Depakene (Valproic Acid)

Type
Product
Manufacturer
Country
Dosage
Qty
Price(USD)
Type: drug type
Product: Depakene Oral Syrup
Manufacturer: BGP Pharma
Country: Canada
Dosage: 50 mg/ml/240 ml
Qty: 1
USD $55.00
Type: drug type
Product: Valproic Acid Oral Syrup
Manufacturer: Generic
Country: Canada
Dosage: 50 mg/ml/480 ml
Qty: 1
USD $65.00
Type: drug type
Product: Valproic Acid
Manufacturer: Generic
Country: Canada
Dosage: 250 mg
Qty: 100
USD $28.00

Depakene Information

Antiepileptic medication Depakene (valproic acid) is used as sole or adjunctive therapy in the treatment of simple or complex absence seizures, including petit mal, and is useful in primary generaliz (valproic acid) may also be used adjunctively in patients with multiple seizure types which include either absence or tonic-clonic seizures.

Simple absence is defined as a very brief clouding of the sensorium or loss of consciousness (lasting usually 2 to 15 seconds) accompanied by certain generalized epileptic discharges without other detectable clinical signs. Complex absence is the term used when other signs are also present.

Although the mechanism of Depakene (valproic acid) has not yet been established, the anticonvulsant activity of Depakene (valproic acid) may be related to increased brain concentrations of gamma-aminobutyric acid (GABA). The effect on the neuronal membrane is unknown.

Depakene Side Effects

antiepileptic medication Depakene side effects are nausea, vomiting and indigestion. Since Depakene antiepileptic medication (valproic acid)has usually been used with other antiepileptics, in most cases it is not possible to determine whether the adverse reactions mentioned are due to Depakene side effects or to the side effects of the combination of drugs. Gastrointestinal: Nausea, vomiting and indigestion are the most commonly reported side effects at the initiation of therapy. These effects are usually transient and rarely require discontinuation of therapy. Diarrhea, abdominal cramps and constipation have also been reported. Anorexia with some weight loss and increased appetite with some weight gain have also been observed. CNS Effects: Sedative effects have been noted in patients receiving DEPAKENE (valproic acid) alone, but are found most often in patients on combination therapy. Sedation usually disappears upon reduction of other antiepileptic medication. Ataxia, headache, nystagmus, diplopia, asterixis, "spots before the eyes", tremor, dysarthria, dizziness and incoordination have been noted rarely. Rare cases of coma have been reported in patients receiving valproic acid alone or in conjunction with phenobarbital. Dermatologic: Transient increases in hair loss have been observed. Skin rash and petechiae have rarely been noted. Endocrine: There have been reports of irregular menses and secondary amenorrhea in patients receiving valproic acid. Abnormal thyroid function tests have been reported (see Precautions). Psychiatric: Emotional upset, depression, psychosis, aggression, hyperactivity and behavioural deterioration have been reported. Musculoskeletal: Weakness has been reported. Hematopoietic: Thrombocytopenia has been reported. DEPAKENE (valproic acid) inhibits the second phase of platelet aggregation (see Precautions). This may be reflected in altered bleeding time. Bruising, hematoma formation and frank hemorrhage have been reported. Relative lymphocytosis and hypofibrinogenemia have been noted. Leukopenia and eosinophilia have also been reported. Anemia and bone marrow suppression have been reported. Hepatic: Minor elevations of transaminases [(e.g. AST(SGOT) and ALT(SGPT)] and LDH are frequent and appear to be dose related. Occasionally, laboratory tests also show increases in serum bilirubin and abnormal changes in other liver function tests. These results may reflect potentially serious hepatotoxicity (see Warnings). Metabolic: Hyperammonemia (see Precautions). Hyperglycinemia has been reported and associated with a fatal outcome in a patient with pre-existing nonketotic hyperglycinemia. Pancreatic: There have been reports of acute pancreatitis occurring in association with valproic acid therapy. Other: Edema of the extremities has been reported.

The generic alternative is not manufactured by the company that makes the brand product.

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