Cordarone (Amiodarone)

Name: Cordarone
Brand: Generic
SKU: 0263
Availability: InStock

Type

Product

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Qty-Price (USD)

There is no brand product of Cordarone.

Generic Equivalent of Cordarone

Type

Product

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Qty-Price (USD)

Type:

Product: Amiodarone

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Amiodarone

Manufacturer: Generic

Country: United Kingdom

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Amiodarone

Manufacturer: Generic

Country: Canada

Dosage: 200 mg

Qty-Price (USD):

Type:

Product: Amiodarone

Manufacturer: Generic

Country: United Kingdom

Dosage: 200 mg

Qty-Price (USD):

Cordarone Information

medically reviewed by Carol Hou (BSc. Pharm) on July 1, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Amiodarone at CanadaPharmacyOnline.com

Brand Cordarone is currently unavailable (at this pharmacy).

Generic amiodarone is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Amiodarone:

Generic amiodarone contains the same active ingredient as brand-name Cordarone and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Cordarone. Studies have shown that generic amiodarone is bioequivalent to brand-name Cordarone, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

Generic amiodarone is available in 100 mg and 200 mg oral tablets (at our pharmacy).

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Amiodarone (the active ingredient in Cordarone) is indicated for treating various heart rhythm disorders. It is particularly effective for the treatment of life-threatening ventricular arrhythmias such as ventricular fibrillation and sustained ventricular tachycardia. Amiodarone is also widely used for certain supraventricular arrhythmias like atrial fibrillation, both for rhythm control (to maintain a normal heart rhythm) and rate control (to slow the heart rate), especially in patients for whom other therapies are unsuitable or have been ineffective, or when other treatments are not preferred.

Mechanism of Action
Amiodarone is a powerful antiarrhythmic drug that stabilizes the heart's rhythm in several ways. It's a Class III antiarrhythmic that blocks potassium channels, prolonging the heart's electrical recovery time and preventing abnormal beats. But it doesn't stop there; amiodarone also has properties of other antiarrhythmic classes: it blocks sodium channels to slow electrical conduction, acts like a beta-blocker to reduce heart rate and stress, and even has mild calcium channel-blocking effects. This multi-faceted action makes it highly effective for many heart rhythm disorders.

Take generic amiodarone exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Cordarone, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with amiodarone. It is not an exhaustive list, and individual reactions can vary.

These are some common side effects of amiodarone, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Changes in taste and smell
• Changes in saliva amount
• Constipation
• Decreased sex drive
• Difficulty sleeping
• Dizziness or lightheadedness
• Fatigue
• Flushing
• Headache
• Lack of coordination
• Loss of appetite
• Nausea and vomiting
• Tremor or shaking

Less Common Side Effects:
• Abdominal pain
• Bad taste in the mouth
• Changes in the menstrual cycle
• Decreased concentration
• Dry eyes
• Excessive sweating
• Muscle weakness
• Nervousness
• Pain and swelling in the scrotum
• Poor coordination
• Restlessness
• Sensitivity of eyes to light
• Swelling in the extremities
• Thinning hair
• Uncontrollable shaking
• Weight changes

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic Reactions: Hives, difficulty breathing, face/lips/tongue/throat swelling.
• Liver Problems: Nausea, vomiting, dark urine, excessive tiredness, yellowing of skin/eyes (jaundice), itching, upper right stomach pain, pale stools.
• Lung Problems: Shortness of breath, wheezing, cough (dry or with blood), fever, chest pain.
• Nerve Problems (Peripheral Neuropathy): Numbness/tingling in hands/legs/feet, weakness, uncoordinated movements, trouble walking.
• Severe Skin Reactions: Rash, blistering/peeling skin, blue-gray discoloration (especially in the sun), increased sun sensitivity.
• Hyperthyroidism: Symptoms may include weight loss, anxiety, irritability, rapid heartbeat, heat intolerance, sweating, tremors, and difficulty sleeping.
• Hypothyroidism: Symptoms may include weight gain, fatigue, weakness, feeling cold, dry skin, hair loss, constipation, depression, difficulty concentrating, memory problems, and a slower heart rate.
• Vision Problems: Blurred vision, halos around lights, dry/sensitive eyes, any vision changes.
• Worsening or New Heart Rhythm Problems: Fast, slow, or pounding heartbeat, skipped beats, dizziness, lightheadedness, fainting, chest pain.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting amiodarone, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Cordarone should not be used if you have:
• Bradycardia leading to syncope: A history of slow heartbeats that have caused fainting unless a functioning artificial pacemaker is present. Cordarone can further slow the heart rate.
• Certain pre-existing lung problems: Amiodarone is generally contraindicated in patients with significant pre-existing lung disease, such as pulmonary fibrosis or interstitial lung disease, due to the high and potentially fatal risk of inducing or worsening pulmonary toxicity. In rare, life-threatening situations where no alternative is suitable, its use may be considered, but only after a specialist's comprehensive risk-benefit assessment and with intensive monitoring, acknowledging the heightened risk.
• Cardiogenic shock: A condition where the heart is severely weakened and cannot pump enough blood to meet the body's needs.
• Hepatitis: Active liver disease.
• Hypersensitivity: A known allergy to amiodarone or its components, including iodine.
• Second—or Third-Degree AV Block: This is a type of heart block in which the electrical signals from the heart's upper chambers (atria) are significantly or completely blocked from reaching the lower chambers (ventricles) unless a functioning artificial pacemaker is in place. Cordarone can worsen this condition.
• Severe Sinus Node Dysfunction: This includes conditions like sick sinus syndrome unless a functioning artificial pacemaker is in place. Cordarone can further suppress the heart's natural pacemaker.

Tell your doctor about all of your medical conditions, past and present, before starting generic amiodarone. This is crucial because certain conditions can affect whether generic amiodarone suits you. These conditions may include, but are not limited to:
• Known risk factors for Torsades de Pointes: Amiodarone can prolong the QT interval and increase the risk of this dangerous heart rhythm abnormality, especially in patients with congenital long QT syndrome or other risk factors.
• Pre-existing lung disease or reduced lung function: Cordarone can cause serious lung problems, and its use in patients with existing lung issues requires careful monitoring.
• Severe liver impairment: Cordarone can cause liver damage, and it may be contraindicated in patients with severe liver problems.
• Thyrotoxicosis: While Cordarone can cause hypothyroidism and hyperthyroidism, it may worsen thyrotoxicosis (overactive thyroid).

Drug Interactions:

Before taking amiodarone, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Details for: amiodarone - Drug and Health Product Register: https://hpr-rps.hres.ca/details.php?drugproductid=2169&query=

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with amiodarone. Amiodarone may interact with other medicines, but is not limited to:
• Certain antipsychotics: droperidol, pimozide, thioridazine, ziprasidone. These can also prolong the QT interval.
• Certain antibiotics: levofloxacin, moxifloxacin, pentamidine. Increased risk of QT prolongation and Torsades de Pointes.
• Cisapride: Increased risk of QT prolongation and Torsades de Pointes.
• Eliglustat: amiodarone increases eliglustat levels.
• Flibanserin: Increased risk of severe hypotension and syncope.
• Fingolimod: Increased risk of bradycardia, AV block, and Torsades de Pointes.
• Gonadotropin-Releasing Hormone (GnRH) Analogues (e.g., goserelin, histrelin, leuprolide): These medications can independently prolong the QT interval. Concomitant use with amiodarone, which also prolongs the QT interval, can have an additive effect on QT prolongation, increasing the overall risk of developing serious ventricular arrhythmias, including Torsades de Pointes. Close monitoring of the ECG is recommended.
• Lefamulin: Increased risk of QT prolongation.
• Lonafarnib: amiodarone increases lonafarnib levels.
• Lomitapide: amiodarone significantly increases lomitapide levels.
• Other antiarrhythmic drugs that prolong the QT interval: dofetilide, dronedarone, ibutilide, procainamide, quinidine, sotalol. These combinations can increase the risk of a dangerous heart rhythm problem called Torsades de Pointes.
• Potent CYP3A4 Inhibitors (including certain antifungals and antivirals): Drugs that strongly inhibit the cytochrome P450 3A4 enzyme, such as certain azole antifungals (e.g., fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole) and certain antiviral drugs (e.g., HIV protease inhibitors like indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir, and the COVID-19 antiviral nirmatrelvir/ritonavir), can significantly increase amiodarone plasma concentrations. This elevation in amiodarone levels can increase the risk of dose-related side effects, including cardiac toxicity (e.g., QT prolongation, Torsades de Pointes) and organ toxicities (e.g., pulmonary, hepatic, thyroid). Co-administration should generally be avoided or undertaken with extreme caution and close monitoring, often requiring a reduction in amiodarone dosage.
• Vernakalant: Increased risk of serious adverse cardiovascular effects, including QT prolongation and ventricular arrhythmias.

Drugs that May Require Dose Adjustment or Careful Monitoring When Used with Amiodarone:
• Beta-blockers (e.g., metoprolol, propranolol, carvedilol) and certain calcium channel blockers (e.g., verapamil, diltiazem): Increased risk of excessively slow heart rate (bradycardia) or heart block. Use with caution, especially in patients with pre-existing heart conditions.
• Blood thinners (anticoagulants): warfarin, apixaban, rivaroxaban. Amiodarone can increase the effects of these drugs, raising the risk of bleeding. The dose of the blood thinner usually needs to be reduced.
• Certain cholesterol-lowering drugs (statins): Amiodarone can increase the risk of muscle breakdown (myopathy and rhabdomyolysis), particularly with statins metabolized by CYP3A4 (e.g., simvastatin, atorvastatin, lovastatin). Rhabdomyolysis can potentially lead to kidney damage. Lower doses of these statins may be necessary, or alternative statins with different metabolic pathways (e.g., pravastatin, rosuvastatin) might be considered. Close monitoring for muscle pain, weakness, and liver function is essential.
• Cimetidine: Can increase amiodarone levels.
• Digoxin: Amiodarone can significantly increase digoxin levels, potentially leading to toxicity. The digoxin dose often needs to be halved.
• Drugs that affect electrolyte levels (e.g., diuretics, laxatives, corticosteroids, amphotericin B): Amiodarone can cause QT prolongation, and electrolyte imbalances (low potassium, magnesium, or calcium) can worsen this risk.
• Drugs metabolized by CYP3A4 or CYP2D6: Amiodarone can inhibit these liver enzymes, potentially increasing the levels and effects (or side effects) of many other drugs.
• Drugs for hepatitis C (e.g., sofosbuvir, ledipasvir): Can cause serious bradycardia.
• General anesthetics: Increased risk of hypotension and bradycardia during surgery.
• Levothyroxine: Amiodarone can affect thyroid function and may interact with thyroid hormone replacement therapy.
• Lidocaine, Flecainide, Propafenone: Amiodarone can increase the blood levels of these other antiarrhythmic drugs, potentially increasing their side effects and the risk of arrhythmias. Dose reductions may be necessary.
• Phenytoin/Fosphenytoin: Amiodarone can increase phenytoin levels, leading to toxicity.
• Tricyclic antidepressants (e.g., amitriptyline) and phenothiazines (e.g., chlorpromazine): Increased risk of serious arrhythmias.
• Trazodone: This antidepressant can independently cause QT interval prolongation. Concurrent use with amiodarone, which also prolongs the QT interval, carries an increased risk of additive QT prolongation and potentially serious ventricular arrhythmias, including Torsades de Pointes. Caution and ECG monitoring are advised.

Alcohol
While not a significant interaction, alcohol can sometimes affect heart rhythm or liver function, and it's generally wise to discuss alcohol consumption with your doctor while taking amiodarone.

Grapefruit
Grapefruit and grapefruit juice can significantly inhibit certain enzymes in the body, potentially leading to increased levels of amiodarone and a higher risk of side effects. Patients should generally avoid large amounts of grapefruit or grapefruit juice while taking amiodarone and discuss their grapefruit consumption with their doctor or pharmacist for personalized advice.

Pregnancy and Breastfeeding

Amiodarone carries a significant risk of harm to the fetus. It is generally contraindicated during pregnancy due to potential fetal thyroid dysfunction (both hypothyroidism and hyperthyroidism), bradycardia, and potential long-term neurodevelopmental effects. Its use in pregnancy should be avoided unless the life-threatening nature of the mother's arrhythmia outweighs the substantial risks to the fetus and no safer alternative is available. Amiodarone is excreted in breast milk and poses a risk of severe adverse effects, including thyroid abnormalities and cardiac issues, in the nursing infant. Therefore, breastfeeding is strictly contraindicated while taking amiodarone.

Frequently Asked Questions about Amiodarone at Canada Pharmacy Online:

Why is amiodarone more affordable in Canada than in the United States?

Prescription drug prices, including Cordarone, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Amiodarone 100 mg and 200 mg?

The difference in dosage represents the different amounts of the same active ingredient (amiodarone) present in each tablet.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of amiodarone at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Cordarone requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Cordarone?

Yes, there is a generic alternative for this product called amiodarone.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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