Symmetrel (Amantadine)

Name: Symmetrel
Brand: Generic
SKU: 0073
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no brand product of Symmetrel.

Generic Equivalent of Symmetrel

Type

Product

Manufacturer

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Qty-Price (USD)

Type:

Product: Amantadine Syrup

Manufacturer: Generic

Country: Canada

Dosage: 50 mg/5 ml /500 ml

Qty-Price (USD):

Type:

Product: Amantadine Capsule

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Amantadine Capsule

Manufacturer: Generic

Country: India

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Amantadine Tablet

Manufacturer: Generic

Country: India

Dosage: 100 mg

Qty-Price (USD):

Symmetrel Information

Amantadine at CanadaPharmacyOnline.com

The original manufacturer of the brand-name Symmetrel was Endo Pharmaceuticals (formerly DuPont Pharma). Symmetrel is a multifaceted medication that acts as both an antiviral and a treatment for neurological disorders. In many markets, including Canada and the U.S., brand-name Symmetrel has been discontinued or placed in a dormant status. The brand Symmetrel is currently unavailable (at this pharmacy).

The generic amantadine remains widely available and is produced by several reputable manufacturers that meet the strict standards of Health Canada and the FDA. Common generic producers include Apotex, Teva, and Sandoz. Generic amantadine is sourced from manufacturers that meet applicable regulatory standards.

Important Information about Generic Amantadine

Generic amantadine contains the same active ingredient as brand-name Symmetrel. It must meet the same effectiveness and quality standards. This means it is designed to work like Symmetrel. Studies have shown that generic amantadine is bioequivalent to brand-name Symmetrel, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Amantadine is available in several oral forms and strengths:
• Capsules: 100 mg (usually red, soft-gelatin).
• Tablets: 100 mg.
• Syrup: 50 mg/5 mL (often used for pediatric patients or those with swallowing difficulties).

The dosage depends on the severity of the condition and the form used.

Usage:

Symmetrel is used to treat the symptoms of Parkinson's disease and extrapyramidal reactions (uncontrolled muscle movements) caused by certain drugs. It helps improve muscle control and reduce stiffness, shakiness, and shuffling. Additionally, while it was once a primary flu treatment, the CDC and Health Canada recommend against it due to viral resistance. It is also sometimes used off-label to treat fatigue associated with multiple sclerosis.

Mechanism of Action
Amantadine, the active ingredient in Symmetrel, works through two primary pathways depending on what it is treating. It helps increase dopamine levels in the brain. It does this by stimulating the release of dopamine from nerve endings and blocking its reabsorption. This helps smooth out body movements and reduce tremors. It also acts as an antiviral by blocking the virus's ability to uncoat itself. When the Influenza A virus enters a cell, it needs to release its genetic material to take over. Symmetrel blocks a specific viral protein (M2) that enables this, effectively preventing the virus from spreading.

Take Symmetrel exactly as your doctor prescribes, according to the product monograph. You can take it with or without food. If you are taking it to prevent the flu, start as soon as possible after exposure. If you are taking it for Parkinson's, do not stop the medication abruptly, as this can cause a severe worsening of symptoms.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Symmetrel, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Symmetrel (amantadine). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Symmetrel; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Constipation
• Dizziness or lightheadedness
• Dry mouth
• Insomnia (trouble sleeping)
• Livedo Reticularis: A harmless, purplish, lace-like pattern on the skin (usually on the legs).
• Loss of appetite
• Nausea

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Difficulty urinating: Feeling like you cannot empty your bladder.
• Hallucinations or confusion: Especially in elderly patients.
• Impulse control disorders: You may experience intense urges to gamble, spend money, binge eat, or experience increased sexual urges.
• Neuroleptic Malignant Syndrome: High fever, muscle stiffness, and rapid heartbeat (especially if the dose is reduced too quickly).
• Suicidal thoughts
• Unexplained swelling in the hands, ankles, or feet.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Symmetrel, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Symmetrel/amantadine if:
• Allergies: You have a known hypersensitivity to amantadine
• Glaucoma: Specifically, untreated narrow-angle glaucoma.
• Seizures: It may increase the risk of seizures in some patients.

Tell your doctor about all of your medical conditions, past and present, before starting Symmetrel. This is crucial as certain conditions affect the drug's safety.
• Kidney Disease: The dose must be carefully adjusted, as the kidneys clear this drug.

Drug Interactions:

Before taking Symmetrel, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the package leaflet at http://novartis.com/sg-en/sites/novartis_sg/files/symmetrel-apr%202019.sin-approved28Jun19.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Symmetrel. Symmetrel may interact with other medicines, including but not limited to:
• Anticholinergic drugs: Taking Symmetrel with drugs like Benadryl or certain bladder meds can increase side effects like dry mouth and confusion.
• Live flu vaccine: Symmetrel may interfere with the effectiveness of the inhaled (live) flu vaccine. Wait at least 48 hours after stopping the drug before getting the vaccine.
• Thiazide diuretics: Can increase amantadine levels in your blood.

Pregnancy and Breastfeeding:

Symmetrel is not recommended during pregnancy unless the benefits clearly outweigh the risks, as animal studies have shown potential for heart defects and other issues. Amantadine passes into breast milk and can potentially harm a nursing infant. It may also decrease milk production. Breastfeeding is generally not recommended.

Use in Children:

Symmetrel is approved for the treatment of Influenza A in children 1 year of age and older. The safety and effectiveness for Parkinson's symptoms in children have not been established.

Frequently Asked Questions about Symmetrel at Canada Pharmacy Online

Why is Symmetrel more affordable in Canada than in the United States?

Prescription drug prices, including Symmetrel, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Symmetrel I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Symmetrel per prescription from your doctor.

Can I buy Symmetrel from you over the counter?

No, Symmetrel requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Symmetrel?

Yes, the generic amantadine is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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