Clinoril (Sulindac)

Name: Clinoril
Brand: Generic
SKU: 7092
Availability: InStock

Type

Product

Manufacturer

Country

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Qty-Price (USD)

There is no brand product of Clinoril.

Generic Equivalent of Clinoril

Type

Product

Manufacturer

Country

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Qty-Price (USD)

Type:

Product: Sulindac Tablet

Manufacturer: Generic

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Type:

Product: Sulindac Tablet

Manufacturer: Generic

Country: Canada

Dosage: 200 mg

Qty-Price (USD):

Clinoril Information

medically reviewed by Carol Hou (BSc. Pharm) on September 4, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Sulindac at CanadaPharmacyOnline.com

The brand Clinoril is currently unavailable (at this pharmacy).

Generic sulindac is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Clinoril:

Generic sulindac contains the same active ingredient as the brand-name Clinoril and is required to meet the same safety, effectiveness, and quality standards as the brand-name product. This means it's designed to work in the same way as sulindac. Studies have demonstrated bioequivalence between generic and brand-name sulindac, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic sulindac, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage

The generic form of sulindac is available as oral tablets in two common strengths:
• 150 mg
• 200 mg

Your doctor will determine the appropriate dose and duration of use based on your individual needs and medical history.

Usage

Clinoril (sulindac) is a prescription medication used to relieve mild to moderately severe pain, inflammation, and stiffness associated with various conditions, including:
• Acute gouty arthritis
• Acute painful shoulder (bursitis or tendinitis)
• Ankylosing spondylitis
• Osteoarthritis
• Rheumatoid arthritis

Mechanism of Action
Sulindac is a prodrug, meaning it is inactive until metabolized in the body. After being absorbed, it is converted by the liver into an active sulphide metabolite which inhibits cyclooxygenase (COX) enzymes (COX-1 and COX-2). It also forms an inactive sulfone metabolite. By inhibiting the synthesis of prostaglandins—compounds that play a key role in the body's inflammatory response—the active form of sulindac reduces inflammation, pain, and fever.

Take Clinoril exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Clinoril, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Clinoril, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Clinoril; other side effects may also occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Constipation, diarrhea, gas
• Dizziness, headache
• Stomach irritation or upset: heartburn, nausea, vomiting
• Rash or itching

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Severe rash, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing. This is a life-threatening emergency.
• Blood disorders: Symptoms of anemia, such as unusual tiredness, pale skin, or shortness of breath.
• Cardiovascular events: NSAIDs like sulindac carry a Boxed Warning about the increased risk of serious and fatal cardiovascular thrombotic events, such as heart attack or stroke. This risk can increase with the duration of use.
• Gastrointestinal bleeding: Symptoms include severe stomach pain, black or tarry stools, or vomiting that looks like coffee grounds.
• Kidney problems: Symptoms include a decrease in urination, swelling of the feet or ankles, or shortness of breath.
• Liver problems: Symptoms include nausea, unusual tiredness, itching, dark urine, or yellowing of the skin or eyes (jaundice).

Contraindications

The following is not an exhaustive list of contraindications. Before starting Clinoril, it is essential to discuss all your medical conditions, past and present, as well as all medications you are currently taking, with your doctor or pharmacist.

Clinoril should not be used if:
• You are allergic to sulindac, other NSAIDs, or any other ingredient in the medication.
• You are in the perioperative setting of coronary artery bypass graft (CABG) surgery.
• You are in the third trimester of pregnancy.
• You have an active gastric ulcer, gastrointestinal bleeding, or inflammatory bowel disease.
• You have a history of asthma, hives, or other allergic-type reactions after taking aspirin or other NSAIDs.
• You have severe uncontrolled heart failure, severe liver impairment, or severe renal impairment.

Tell your doctor about all of your medical conditions, past and present, before starting Clinoril. This is crucial because certain conditions affect whether Clinoril is right for you. These conditions may include, but are not limited to:
• A history of bleeding disorders
• A history of heart disease, high blood pressure, or stroke
• A history of stomach ulcers or bleeding
• Diabetes
• Fluid retention or swelling (edema)
• Liver or kidney disease

Drug Interactions

Before taking Clinoril, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the Details for Clinoril | Drug and Health Products Portal at https://dhpp.hpfb-dgpsa.ca/dhpp/resource/3367.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Clinoril may interact with other medicines, but is not limited to:
• Blood pressure medications: Can reduce the blood pressure-lowering effects of certain medicines.
• Blood thinners (e.g., warfarin): Increased risk of serious bleeding.
• Cyclosporine: Increased risk of kidney toxicity.
• Diuretics ("water pills"): Reduced effectiveness of diuretics and an increased risk of kidney problems.
• Lithium: Can increase the concentration of lithium in the blood, leading to toxicity.
• Methotrexate: The combination can increase the risk of methotrexate toxicity.
• Oral hypoglycemic agents: Can increase the risk of hypoglycemia (low blood sugar).
• Other NSAIDs: Avoid taking other NSAIDs to reduce the risk of side effects.

Pregnancy and Breastfeeding

Third Trimester: Do not use sulindac during the third trimester of pregnancy. Using this medication at this stage can cause premature closure of a fetal blood vessel called the ductus arteriosus, which can be harmful to the baby.

First & Second Trimesters: For the first and second trimesters, sulindac should only be used if your doctor determines that the potential benefits clearly outweigh the risks to the fetus.

Breastfeeding: Sulindac is known to pass into breast milk. Since there is a potential for harm to a breastfed baby, you should discuss this with your doctor. Together, you and your doctor can decide whether to stop breastfeeding or stop using the medication, based on your health needs and the potential risks to the infant.

Use in the Elderly

Elderly patients may be at a higher risk of serious side effects, particularly gastrointestinal bleeding and kidney problems. Close monitoring is recommended. The lowest effective dose should be used for the shortest possible duration.

Use in Children

Sulindac is not recommended for children and adolescents under 18 years of age, as its safety and effectiveness in this population have not been confirmed. It should only be used in a child under the direct supervision and prescription of a qualified doctor, who will determine the appropriate use and dosage.

Frequently Asked Questions about Clinoril at Canada Pharmacy Online:

Why is Clinoril more affordable in Canada than in the United States?

Prescription drug prices, including Clinoril, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Clinoril at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Clinoril requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

How should I take Clinoril?

Take Clinoril with food or milk to reduce stomach irritation. It is best to take it at the same time each day to maintain consistent medication levels.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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