Burinex (Bumetanide)

Name: Burinex
Brand: Knight Therapeutics Inc
SKU: 5469
Availability: InStock

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Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Burinex

Manufacturer: Knight Therapeutics Inc

Country: Canada

Dosage: 1mg

Qty-Price (USD):

Type:

Product: Burinex

Manufacturer: Knight Therapeutics Inc

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Generic Equivalent of Burinex

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Product

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There is no generic product of Burinex.

Burinex Information

medically reviewed by Carol Hou (BSc. Pharm) on July 2, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Burinex at CanadaPharmacyOnline.com

The brand Burinex (containing the active ingredient bumetanide) is primarily used in Canada and is marketed by Knight Therapeutics Inc.; the same medication is available in the United States under the brand name Bumex.

Generic bumetanide is currently unavailable (at this pharmacy).

Dosage:

Burinex is commonly available in 1 mg and 5 mg oral tablets.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Burinex (bumetanide) is a prescription medication used to treat edema, which is the medical term for fluid retention and swelling in the body. This excess fluid buildup can occur due to various underlying medical conditions, such as congestive heart failure, kidney disease, and liver disease. Burinex works by acting on the kidneys to increase the production and excretion of urine, thereby helping the body eliminate excess water and salt. This, in turn, reduces swelling and alleviates associated symptoms like shortness of breath.

Mechanism of Action:
Burinex (bumetanide) is a potent loop diuretic, also known as a "water pill," that acts on the kidneys by inhibiting the sodium-potassium-chloride (Na-K-2Cl) cotransporter in the thick ascending limb of the loop of Henle. This inhibition prevents the reabsorption of sodium, potassium, and chloride, leading to increased excretion of these electrolytes and, consequently, water, ultimately resulting in increased urine output and reduced fluid overload and edema.

Take Burinex exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Burinex, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Burinex (bumetanide). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Burinex, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Dizziness
• Dry mouth
• Headache
• Increased thirst
• Increased urination
• Low blood pressure
• Muscle cramps
• Nausea

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Confusion, hallucinations, or changes in mental status.
• Dehydration: Symptoms include extreme thirst, decreased urination, dizziness, confusion, and a fast heartbeat.
• Electrolyte imbalances: Low levels of potassium (hypokalemia) (symptoms can include muscle weakness, fatigue, constipation, twitching, confusion, irregular heartbeat, seizures), sodium (hyponatremia) (symptoms can include nausea, vomiting, headache, confusion, seizures), magnesium (hypomagnesemia), calcium (hypocalcemia), and chloride (hypochloremia). Symptoms can include muscle weakness, twitching, confusion, irregular heartbeat, and seizures.
• Hearing problems: Ringing in the ears (tinnitus) or hearing loss.
• Heart problems: Fast or irregular heartbeat.
• Kidney problems: A Change in the amount of urine.
• Low platelet count (thrombocytopenia): Unusual bruising or bleeding, pinpoint red skin spots.
• Severe allergic reactions: Rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing.
• Severe skin reactions: Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) with symptoms like rash, fever, blistering, peeling skin.
• Unexplained bruising or bleeding, fever, sore throat, and mouth ulcers (possible signs of a blood disorder).

Long-Term Side Effects:
Bumetanide can be used for long-term edema management, but regular blood and urine tests are required to monitor electrolyte balance and kidney function. Potential long-term concerns include the ongoing risk of electrolyte imbalances, dehydration, and impact on kidney function, particularly in vulnerable populations.

Side Effects in the Elderly:
Elderly patients on Burinex must be closely monitored by their healthcare provider. Older adults may be more susceptible to specific side effects due to age-related changes in kidney, liver, and heart function. They have a higher risk of:
• Dehydration: Due to reduced thirst sensation and kidney function.
• Dizziness and falls: Due to low blood pressure or electrolyte imbalances.
• Electrolyte imbalances: Age-related organ function decline can exacerbate these issues.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Burinex, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Burinex should not be used if you:
• Anuria: This is a condition in which the kidneys are not producing urine. Burinex is a diuretic that works by increasing urine production, so it is not effective and could be harmful if you are not producing urine.
• Have had a definite allergic reaction to bumetanide. A history of allergy to other sulfonamide antibiotics should be discussed with your doctor, as cross-reactivity is possible but not absolute.
• Have hepatic coma: This is a serious complication of liver disease. Burinex can worsen electrolyte imbalances, which can precipitate or exacerbate hepatic encephalopathy and coma.
• Have significantly low essential electrolytes like potassium, sodium, or chloride levels. Using Burinex can further deplete these levels, leading to dangerous complications. This condition should be corrected before starting Burinex.

Tell your doctor about all of your medical conditions, past and present, before starting Burinex. This is crucial because certain conditions affect whether Burinex is right for you. These conditions may include, but are not limited to:
• Dehydration: Burinex promotes fluid loss, which can worsen dehydration. Ensure you are adequately hydrated before and during treatment.
• Diabetes: Burinex can affect blood sugar levels, so careful monitoring is needed in diabetic patients, and their antidiabetic medication may need adjustment.
• Gout or high uric acid levels (hyperuricemia): Burinex can increase uric acid levels, potentially triggering gout attacks.
• History of hearing problems: Burinex can, in rare cases, cause hearing impairment or tinnitus.
• Kidney disease: While Burinex can be used to induce diuresis in renal insufficiency, if you experience a marked increase in blood urea nitrogen (BUN) or creatinine, or develop oliguria (low urine output) during Burinex therapy, it may be a sign to discontinue the medication.
• Liver disease: While not an absolute contraindication (unless hepatic coma is present), Burinex should be used cautiously in patients with liver disease due to the risk of electrolyte imbalances and hepatic encephalopathy.
• Low blood pressure (hypotension): Burinex can further lower blood pressure, so it should be used cautiously if you already have it.
• Low blood volume (hypovolemia): Burinex can worsen this condition due to its diuretic effect.
• Low calcium or magnesium levels (hypocalcemia, hypomagnesemia): Burinex can further lower these electrolyte levels.
• Thrombocytopenia (low platelets): Burinex has been rarely associated with thrombocytopenia, so caution is advised.

Drug Interactions:

Before taking Burinex, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to Bumetanide: MedlinePlus Drug Information: https://medlineplus.gov/druginfo/meds/a684051.html.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Burinex. Burinex may interact with other medicines, but is not limited to:

Drugs that can increase the risk of electrolyte imbalances:
• Corticosteroids (e.g., prednisone, hydrocortisone): These can increase sodium retention and potassium loss, counteracting the effects of bumetanide on sodium excretion and increasing the risk of hypokalemia.
• Laxatives: Chronic use of stimulant laxatives can lead to potassium loss, increasing the risk of hypokalemia when taken with bumetanide.
• Other Diuretics (water pills): Concurrent use can lead to excessive fluid and electrolyte loss, increasing the risk of dehydration, low potassium (hypokalemia), low sodium (hyponatremia), and other electrolyte disturbances.

Drugs that can increase the risk of ototoxicity (hearing damage):
• Aminoglycoside Antibiotics (e.g., gentamicin, tobramycin, amikacin): Using bumetanide with these antibiotics, especially in patients with kidney problems or when administered intravenously, may increase the risk of hearing loss and tinnitus.
• Other Ototoxic Drugs: Other medications known to affect hearing, such as cisplatin, should be used cautiously with bumetanide.

Drugs affected by changes in electrolyte levels caused by bumetanide:
• Antiarrhythmic Drugs (e.g., amiodarone, sotalol, disopyramide, flecainide): Electrolyte imbalances caused by bumetanide can affect the heart's electrical activity and increase the risk of irregular heartbeats when used with these drugs.
• Digoxin: Low potassium levels (hypokalemia) caused by bumetanide can increase the risk of digoxin toxicity, potentially leading to serious heart rhythm problems.
• Lithium: Bumetanide can reduce the kidneys' ability to eliminate lithium, leading to increased lithium levels in the blood and an increased risk of lithium toxicity. This combination should generally be avoided.

Drugs whose effects may be altered by bumetanide:
• Antidiabetic Medications (oral hypoglycemic agents, insulin): Bumetanide can affect blood glucose levels, potentially leading to hyperglycemia (high blood sugar). Dosage adjustments of antidiabetic medications may be required.
• Antihypertensive Medications (drugs for high blood pressure): Bumetanide can lower blood pressure, and when taken with other antihypertensive drugs, it can lead to an excessive drop in blood pressure (hypotension). Dosage adjustments of the antihypertensive medication may be necessary. • Desmopressin: Bumetanide may decrease the effectiveness of desmopressin.
• Nonsteroidal Anti-inflammatory Drugs (NSAIDs) (e.g., ibuprofen, naproxen, indomethacin): NSAIDs can reduce bumetanide's diuretic and blood pressure-lowering effects by interfering with prostaglandin synthesis in the kidneys. Concurrent use of bumetanide with NSAIDs should be approached with caution, and your doctor may need to adjust your dosage or monitor you more closely.
• Probenecid: This medication, used for gout, can reduce the effectiveness of bumetanide by inhibiting its secretion in the kidneys. Concurrent use is generally not recommended.

Other potential interactions:
• Certain Painkillers (containing high amounts of sodium): Some soluble painkillers contain significant amounts of sodium, which can counteract the sodium-excreting effect of bumetanide.
• Herbal Remedies and Supplements: Some supplements, like ginseng and ephedra, may interact with bumetanide, potentially affecting blood pressure or fluid balance. It's important to discuss all supplements with your doctor.

Alcohol
Alcohol consumption may increase the risk of dehydration and low blood pressure, potentially enhancing some side effects of bumetanide, such as dizziness.

Pregnancy and Breastfeeding:
The safety of Burinex during pregnancy has not been fully established. It should be used during pregnancy only if the potential benefits outweigh the risks to the fetus. It is also unknown if bumetanide passes into breast milk, so caution should be exercised when used in breastfeeding women.

Use in Children:
The safety and effectiveness of bumetanide in neonates, infants, children, and adolescents under 18 years of age have not been established.

Frequently Asked Questions about Burinex at Canada Pharmacy Online:

Why is Burinex more affordable in Canada than in the United States?

Prescription drug prices, including Burinex, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Burinex 1 mg and 5 mg?

The dosage difference represents the amounts of the same active ingredient (bumetanide) in each tablet.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Burinex at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Burinex requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Burinex?

Yes, there is a generic alternative for this product called bumetanide.

What is the best time to take bumetanide?

It's generally best to take bumetanide in the morning or early afternoon to avoid frequent urination during the night. If you take multiple doses, try to take the last dose 4-6 hours before bedtime.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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