Inhibace (Cilazapril)

Name: Inhibace
Brand: Xediton Pharmaceuticals
SKU: 6956
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Inhibace

Manufacturer: Xediton Pharmaceuticals

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Inhibace Plus (HCTZ)

Manufacturer: Xediton Pharmaceuticals

Country: Canada

Dosage: 5 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Inhibace Plus (HCTZ)

Manufacturer: Roche

Country: Turkey

Dosage: 5 mg/12.5 mg

Qty-Price (USD):

Generic Equivalent of Inhibace

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Cilazapril

Manufacturer: Generic

Country: Canada

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Cilazapril

Manufacturer: Generic

Country: Canada

Dosage: 2.5 mg

Qty-Price (USD):

Type:

Product: Cilazapril

Manufacturer: Generic

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Cilazapril Plus (HCTZ)

Manufacturer: Generic

Country: Canada

Dosage: 5 mg/12.5 mg

Qty-Price (USD):

Inhibace Information

CanadaPharmacyOnline.com supplies only genuine Inhibace from Turkey shipped using the Turkish packaging. This Inhibace is manufactured by Genetech Inc. (a member of Roche Group), the worldwide manufacturer of Inhibace. This offer is neither endorsed nor authorized by Genetech Inc. (the United States and Canadian distributor of Inhibace). CanadaPharmacyOnline.com has no affiliation whatsoever with Genetech Inc.

Inhibace and Cilazapril at CanadaPharmacyOnline.com

The manufacturer of brand-name Inhibace and Inhibace Plus (cilazapril) available at this pharmacy is Xediton Pharmaceuticals Inc. (Oakville, Ontario, Canada). Inhibace Plus is also available from Roche (Turkey). Roche originally developed Inhibace.

Generic cilazapril tablets are also available at this pharmacy. All generic products are manufactured in Canada by various manufacturers that meet Health Canada’s quality and safety standards. The specific manufacturer of your dispensed medication may vary based on pharmacy inventory.

Important Information about Generic Cilazapril and Generic Cilazapril/Hydrochlorothiazide

Generic cilazapril and generic cilazapril/hydrochlorothiazide contain the same active ingredients as brand-name Inhibace and Inhibace Plus, respectively. They must meet the same effectiveness and quality standards. This means they are designed to work like the brand-name products. Studies have shown that the generics are bioequivalent, meaning they have similar absorption and achieve comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Inhibace (cilazapril) and its generic equivalent are available in the following strengths:
• Inhibace: 5 mg oral tablets
• Generic cilazapril: 1 mg, 2.5 mg, and 5 mg oral tablets
• Inhibace Plus (Cilazapril/HCTZ): 5 mg /12.5 mg oral tablets

Dosage depends on your condition. Your doctor will determine the exact dose based on your body weight and the specific condition being treated. Cilazapril may be taken with or without food.

Usage:

Inhibace (cilazapril) is an angiotensin-converting enzyme (ACE) inhibitor indicated for the treatment of mild to moderate essential hypertension and for congestive heart failure as adjunctive therapy with digitalis and/or diuretics. Inhibace Plus (cilazapril/hydrochlorothiazide) is indicated for hypertension in patients for whom combination therapy is appropriate. It may be used as initial therapy or as a step-up when blood pressure is not adequately controlled on either component alone.

ACE inhibitors are a cornerstone of blood pressure and heart failure management. They are endorsed by the 2025 AHA/ACC Hypertension Guidelines as first-line antihypertensive agents, alongside ARBs, thiazide diuretics, and calcium channel blockers. Take Inhibace or Inhibace Plus daily as directed by your doctor, even when you feel well.

Mechanism of Action
Cilazapril is a prodrug that is rapidly converted in the body to its active form, cilazaprilat. Cilazaprilat works by blocking angiotensin-converting enzyme (ACE), which the body normally uses to convert angiotensin I into angiotensin II. Angiotensin II is a potent vasoconstrictor and stimulates aldosterone release. This hormone causes the body to retain salt and water. By blocking ACE, cilazapril reduces the formation of angiotensin II, allowing blood vessels to relax and widen, and reducing salt and water retention, both of which lower blood pressure. Blocking ACE also prevents the breakdown of bradykinin. This peptide further relaxes blood vessels but can cause a persistent dry cough in some patients.

In heart failure, these same actions reduce the heart's workload by lowering the pressure it pumps against and reducing excess fluid buildup in the body. This improves the heart’s efficiency and reduces symptoms such as breathlessness and ankle swelling.

Take Inhibace or Inhibace Plus exactly as your doctor prescribes, as directed in the product monograph. Cilazapril can be taken with or without food.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Inhibace or Inhibace Plus, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Inhibace/Inhibace Plus (cilazapril/cilazapril-hydrochlorothiazide). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Inhibace/Inhibace Plus; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Cough (dry, persistent)
• Dizziness or headache
• Fatigue
• Increased urination (with Inhibace Plus, from the HCTZ component)
• Nausea or stomach upset.
• Skin rash or itching

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Angioedema (Severe Allergic Swelling): Swelling of the face, lips, tongue, or throat, or sudden difficulty breathing or swallowing. This is a rare but potentially life-threatening reaction to ACE inhibitors. It can occur at any time, even after months or years of therapy. Stop taking Inhibace immediately and seek emergency care. Inhibace must never be restarted if you have experienced angioedema.
• High Potassium (Hyperkalemia): Muscle weakness or irregular heartbeat. ACE inhibitors reduce aldosterone, which can raise potassium levels, particularly in patients with kidney problems or those taking potassium supplements or potassium-sparing diuretics.
• Jaundice or Liver Problems: Yellowing of the skin or eyes, dark urine, or severe stomach pain. Rare cases of liver dysfunction have been reported with ACE inhibitors.
• Low Blood Pressure (Hypotension): Severe dizziness or fainting, especially after the first dose or in patients who are dehydrated or on diuretics. In patients with heart failure, the first dose must be given under close medical supervision.
• Signs of Infection (Agranulocytosis): Sore throat, fever, or mouth sores. Rarely, ACE inhibitors can reduce white blood cell counts. Report any signs of infection promptly, particularly in patients with kidney or immune system conditions.
• Worsening Kidney Function: Decreased urine output or significant swelling. ACE inhibitors can reduce blood flow to the kidneys, particularly in patients with narrowed kidney arteries or severe heart failure.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Inhibace or Inhibace Plus, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Inhibace/Inhibace Plus/cilazapril if:
• Allergies: You have a known hypersensitivity to cilazapril, hydrochlorothiazide, any other ACE inhibitor, or any ingredient in the tablet. For Inhibace Plus, also avoid if you have a known sulfonamide hypersensitivity (due to the HCTZ component).
• Angioedema History: You have a history of angioedema related to any previous ACE inhibitor treatment, or hereditary or unexplained angioedema.
• Diabetes with Aliskiren: You are taking aliskiren (Rasilez) and have diabetes. The combination of ACE inhibitors with aliskiren is contraindicated in diabetic patients.
• Pregnancy: See Serious Warnings and Pregnancy and Breastfeeding below.
• Sacubitril/Valsartan (Entresto): Do not take Inhibace within 36 hours of switching to or from sacubitril/valsartan, due to an increased risk of angioedema.

Tell your doctor about all of your medical conditions, past and present, before starting Inhibace. This is crucial as certain conditions affect the drug's safety.
• Diabetes
• Heart disease, including heart failure
• High potassium levels
• If you are on a low-salt diet
• Kidney disease (including if you have narrowing of the kidney arteries)
• Liver disease, including cirrhosis

Drug Interactions:

Before taking Inhibace or Inhibace Plus, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00046536.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Inhibace or Inhibace Plus. These medicines may interact with other medicines, including but not limited to:
• Aliskiren: Contraindicated in patients with diabetes or moderate-to-severe renal impairment. Generally not recommended for other patients.
• Antidiabetic agents (insulin and oral hypoglycemics): ACE inhibitors may enhance the blood sugar-lowering effect of antidiabetic drugs. Monitor blood glucose closely, particularly in the first weeks of treatment.
• Diuretics (water pills): May cause an excessive drop in blood pressure with the first dose. If possible, reduce or stop the diuretic before starting Inhibace.
• Lithium: ACE inhibitors reduce lithium excretion, raising lithium blood levels to potentially toxic concentrations. Concurrent use is generally not recommended.
• mTOR inhibitors (e.g., sirolimus, everolimus, temsirolimus): Increased risk of angioedema when combined with ACE inhibitors. Use with caution and close monitoring.
• NSAIDs (e.g., ibuprofen, naproxen): May reduce the blood pressure-lowering effect of Inhibace and can worsen kidney function.
• Other antihypertensive drugs: May cause additive blood pressure-lowering effects. Dose adjustments may be required.
• Potassium supplements or potassium-sparing diuretics (e.g., spironolactone, amiloride): May raise potassium to dangerous levels. Avoid unless specifically advised by your doctor.

Pregnancy and Breastfeeding:

Inhibace and Inhibace Plus are contraindicated during pregnancy. ACE inhibitors used during the second and third trimesters of pregnancy are known to cause serious fetal harm, including low blood pressure, skull abnormalities, reduced kidney function, anuria, and death in the newborn. Stop taking Inhibace or Inhibace Plus as soon as you know you are pregnant and contact your doctor immediately. Women of childbearing potential should use effective contraception while taking these medications.

Cilazapril passes into breast milk. Because of the potential for adverse effects in nursing infants, breastfeeding is not recommended during treatment with Inhibace or Inhibace Plus. Discuss the risks and benefits with your doctor.

Use in Children:

The safety and efficacy of Inhibace and Inhibace Plus in patients under 18 years of age have not been established. These medications are not recommended for use in children.

Frequently Asked Questions about Inhibace and Inhibace Plus at Canada Pharmacy Online

Why is Inhibace more affordable in Canada than in the United States?

Prescription drug prices, including Inhibace, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Inhibace I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Inhibace or Inhibace Plus per prescription from your doctor.

Can I buy Inhibace from you over the counter?

No, Inhibace and Inhibace Plus require a valid prescription from your doctor. We do not sell these products without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Inhibace?

Yes, the generic alternative is available.

Blog Post:

Natural ways to lower your blood pressure

Latest News:

2025 ACC/AHA Hypertension Guidelines: ACE inhibitors, including cilazapril, confirmed as preferred first-line antihypertensive agents for hypertension with heart failure with reduced ejection fraction, chronic kidney disease, and coronary artery disease – American Heart Association/American College of Cardiology (published September 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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