Zosyn (Piperacillin/Tazobactam)

Name: Zosyn
Brand: Generic
SKU: 7600
Availability: InStock

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Qty-Price (USD)

There is no brand product of Zosyn.

Generic Equivalent of Zosyn

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Piperacillin/Tazobactam 10 x 30 ml Vials (CURRENTLY UNAVAILABLE)

Manufacturer: Generic

Country: Canada

Dosage: 2.25 gm

Qty-Price (USD):

Type:

Product: Piperacillin/Tazobactam 10 x 30 ml Vials (CURRENTLY UNAVAILABLE)

Manufacturer: Generic

Country: Canada

Dosage: 3.375 gm

Qty-Price (USD):

Type:

Product: Piperacillin/Tazobactam 10 x 30 ml Vials (CURRENTLY UNAVAILABLE)

Manufacturer: Generic

Country: Canada

Dosage: 4.5 gm

Qty-Price (USD):

Zosyn Information

Piperacillin/tazobactam at CanadaPharmacyOnline.com

The manufacturer of Zosyn (piperacillin/tazobactam) is Pfizer Canada ULC. Originally developed by Wyeth, it is a mainstay in hospital-based antibiotic therapy. In Canada, Zosyn remains a primary brand-name choice, while several manufacturers, including Sandoz, Apotex, and Teva, produce generic piperacillin/tazobactam for injection. The brand Zosyn is currently unavailable (at this pharmacy).

Generic piperacillin/tazobactam is sourced from manufacturers that meet applicable regulatory standards, ensuring the medication is bioequivalent to the brand-name version. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Piperacillin/tazobactam

Generic piperacillin/tazobactam contains the same active ingredients as brand-name Zosyn. It must meet the same effectiveness and quality standards. Studies have shown that the generic version is bioequivalent to brand-name Zosyn, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses can vary due to factors such as metabolism and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Piperacillin/tazobactam is available in the following form and strengths:
• Powder for solution: 2.25 g, 3.375 g, and 4.5 g single-dose vials.

The medication is administered intravenously by a healthcare professional. It is typically given as an infusion over 30 minutes, or in some cases, an extended infusion over 4 hours. Pediatric doses (for children 2 months and older) are calculated based on the child's weight and the specific type of infection.

Usage:

Zosyn is a potent, broad-spectrum injectable antibiotic used to treat serious bacterial infections throughout the body. It is primarily indicated for complicated intra-abdominal infections like appendicitis or peritonitis, as well as complicated skin and soft tissue infections, including those seen in diabetic patients. Additionally, it is used to treat postpartum infections, pelvic inflammatory disease, and severe lung infections, including community-acquired and hospital-acquired pneumonia. Zosyn is a combination therapy designed to fight bacteria that have developed resistance to other penicillins. Like all antibiotics, Zosyn is only effective against bacterial infections; it will not treat viral illnesses such as the common cold, flu, or COVID-19. It is essential to complete the full course of therapy as directed by a healthcare professional to ensure the bacteria are fully eliminated and to prevent the development of drug-resistant "superbugs."

Mechanism of Action
Zosyn works through a dual-action approach. The active ingredient, piperacillin, is a penicillin antibiotic that kills bacteria by inhibiting the synthesis of their cell walls, causing the cells to burst. The second ingredient, tazobactam, is a beta-lactamase inhibitor. While it does not kill bacteria directly, it acts as a shield by blocking the enzymes (beta-lactamases) that certain bacteria produce to defend themselves against antibiotics. This protection allows the piperacillin to remain effective against a wider range of resistant bacteria.

Zosyn is administered intravenously by healthcare staff, according to the product monograph. If you are receiving this medication, ensure you complete the full treatment course determined by your doctor to prevent the infection from returning or developing resistance.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Zosyn, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Zosyn (piperacillin/tazobactam). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Zosyn; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea or constipation
• Headache
• Nausea or vomiting
• Rash or itchy skin
• Trouble sleeping (insomnia)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Seizures or muscle twitching
• Severe watery or bloody diarrhea (which may indicate a C. difficile infection)
• Unusual bruising or bleeding
• Yellowing of the skin or eyes (jaundice)

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Zosyn, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Zosyn if:
• Allergies: You have a known hypersensitivity to piperacillin/tazobactam or to other ingredients in the drug.

Tell your doctor about all of your medical conditions, past and present, before starting Zosyn. This is crucial as certain conditions affect the drug's safety.
• A history of seizures
• Kidney disease: Dosage adjustments are necessary for patients with renal impairment to avoid toxic buildup.
• Low-sodium diet: Zosyn contains a significant amount of sodium; use caution if you are on a salt-restricted diet or have heart failure.

Drug Interactions

: Before taking Zosyn, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the prescribing information at https://labeling.pfizer.com/showlabeling.aspx?id=502.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Zosyn. Zosyn may interact with other medicines, including but not limited to:
• Aminoglycoside antibiotics (e.g., tobramycin, gentamicin): Zosyn can inactivate these antibiotics if mixed in the same IV line; they are often given separately.
• Blood thinners (e.g., heparin, warfarin): Zosyn may increase the risk of bleeding when taken with anticoagulants.
• Methotrexate: Zosyn can reduce the clearance of this cancer medication, potentially leading to toxic levels.
• Probenecid: This gout medication can slow the removal of Zosyn from your body, increasing its blood levels.
• Vancomycin: Using these two antibiotics together may increase the risk of kidney injury.
• Vecuronium: Zosyn may prolong vecuronium's muscle-relaxant effects during surgery.

Pregnancy and Breastfeeding:

There are no adequate and well-controlled studies of Zosyn in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Piperacillin is excreted in low concentrations in human milk; however, the effects on nursing infants have not been studied. Women who are breastfeeding should consult their doctor before receiving this medication.

Use in Children:

Zosyn is approved for use in children aged 2 months and older for specific infections, including complicated intra-abdominal infections. Dosage for children is calculated by a physician based on the child's weight and the severity of the infection. The safety and effectiveness of Zosyn in children younger than 2 months of age have not been established.

Frequently Asked Questions about Zosyn at Canada Pharmacy Online

Why is Zosyn more affordable in Canada than in the United States?

Prescription drug prices, including Zosyn, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Zosyn I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Zosyn per prescription from your doctor.

Can I buy Zosyn from you over the counter?

No, Zosyn requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Zosyn?

Yes, there is a generic alternative to Zosyn: piperacillin/tazobactam.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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