merck

Country: Australia

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Zocor (ON BACKORDER)

Manufacturer: Merck

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Zocor

Manufacturer: Merck

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Zocor

Manufacturer: Merck

Country: Australia

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Zocor (ON BACKORDER)

Manufacturer: Merck

Country: United Kingdom

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Zocor (ON BACKORDER)

Manufacturer: Merck

Country: United Kingdom

Dosage: 80 mg

Qty-Price (USD):

Generic Equivalent of Zocor

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Simvastatin

Manufacturer: Generic

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Simvastatin

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Simvastatin

Manufacturer: Generic

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Simvastatin

Manufacturer: Generic

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Simvastatin

Manufacturer: Generic

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Simvastatin

Manufacturer: Generic

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Simvastatin

Manufacturer: Generic

Country: United Kingdom

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Simvastatin

Manufacturer: Generic

Country: Canada

Dosage: 80 mg

Qty-Price (USD):

Type:

Product: Simvastatin (ON BACKORDER)

Manufacturer: Generic

Country: United Kingdom

Dosage: 80 mg

Qty-Price (USD):

Zocor Information

medically reviewed by Carol Hou (BSc. Pharm) on June 24, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Zocor and Simvastatin at CanadaPharmacyOnline.com

Brand Zocor (simvastatin) is manufactured by Merck in many countries worldwide, such as Canada, the United Kingdom, and Australia.

Generic simvastatin is sourced from manufacturers meeting applicable local regulatory standards. The specific manufacturer of dispensed medication may vary.

Important Information about Generic Simvastatin:

Generic simvastatin contains the same active ingredient as brand-name Zocor and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work the same way Zocor does. Studies have demonstrated bioequivalence between generic and brand-name simvastatin, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. Talk to your doctor or pharmacist, if you have any questions about using generic simvastatin.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

Brand Zocor and generic simvastatin are commonly available in 10 mg, 20 mg, 40 mg, and 80 mg oral tablets. Generic simvastatin may also be available in other strengths, such as 5 mg, depending on the manufacturer and region.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Zocor (simvastatin) is a prescription medication primarily used to reduce elevated total cholesterol (total-C) and low-density lipoprotein cholesterol (LDL-C) in patients with various forms of primary hyperlipidemia, such as heterozygous familial hypercholesterolemia. By lowering LDL-C, simvastatin reduces the concentration of LDL particles, which contain apolipoprotein B (Apo B), thus lowering Apo B levels. Simvastatin can also modestly lower triglycerides (TG) and slightly increase high-density lipoprotein cholesterol (HDL-C). The effectiveness of Zocor in reducing cholesterol and improving cardiovascular health is significantly enhanced when combined with a healthy diet and lifestyle.

Mechanism of Action:
Simvastatin, a statin medication, is also an HMG-CoA reductase inhibitor, and it effectively lowers cholesterol by inhibiting the enzyme HMG-CoA reductase in the liver. This blockage reduces the liver's cholesterol production, prompting it to increase the number of LDL receptors on its surface. Consequently, more LDL cholesterol is removed from the bloodstream, significantly decreasing circulating LDL levels. While simvastatin can lower triglycerides and raise HDL, the effect is generally considered modest for triglycerides and small or slight for HDL. Furthermore, it may exert additional beneficial effects on blood vessels, independent of its lipid-modifying properties.

Take Zocor exactly as your doctor prescribes, following the instructions in the product monograph in Canada accompanying the medication. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Zocor, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Zocor (simvastatin). It is not an exhaustive list, and individual reactions can vary. This information is for educational purposes and should not replace professional medical advice. Before starting Zocor, it is crucial to discuss possible side effects and risks with your doctor or pharmacist.

Common side effects
- These are some common side effects of Zocor, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal pain;
• Bloating;
• Cold symptoms (stuffy nose, sneezing, sore throat);
• Constipation;
• Diarrhea;
• Eczema;
• Gas;
• Heartburn;
• Indigestion;
• Insomnia;
• Joint pain;
• Mild memory problems or confusion;
• Muscle pain or weakness;
• Nausea;
• Upper respiratory infection (like the common cold);
• Urinary tract infection (UTI)

Serious or rare side effects- Seek immediate medical attention or call emergency services if you experience any of the following:
• Atrial fibrillation - Fast or irregular heartbeat (some studies have suggested a possible small increased risk with statins, but this is still being investigated).
• Immune-Mediated Necrotizing Myopathy (IMNM) - Muscle weakness that may persist even after stopping the drug.
• Increased blood sugar - Statins, including simvastatin, have been associated with a small increased risk of developing type 2 diabetes in some individuals, especially those with pre-existing risk factors. Your doctor will monitor your blood sugar levels if necessary. Symptoms of diabetes may include increased thirst, frequent urination, and unexplained weight loss.
• Kidney problems - Changes in urination (little or no urination, painful urination), swelling in the ankles or feet, and shortness of breath.
• Liver problems - Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, pale stools, upper abdominal pain, loss of appetite, and unusual tiredness.
• Memory loss or confusion - These effects are reversible once the medication is stopped.
• Muscle problems (Myopathy and Rhabdomyolysis) - Unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever, unusual tiredness, or dark-colored urine. In rare cases, this can lead to kidney damage or failure.
• Serious allergic reactions - Symptoms can include difficulty breathing, swelling of the face, lips, tongue, or throat, hives, and severe skin rash.
• Severe skin reactions—such as Stevens-Johnson Syndrome, with symptoms like fever, sore throat, burning eyes, and a painful red or purple rash with blistering and peeling.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Zocor, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Zocor should not be used if:
• You have a known allergy to simvastatin or any ingredients in the medication. • You have active liver disease, including conditions like acute liver failure or decompensated cirrhosis. • You are taking certain strong CYP3A4 inhibitors that can significantly increase the risk of muscle problems (myopathy and rhabdomyolysis) or raise the levels of Zocor in your body, such as itraconazole, ketoconazole, posaconazole, voriconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors (like nelfinavir and ritonavir), cobicistat, and nefazodone and other strong CYP3A4 inhibitors. • You are taking other drugs that significantly increase the risk of myopathy, such as gemfibrozil, cyclosporine, and danazol.

Tell your doctor about all of your medical conditions, past and present, before starting Zocor. This is crucial because certain conditions can affect whether Zocor is right for you. These conditions may include, but are not limited to:
• A history of allergic reactions to other medications.
• Diabetes - While statins are often used in people with diabetes to manage cholesterol, it's still important for your doctor to know. • Kidney disease - Kidney function can impact how medications are processed in the body.
• Liver problems - Zocor can sometimes affect the liver, so pre-existing liver issues are a key consideration.
• Muscle problems or a history of muscle pain or weakness (especially if it was related to a statin medication): Zocor belongs to a class of drugs called statins, and muscle issues are a potential side effect.
• Thyroid problems - An underactive thyroid can sometimes affect cholesterol levels.

Drug Interactions:

Before taking Zocor, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the official Zocor prescribing information.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Zocor. Zocor may interact with other medicines but is not limited to:

• Drugs that may require a lower dose of simvastatin include, but are not limited to moderate CYP3A4 inhibitors such as calcium channel blockers like amlodipine, diltiazem, and verapamil, and certain heart rhythm medications like dronedarone. Amiodarone can also significantly increase simvastatin levels; lower doses or alternative statins may be necessary. Consult your doctor or pharmacist for guidance. Other medications in this category include ranolazine (chest pain medication).
• Other cholesterol-lowering drugs, such as other fibrates like fenofibrate and niacin (in high doses, especially in Chinese patients), can increase the risk of muscle problems when taken with simvastatin. Your doctor will carefully weigh the risks and benefits of such combinations.
• Other medications that may interact with simvastatin include colchicine (may increase the risk of muscle problems), digoxin (levels in the blood may increase, requiring monitoring), and warfarin (a blood thinner - simvastatin can increase its effects, potentially increasing bleeding risk, requiring closer monitoring). St. John's Wort, an herbal supplement for depression, can decrease simvastatin levels, reducing its effectiveness.
• Strong CYP3A4 inhibitors that should generally be avoided with simvastatin include, but are not limited to, certain antidepressants like nefazodone; certain azole antifungals like itraconazole, ketoconazole, posaconazole, and voriconazole; certain macrolide antibiotics like erythromycin and clarithromycin; cobicistat-containing products; the endometriosis drug danazol; gemfibrozil (a fibrate); certain hepatitis C antivirals like boceprevir and telaprevir; certain HIV protease inhibitors like ritonavir, nelfinavir, darunavir, and others; and the immunosuppressant cyclosporine.

Alcohol
Combining excessive alcohol consumption with Zocor (simvastatin) may increase the risk of liver problems. It is advisable to limit alcohol intake and discuss your alcohol consumption habits with your doctor if you are taking or considering taking Zocor to fully understand the potential risks.

Pregnancy and Breastfeeding:

Statins are generally contraindicated during pregnancy and are typically not recommended during breastfeeding due to potential risks to the fetus or infant. If you are pregnant, breastfeeding, or planning to become pregnant, it is crucial to consult your doctor immediately.

Frequently Asked Questions about Zocor at Canada Pharmacy Online:

Why is Zocor more affordable in Canada than in the United States?

Prescription drug prices, including Zocor, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Zocor 20 mg and 40 mg?

The difference in dosage represents the amount of active ingredient(s) present in the drug.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Zocor at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Zocor requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Zocor?

Yes, there is a generic alternative for this product called simvastatin.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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