Dyazide (Triamterene/HCTZ)

Name: Dyazide
Brand: Generic
SKU: 2138
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no brand product of Dyazide.

Generic Equivalent of Dyazide

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Triamterene/HCTZ Tablet

Manufacturer: Generic

Country: Canada

Dosage: 50 mg/25 mg

Qty-Price (USD):

Dyazide Information

Triamterene/Hydrochlorothiazide at CanadaPharmacyOnline.com

The manufacturer of brand-name Dyazide (triamterene/hydrochlorothiazide) was GlaxoSmithKline but it is now owned globally by Teva Pharmaceuticals. The brand Dyazide is currently unavailable at this pharmacy.

Generic triamterene/hydrochlorothiazide is available at this pharmacy, manufactured in Canada by various manufacturers that meet Health Canada’s quality and safety standards. The specific manufacturer of your dispensed medication may vary based on pharmacy inventory.

Important Information about Generic Triamterene/Hydrochlorothiazide

Generic triamterene/hydrochlorothiazide contains the same active ingredients as brand-name Dyazide. It must meet the same effectiveness and quality standards. This means it is designed to work like Dyazide. Studies have shown that the generic is bioequivalent to brand-name Dyazide, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Dyazide (triamterene/hydrochlorothiazide) is available in the following oral strengths at this pharmacy:
• Tablets: 50 mg /25 mg oral tablets.

The usual dose is one tablet once or twice daily with food, as directed by your doctor. Doses should be taken in the morning to reduce the risk of nocturnal urination. Dosage should be adjusted according to your doctor’s instructions.

Usage:

Dyazide is a combination of two diuretics (water pills) indicated for the treatment of hypertension (high blood pressure) and edema (fluid retention) in patients who develop low potassium (hypokalemia) on hydrochlorothiazide alone. It is also suitable for patients taking digoxin (a heart medication) or those with a history of cardiac arrhythmias, where developing low potassium would be particularly risky. Triamterene helps the kidneys remove excess salt and water while preventing blood potassium levels from dropping too low. Hydrochlorothiazide is a water pill that increases urination to lower blood pressure and reduce swelling. Together, they work more effectively than hydrochlorothiazide alone, with less risk of potassium loss. Take Dyazide daily as directed by your doctor, preferably with food in the morning.

Mechanism of Action
Hydrochlorothiazide is a thiazide diuretic that acts in the kidney, at the distal convoluted tubule, to reduce the reabsorption of sodium and chloride, thereby increasing urination and lowering blood pressure. However, hydrochlorothiazide also causes the kidneys to lose potassium, which can lead to low potassium levels (hypokalaemia). Triamterene is a potassium-sparing diuretic that acts in a different part of the kidney—the late distal tubule and collecting duct—by blocking epithelial sodium channels (ENaC). These actions block the exchange of sodium for potassium, increasing sodium excretion while reducing potassium loss. By combining the two, Dyazide produces effective fluid removal and blood pressure lowering while helping to maintain normal potassium levels that would otherwise be depleted by hydrochlorothiazide alone.

Take Dyazide exactly as your doctor prescribes, according to the prescribing information. Take with food to reduce the risk of stomach upset.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Dyazide, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Dyazide (triamterene/hydrochlorothiazide). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Dyazide; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea, nausea, or stomach upset.
• Dizziness or headache
• Fatigue or weakness
• Increased urination
• Muscle cramps
• Photosensitivity (increased sensitivity to sunlight)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• High Potassium (Hyperkalemia): Muscle weakness, a slow or irregular heartbeat, or difficulty breathing. This is the most important serious risk of Dyazide, as it can cause fatal cardiac arrhythmias. Uncorrected high potassium can be life-threatening. The risk is higher in patients with kidney disease, diabetes, or who are elderly. Your doctor will monitor your potassium levels regularly.
• Kidney Stones (Nephrolithiasis): Flank pain, blood in the urine (hematuria), or difficulty urinating. Triamterene has been found in kidney stones and may increase the risk of stone formation. Report any signs of kidney stones to your doctor promptly.
• Low Blood Pressure (Hypotension): Severe dizziness or fainting, especially when standing up quickly (orthostatic hypotension). • Low Sodium (Hyponatremia) or Other Electrolyte Imbalances: Confusion, weakness, lethargy, or seizures.
• Non-Melanoma Skin Cancer (NMSC): Long-term hydrochlorothiazide use has been associated with an increased risk of basal cell carcinoma and squamous cell carcinoma due to its photosensitizing effects. Inspect your skin regularly and report any new or changing skin lesions to your doctor. Protect your skin from sunlight.
• Severe Allergic Reaction (Anaphylaxis): Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Worsening Kidney or Liver Function: Decreased urine output, rapid weight gain from fluid accumulation, or jaundice (yellowing of skin or eyes).

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Dyazide, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Dyazide/triamterene/hydrochlorothiazide if:
• Allergies: You have a known hypersensitivity to triamterene, hydrochlorothiazide, sulfonamide-derived drugs, or any tablet ingredient.
• Anuria: You are unable to produce urine.
• High Potassium (Hyperkalemia): You already have elevated potassium levels (greater than 5.5 mEq/L).
• Severe or Progressive Liver Disease: Triamterene is primarily metabolized by the liver; severe hepatic dysfunction is a contraindication due to the risk of hepatic encephalopathy.
• Severe Kidney Disease: Significant renal impairment (e.g., an estimated glomerular filtration rate [eGFR] <30 mL/min/1.73 m2); triamterene and HCTZ can cause dangerous potassium accumulation and are generally not recommended.

Tell your doctor about all of your medical conditions, past and present, before starting Dyazide. This is crucial as certain conditions affect the drug's safety.
• Diabetes — hydrochlorothiazide may raise blood glucose and affect glucose tolerance testing; triamterene may also affect folate metabolism
• Gout or high uric acid levels — hydrochlorothiazide may raise uric acid and trigger gout.
• Heart disease — particularly if you are taking digoxin; monitor potassium closely
• History of kidney stones — triamterene has been found in kidney stones; use with extra caution
• If you are on a low-salt diet
• Kidney or liver disease — dose adjustment and close monitoring required

Drug Interactions:

Before taking Dyazide, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00013078.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Dyazide. Dyazide may interact with other medicines, including but not limited to:
• ACE inhibitors and angiotensin receptor blockers (ARBs): These drugs raise potassium levels. Combining them with triamterene significantly increases the risk of dangerous hyperkalemia. Use with extreme caution and monitor potassium closely.
• Antidiabetic agents (insulin and oral hypoglycaemics): Hydrochlorothiazide may increase blood glucose levels. Antidiabetic drug requirements may need adjustment.
• Digoxin: Potassium levels affect how safely digoxin works in the heart. Hypokalemia drastically increases digoxin toxicity, while hyperkalemia can reduce its efficacy. The potassium-conserving effect of triamterene can be beneficial in this setting, but potassium levels must still be monitored closely.
• Folate supplements and methotrexate: Triamterene is a weak inhibitor of dihydrofolate reductase (the same enzyme targeted by methotrexate). Combining them can reduce folate levels and significantly increase the risk of severe methotrexate toxicity, including bone marrow suppression. Inform your doctor if you are taking either.
• Lithium: Hydrochlorothiazide reduces renal clearance of lithium, which can raise lithium levels to toxic concentrations. Concurrent use is generally not recommended.
• NSAIDs (e.g., ibuprofen, naproxen): Can reduce the diuretic and blood pressure-lowering effects of Dyazide and may precipitate acute kidney function decline.
• Other potassium-raising drugs (potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium): Must be avoided due to the risk of dangerous hyperkalemia.

Pregnancy and Breastfeeding:

Dyazide should be used during pregnancy only if the potential benefit justifies the risk to the unborn baby. Thiazide diuretics, including hydrochlorothiazide, cross the placental barrier and have been associated with fetal and neonatal jaundice and thrombocytopenia. Additionally, diuretics can reduce placental perfusion by depleting maternal blood volume. The routine use of diuretics in otherwise healthy pregnant women is not recommended. Consult your doctor if you are pregnant or planning to become pregnant.

Both hydrochlorothiazide and triamterene pass into breast milk. Breastfeeding is not recommended while taking Dyazide, as it may also suppress lactation. Discuss the risks and benefits with your doctor.

Use in Children:

The safety and efficacy of Dyazide in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Dyazide at Canada Pharmacy Online

Why is Dyazide more affordable in Canada than in the United States?

Prescription drug prices, including Dyazide, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Dyazide I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Dyazide per your doctor's prescription.

Can I buy Dyazide from you over the counter?

No, Dyazide requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Dyazide?

Yes, the generic alternative is available.

Blog Post:

Natural Ways to Lower Your Blood Pressure

Latest News:

Risk of skin cancer from hydrochlorothiazide and other diuretics across races: a global cohort study confirms increased non-melanoma skin cancer risk with cumulative HCTZ exposure – published in a peer-reviewed journal (published May 2026)

Similar Drugs in the category of Blood Pressure Medication:

Aldomet Catapres Corgard Proamatine Tribenzor

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

Reviews From Real Customers