Amilzide (Amiloride/Hydrochlorothiazide)

Name: Amilzide
Brand: Generic
SKU: 7603
Availability: InStock

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There is no brand product of Amilzide.

Generic Equivalent of Amilzide

Type

Product

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Type:

Product: Amiloride/Hydrochlorothiazide (Dispensing Note)

Manufacturer: Generic

Country: Canada

Dosage: 5 mg/50 mg

Qty-Price (USD):

Amilzide Information

Amiloride/Hydrochlorothiazide at CanadaPharmacyOnline.com

The brand-name Amilzide is not currently available at this pharmacy. Amilzide (amiloride hydrochloride/hydrochlorothiazide) is also known internationally as Moduretic.

The generic amiloride/hydrochlorothiazide 5 mg/50 mg tablets are available at this pharmacy, manufactured in Canada by various manufacturers that meet Health Canada's quality and safety standards. The specific manufacturer of your dispensed medication may vary based on pharmacy inventory.

Important Information about Generic Amiloride/Hydrochlorothiazide

Generic amiloride/hydrochlorothiazide contains the same active ingredients as brand-name Amilzide. It must meet the same effectiveness and quality standards. This means it is designed to work like Amilzide. Studies have shown that generic amiloride/hydrochlorothiazide is bioequivalent to brand-name Amilzide, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Amilzide (amiloride/hydrochlorothiazide) is available in the following strengths:
• Tablets: 5 mg/50 mg oral tablets

The usual dose is one tablet once daily with food. In some cases, your doctor may prescribe up to a maximum of four tablets per day for severe fluid retention, though hypertension treatment typically does not exceed two tablets daily. Dosage should be adjusted according to your doctor's instructions. It is recommended to take Amilzide at the same time each day to help maintain a steady fluid balance and to take it in the morning to prevent waking up at night to urinate.

Usage:

Amilzide is a combination of two diuretics (water pills) indicated for hypertension, congestive heart failure, and hepatic cirrhosis with ascites and edema in patients who develop low potassium (hypokalemia) when taking thiazide diuretics alone, or in whom maintaining a normal blood potassium level is clinically important. For example, patients taking digoxin (a heart medication) or those with significant heart rhythm problems. Amilzide may be used alone or in combination with other blood pressure medications, such as beta-blockers or methyldopa.

The two active ingredients work together to promote effective diuresis (increased urine output) while helping maintain a more balanced potassium level. Amiloride is added specifically to counteract the potassium loss caused by hydrochlorothiazide, reducing the risk of low potassium (hypokalemia) that can occur when hydrochlorothiazide is used alone. Take Amilzide daily as directed by your doctor, even when you feel well.

Mechanism of Action
Amilzide combines two types of water pills that lower blood pressure and reduce fluid build-up through different mechanisms. Hydrochlorothiazide is a thiazide diuretic that acts in the kidneys to increase salt and water excretion in the urine, thereby reducing blood volume and lowering blood pressure. However, hydrochlorothiazide also causes the kidneys to lose potassium, which can lead to low potassium levels (hypokalemia). Amiloride is a potassium-sparing diuretic that works in a different part of the kidney, helping to excrete sodium and water while retaining potassium. By combining the two, Amilzide produces effective fluid removal and blood pressure lowering while reducing the risk of the potassium loss that would occur with hydrochlorothiazide alone.

Take Amilzide exactly as your doctor prescribes, according to the instructions in the product monograph. Take it with food to reduce the risk of stomach upset.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Amilzide, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Amilzide (amiloride/hydrochlorothiazide). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Amilzide; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea, nausea, or an upset stomach.
• Dizziness or headache
• Fatigue or weakness
• Increased urination
• Muscle cramps

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• High Potassium (Hyperkalemia): Muscle weakness, a slow or irregular heartbeat, numbness or tingling, or difficulty breathing. This is the most important serious risk of Amilzide, particularly in patients with kidney problems, diabetes, the elderly, or those taking other potassium-raising drugs. If hyperkalemia develops, Amilzide must be stopped immediately.
• Low Blood Pressure (Hypotension): Severe dizziness or fainting, particularly when standing up quickly.
• Low Sodium (Hyponatremia): Headache, confusion, weakness, lethargy, or seizures. Thiazide diuretics can cause low sodium levels.
• Severe Allergic Reaction: Hives, rash, or swelling of the face, lips, tongue, or throat.
• Worsening Kidney Function: Decreased urine output, significant swelling, or a sudden change in how much you are urinating. Seek medical attention promptly.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Amilzide, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Amilzide/amiloride/hydrochlorothiazide if:
• Allergies: You have a known hypersensitivity to amiloride, hydrochlorothiazide, other sulfonamide-derived drugs, or any ingredient in the tablet.
• Anuria: You are unable to produce urine.
• High Potassium (Hyperkalemia): You already have elevated serum potassium levels (above 5.5 mEq/L).
• Severe Kidney Disease: Creatinine clearance below 30 mL/min; thiazide diuretics are ineffective, and amiloride can cause dangerous potassium build-up.

Tell your doctor about all of your medical conditions, past and present, before starting Amilzide. This is crucial as certain conditions affect the drug's safety.
• Diabetes — amiloride should be discontinued at least 3 days before a glucose tolerance test; insulin requirements may change; blood glucose should be monitored closely, and kidney function must be evaluated frequently.
• Gout or high uric acid levels — hydrochlorothiazide can raise uric acid and precipitate gout
• Heart disease, including heart failure — monitor electrolytes carefully, particularly potassium
• Kidney impairment — increased risk of potassium accumulation; Amilzide is not recommended in severe renal impairment
• Liver disease (cirrhosis) — use with extra caution; electrolyte changes may precipitate hepatic coma.
• If you are on a low-salt diet
• Systemic Lupus Erythematosus (SLE) — Thiazides can cause an activation or exacerbation of lupus.

Drug Interactions:

Before taking Amilzide, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00019282.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Amilzide. Amilzide may interact with other medicines, including but not limited to:
• ACE inhibitors and angiotensin receptor blockers (ARBs): These drugs raise potassium levels. Combining them with amiloride significantly increases the risk of dangerous hyperkalemia. This combination should generally be avoided or used only with very close monitoring of potassium.
• Antidiabetic agents (insulin and oral hypoglycemics): Hydrochlorothiazide may impair blood sugar control and increase blood glucose levels. Antidiabetic drug requirements may need to be adjusted.
• Digoxin: Potassium levels affect how safely digoxin works in the heart. Amilzide helps maintain potassium balance, which is one reason it is particularly useful in patients on digoxin. Monitor potassium and digoxin levels closely.
• Lithium: Hydrochlorothiazide reduces renal clearance of lithium, potentially raising lithium levels to toxic concentrations. Concurrent use is generally not recommended.
• NSAIDs (e.g., ibuprofen, naproxen): May reduce the blood pressure-lowering and diuretic effects of Amilzide and can worsen kidney function.
• Other potassium-raising drugs (e.g., potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium): Must not be combined with amiloride due to the risk of dangerous hyperkalemia.

Pregnancy and Breastfeeding:

Amilzide is not recommended during pregnancy. Hydrochlorothiazide crosses the placental barrier and has been associated with fetal and neonatal jaundice and thrombocytopenia. The use of diuretics in otherwise healthy pregnant women is not routinely recommended. Consult your doctor before using Amilzide if you are pregnant or planning to become pregnant.

Amiloride passes into animal milk, and hydrochlorothiazide passes into human breast milk. Due to the potential for serious adverse effects in nursing infants, breastfeeding is not recommended while taking Amilzide. Discuss the risks and benefits with your doctor.

Use in Children:

The safety and efficacy of Amilzide in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Amilzide at Canada Pharmacy Online

Why is Amilzide more affordable in Canada than in the United States?

Prescription drug prices, including Amilzide, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Amilzide I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Amilzide per your doctor's prescription.

Can I buy Amilzide from you over the counter?<

No, Amilzide requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Amilzide?

Yes, the generic alternative is available.

Blog Post:

Hypertension: Don't Let the Silent Killer Lurk in Your Body

Latest News:

Amiloride is noninferior to spironolactone for reducing blood pressure in patients with resistant hypertension, offering a well-tolerated alternative without hormonal side effects – JAMA (published May 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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