Heartgard Dog (Ivermectin)

Name: Heartgard Dog
Brand: Boehringer Ingelheim
SKU: 6173
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Heartgard Dog Plus (Pyrantel) Chewable 6 Cubes

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 68 ug(<11kg)

Qty-Price (USD):

Type:

Product: Heartgard Dog Plus (Pyrantel) Chewable 6 Tablets (ON BACKORDER)

Manufacturer: Merial

Country: India

Dosage: 68 ug(<11kg)

Qty-Price (USD):

Type:

Product: Heartgard Dog Plus (Pyrantel) Chewable 6 Cubes

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 136 ug (12-22kg)

Qty-Price (USD):

Type:

Product: Heartgard Dog Plus (Pyrantel) Chewable 6 Cubes

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 272 ug (23-45)kg

Qty-Price (USD):

Type:

Product: Heartgard Dog Plus (Pyrantel) Chewable 6 Tablets

Manufacturer: Merial

Country: India

Dosage: 272 ug (23-45)kg

Qty-Price (USD):

Generic Equivalent of Heartgard Dog

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Ivermectin Plus (Pyrantel) Chewable 6 Tablets

Manufacturer: Generic

Country: India

Dosage: 68 ug(<11kg)

Qty-Price (USD):

Type:

Product: Ivermectin Plus (Pyrantel) Chewable 6 Tablets

Manufacturer: Generic

Country: India

Dosage: 136 ug (12-22kg)

Qty-Price (USD):

Type:

Product: Ivermectin Plus (Pyrantel) Chewable 6 Tablets

Manufacturer: Generic

Country: India

Dosage: 272 ug (23-45)kg

Qty-Price (USD):

Heartgard Dog Information

medically reviewed by Carol Hou (BSc. Pharm) on December 10, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Heartgard Plus and Ivermectin at CanadaPharmacyOnline.com

The brand Heartgard was owned initially by Merial. Following a corporate acquisition, it is now globally owned and distributed by Boehringer Ingelheim Animal Health. In Canada, the official, Health Canada-approved product, which is most commonly known as Heartgard Plus, is distributed by Boehringer Ingelheim Animal Health Canada Inc.

Generic ivermectin/pyrantel is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturers of your dispensed medication may vary.

Important Information about Generic Ivermectin/Pyrantel

Generic ivermectin/pyrantel contains the same active ingredient as brand-name Heartgard Plus and must meet the same effectiveness and quality standards. This means it is designed to work in the same way as Heartgard Plus. Studies have shown that generic ivermectin/pyrantel is bioequivalent to brand-name Heartgard Plus, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts.

Dosage:

The Heartgard Plus brand-name product, which contains ivermectin and pyrantel, is available as a chewable tablet in the following strengths of ivermectin, categorized by dog weight:
• 68 ug (for dogs up to 11 kg / 25 lb)
• 136 ug (for dogs from 12 kg to 22 kg / 26 lb to 50 lb)
• 272 ug (for dogs from 23 kg to 45 kg / 51 lb to 100 lb)

Note: The strength is listed in micrograms (ug) of ivermectin. The pyrantel content (in milligrams, mg) is also part of the Heartgard Plus product, but it was not included in your original query.

Your veterinarian will determine the appropriate dose based on your dog's weight.

Usage:

Heartgard Plus (Ivermectin/Pyrantel) is a prescription medication used monthly to prevent heartworm disease by killing the infective third-stage heartworm larvae (L3) acquired in the previous month. It also treats and controls common intestinal infections caused by roundworms and hookworms. It is essential to have your dog tested for existing heartworm disease before starting Ivermectin therapy.

Mechanism of Action:
Heartgard Plus contains two different medications to protect your dog. Ivermectin prevents heartworm disease by targeting the nervous system of newly acquired heartworm larvae, causing paralysis and killing them before they can mature into dangerous adult worms in the heart and lungs. The second drug, pyrantel pamoate, works against intestinal parasites like roundworms and hookworms by causing spastic paralysis of their muscles. Because pyrantel acts directly in the dog's digestive tract, the paralyzed intestinal worms lose their ability to stick to the intestinal wall and are expelled from the body.

Take Heartgard Plus exactly as your veterinarian prescribes, following the instructions in the product information from Canada.ca. Consult a veterinarian for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Heartgard Dog, it is essential to discuss all possible side effects, risks, and interactions with your veterinarian.

Side Effects:

The information below outlines potential side effects of Heartgard Plus (Ivermectin/Pyrantel). It is not an exhaustive list, and individual reactions can vary.

Common side effects – These are common side effects of Heartgard Plus, but others are possible. Contact your veterinarian promptly if any side effects persist, worsen, or are concerning, or if your dog experiences any other concerning symptoms.
• Diarrhea
• Lethargy/Depression (unusual tiredness or low energy)
• Loss of Appetite (anorexia)
• Vomiting

Other Potential Side Effects (less common):
• Ataxia (incoordination, staggering, or unsteadiness when walking)
• Drooling (hypersalivation)
• Mydriasis (dilated pupils)

Serious Side Effects: Seek immediate veterinary attention or call emergency services if your dog experiences any of the following symptoms: • Allergic Reactions (signs may include hives, swelling of the face, or difficulty breathing)
• Convulsions or Seizures
• Hypersensitivity Reaction (signs may include transient diarrhea, weakness, or collapse).
o Note: This rare, severe reaction is linked to administering ivermectin to dogs with high circulating microfilariae (the offspring of adult heartworms). The rapid die-off of these microfilariae causes the response. This is why a negative heartworm test must be done before starting prevention.

Note on Herding Breeds (MDR1 Mutation)
Some herding breeds, such as Collies, Shetland Sheepdogs, and Australian Shepherds, have a genetic mutation (MDR1 gene) that makes them more sensitive to ivermectin at high doses. However, Heartgard Plus is safe at the low, preventative dose recommended for all dogs, including these sensitive breeds. Severe neurological symptoms usually occur only with very high doses or products meant for livestock.

Contraindications:

The following are key contraindications and important warnings (not an exhaustive list). Before your dog starts Heartgard Plus, you must discuss their complete medical history, including all current and past conditions and every medication they are taking, with your veterinarian.

Do NOT give Heartgard Plus (Ivermectin/Pyrantel) if your dog meets the following criteria:
• Dogs Less than 6 Weeks Old: Safety studies are based on dogs 6 weeks and older.
• Heartworm-Positive Dogs (Active Infection): Administering this medication to a dog with an existing infection and circulating microfilariae can cause severe, potentially life-threatening hypersensitivity reactions due to the rapid die-off of microfilariae. Your dog must test negative before starting prevention. (Note: Heartgard Plus may be used later in a formal treatment protocol under strict veterinary supervision.)
• Hypersensitivity: A known allergy or hypersensitivity to the active ingredients (ivermectin, pyrantel) or any component of the chewable formulation (such as beef).
• Sick or Debilitated Animals: Use in dogs that are sick, debilitated, or severely underweight.

Drug Interactions:

Consult your veterinarian to review all potential risks and drug interactions before administering Heartgard Plus. For complete and up-to-date information, refer to the official website of Boehringer Ingelheim Animal Health at https://bi-animalhealth.com/pets/canine/products/parasiticides/heartgard-plus.

Provide your veterinarian with a complete list of all your dog’s medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and any significant dietary changes, as these may interact with Heartgard Plus. Heartgard Plus may interact with other medicines, but is not limited to:

Interactions Affecting Ivermectin (Neurological Risk)
These drugs can potentially increase ivermectin levels in your dog's central nervous system (CNS), potentially increasing the risk of neurological side effects (like ataxia, tremors, or seizures), particularly in dogs with the MDR1 mutation.
• Azole Antifungals (e.g., Ketoconazole, Itraconazole): These can inhibit the metabolism of ivermectin.
• Antibiotics (e.g., Erythromycin, Clarithromycin): Certain macrolide antibiotics can increase drug concentrations.
• Blood Pressure Medications (e.g., Amlodipine, Diltiazem): Some calcium channel blockers can affect the P-gp pump.
• Immunosuppressants (e.g., Cyclosporine): This drug can increase the effects of ivermectin.
• Other Macrocyclic Lactones (e.g., Spinosad, Moxidectin): Although Heartgard Plus is often given with other preventatives, caution is sometimes advised when combining multiple macrocyclic lactones, which target the same nervous system receptors.

Interactions Affecting Pyrantel Pamoate (Antiparasitic Effect)
These interactions primarily involve pyrantel, the intestinal dewormer component, and may increase toxicity or decrease effectiveness.
• Organophosphates: These compounds, historically found in some flea and tick products (collars, dips, sprays), should not be used concurrently with pyrantel-containing products like Heartgard Plus, as the combination can increase toxicity.
• Other Intestinal Dewormers (e.g., Piperazine, Levamisole, Morantel): Co-administering pyrantel with other intestinal dewormers may increase the risk of side effects or lead to a dangerous overdose of deworming agents.

Frequently Asked Questions about Heartgard Plus at CanadaPharmacyOnline:

Why is Heartgard Plus more affordable in Canada than in the United States?

Prescription drug prices, including Heartgard Plus, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Heartgard Plus I am allowed to order at one time?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Heartgard Plus per your doctor's prescription.

Can I buy Heartgard Plus over the counter from you?

No, Heartgard Plus requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic version of Heartgard Plus for dogs?

Yes, generic alternatives containing the same active ingredients, Ivermectin and Pyrantel Pamoate, are available.

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Heartgard Dog Side Effects

Side Effects and Precautions

The common side effects of Heartgard Dog are weakness, vomiting, anorexia, transient diarrhea, mydriasis, staggering, convulsions, and hypersalivation.

Stop using Heartgard Dog and contact your doctor right away if you have any of the serious side effects such as:
• No stopping hypersalivation;
• Severe vomiting;
• Severe weakness;
• Worsening of your pets' condition

Warnings and Interactions

Heartgard Dog plus is also known as Pyrantel and comes as a chewable tablet mainly for dogs. Before you start using this medication for your dogs, you should consult your veterinarian. It is recommended that all dogs should be tested for existing heartworm infection before starting treatment with Heartgard Plus, which is not effective against adult D. Immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before starting a treatment regimen with Heartgard plus. You should not use Ivermectin if your dog is known to be allergic to it. Heartgard Plus should be given to dogs once per month. You should not use more than the prescribed dose by your veterinary doctor. Inform your Vet if there is no improvement in your pets despite regular use. If you suspect any strange behavior or sign of adverse reaction to the medication by your dogs, call your veterinary doctor immediately.

Before you start using Heartgard Dog for your dog, inform your vet doctor about your pet's medical history, especially if your dogs have:
• Dogs less than 6-week-old;
• Hypersensitivity or allergy to Ivermectin;
• kidney problems;
• Liver problems

Tell your doctor about all the medications you use for your dog, including prescriptions, over-the-counter medications, herbal products, and vitamin supplements. Tell your doctor if your dog is pregnant or just gave birth. There may be a drug interaction between Heartgard Dog and other drugs such as ketoconazole, itraconazole, cyclosporine, erythromycin, amlodipine besylate, and nifedipine.

Questions and Answers

Why is Heartgard Dog more affordable from Canada than the United States?

In general, all drug prices, not only Heartgard Dog, are more affordable to order from Canada because the price of both the brand and generic medication is regulated by the government. Also, since we established in 2006, our vision is to provide safe and affordable medication to people in the US.

Is it safe to buy Heartgard Dog from your pharmacy?

Our products are sourced only from facilities certified by authorities in the countries we import them from. CanadaPharmacyOnline.com has a rigorous process for selecting our partners so that you, our customer, get the safest medicine. We are also a Certified Canadian Pharmacy that adheres to the requirements imposed by the Province of British Columbia.

How much does Heartgard Dog tablets cost in Canada?

At our pharmacy, the cost of Heartgard Dog 272 ug (23-45kg) starts at $70.99 for 6 chewable tablets.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on getting you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering Heartgard Dog from us is very simple. You can place the order online or call Customer Service at 1866.920.3784. For additional information or for the ordering process, visit our How to Order page.

Are your Heartgard Dog prices competitive?

Yes, we are proud to offer some of the most competitive prices across Canadian pharmacies. In some cases, we might be able to either match or beat our competitors' prices. Please call our friendly customer service at 1866.920.3784.

Is there a limit on how many Heartgard Dog I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Heartgard Dog at one time, as per your doctor's prescription.

Can I buy Heartgard Dog over the counter from you?

No, Heartgard Dog requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Heartgard Dog?

Yes, there is a generic alternative available for this product called Ivermectin Plus (Pyrantel).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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