Depakote ER (Divalproex Sodium 24 Hour Tablet)

Name: Depakote ER
Brand: Sanofi Aventis
SKU: 6657
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Depakote ER

Manufacturer: Sanofi Aventis

Country: India

Dosage: 250 mg

Qty-Price (USD):

Type:

Product: Depakote ER (EXPIRY 11/25)

Manufacturer: Sanofi Aventis

Country: India

Dosage: 250 mg

Qty-Price (USD):

Type:

Product: Depakote ER

Manufacturer: Sanofi Aventis

Country: India

Dosage: 500 mg

Qty-Price (USD):

Type:

Product: Depakote ER

Manufacturer: Sanofi Aventis

Country: India

Dosage: 500 mg

Qty-Price (USD):

Generic Equivalent of Depakote ER

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Divalproex Sodium 24 Hour Tablet

Manufacturer: Generic

Country: India

Dosage: 250 mg

Qty-Price (USD):

Type:

Product: Divalproex Sodium 24 Hour Tablet

Manufacturer: Generic

Country: India

Dosage: 250 mg

Qty-Price (USD):

Type:

Product: Divalproex Sodium 24 Hour Tablet

Manufacturer: Generic

Country: India

Dosage: 500 mg

Qty-Price (USD):

Type:

Product: Divalproex Sodium 24 Hour Tablet (Dicorate ER - Sun Pharma)

Manufacturer: Generic

Country: India

Dosage: 750 mg

Qty-Price (USD):

Type:

Product: Divalproex Sodium 24 Hour Tablet (Dicorate ER - Sun Pharma)

Manufacturer: Generic

Country: India

Dosage: 1000 mg

Qty-Price (USD):

Depakote ER Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on April 1, 2026.

Depakote ER and Divalproex Sodium 24-Hour Tablet at CanadaPharmacyOnline.com

The manufacturer of brand-name Depakote ER (divalproex sodium extended-release tablets) is AbbVie Inc. Depakote ER is a specialized formulation that slowly releases the medication over 24 hours, allowing once-daily dosing. It is available in many countries worldwide, including India.

Generic divalproex sodium ER is widely available and produced by numerous reputable manufacturers that meet the strict standards of Health Canada and the FDA. Common generic producers include Apotex, Teva, Sandoz, and Dr. Reddy's. Generic divalproex ER is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on pharmacy inventory.

Important Information about Generic Divalproex Sodium

Generic divalproex sodium contains the same active ingredient as brand-name Depakote ER. It must meet the same effectiveness and quality standards. This means it is designed to work like Depakote ER. Studies have shown that generic divalproex sodium is bioequivalent to brand-name Depakote ER, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Depakote ER (divalproex sodium) is available in the following extended-release strengths:
• ER Tablets: 250 mg, 500 mg, 750 mg, and 1000 mg.

The dosage is highly individualized. Depakote ER is intended for once-daily dosing. It is not interchangeable with regular Depakote (delayed-release) tablets, which are usually taken multiple times a day.

Usage:

Depakote ER is primarily used to treat acute manic or mixed episodes associated with bipolar disorder and to prevent migraine headaches. It is also used as a standalone or add-on therapy for adults and children 10 years and older with certain types of seizures (complex partial seizures and absence seizures). Because it is an extended-release formula, it provides a steady level of medication in the blood throughout the day.

Mechanism of Action
Divalproex sodium, the active ingredient in Depakote ER, works by increasing the availability of a natural calming chemical in the brain. It is believed to increase gamma-aminobutyric acid (GABA) levels. GABA is a neurotransmitter that acts like a brake in the brain, slowing down nerve signals. By increasing GABA, the medication helps prevent the excessive and rapid firing of nerve cells that leads to seizures, manic highs, or the onset of a migraine. This stabilizing effect helps maintain a more consistent mood and reduces the brain's over-sensitivity to triggers.

Take Depakote ER exactly as your doctor prescribes, according to the product monograph. The tablets must be swallowed whole. Do not crush, chew, or break them, as this will disrupt the extended-release mechanism and cause too much medicine to be released at once.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Depakote ER, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Depakote ER (divalproex sodium). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Depakote ER; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Drowsiness or dizziness
• Increased appetite and weight gain
• Nausea or stomach pain
• Temporary hair loss
• Weakness or tremors

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Fetal Harm: Serious congenital disabilities if taken during pregnancy (see below).
• Hepatotoxicity (Liver Failure): Yellowing of the eyes/skin, dark urine, or severe pain in the upper right stomach (especially during the first 6 months).
• Hyperammonemia: Unexplained tiredness, vomiting, or changes in mental state (can indicate high ammonia levels).
• Pancreatitis: Severe stomach pain that spreads to your back, often with nausea and vomiting.
• Suicidal Thoughts: Increased risk of suicidal thinking or behavior.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Depakote ER, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Depakote ER/divalproex sodium if:
• Allergies: You have a known hypersensitivity to divalproex sodium
• Liver Disease: Significant hepatic impairment or urea cycle disorders.
• Mitochondrial Disorders: Specifically, Alpers-Huttenlocher syndrome.
• Pregnancy: It must not be used to prevent migraines in pregnant women.

Tell your doctor about all of your medical conditions, past and present, before starting Depakote ER. This is crucial as certain conditions affect the drug's safety.

Drug Interactions:

Before taking Depakote ER, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the medication guide at https://www.rxabbvie.com/pdf/dep3_medguide.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Depakote ER. Depakote ER may interact with other medicines, including but not limited to:
• Blood Thinners: May increase the risk of bleeding when taken with aspirin or warfarin.
• Other Seizure Medications: Can interact with phenytoin, carbamazepine, or lamotrigine, requiring dose adjustments.
• Topiramate: Combining these can increase the risk of high ammonia levels or low body temperature.

Pregnancy and Breastfeeding:

Depakote ER carries a Black Box Warning for pregnancy. It can cause major congenital disabilities (like spina bifida) and decreased IQ/developmental delays in the child. It should only be used for epilepsy or bipolar disorder if other treatments have failed. Divalproex sodium passes into breast milk in small amounts. While generally considered compatible, monitor the infant for jaundice or unusual bruising.

Use in Children:

Depakote ER is approved for certain types of seizures in children 10 years of age and older. It is generally not the first choice for younger children due to the higher risk of severe liver damage.

Frequently Asked Questions about Depakote ER at Canada Pharmacy Online

Why is Depakote ER more affordable in Canada than in the United States?

Prescription drug prices, including Depakote ER, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Depakote ER I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Depakote ER per prescription from your doctor.

Can I buy Depakote ER from you over the counter?

No, Depakote ER requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Depakote ER?

Yes, the generic divalproex sodium ER is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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