Sular 24 Hour Tablets (Nisoldipine)

Name: Sular 24 Hour Tablets
Brand: Bayer
SKU: 5611
Availability: InStock

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Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Sular 24 Hour Tablets (ON BACKORDER)

Manufacturer: Bayer

Country: Germany

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Sular 24 Hour Tablets (ON BACKORDER)

Manufacturer: Bayer

Country: Germany

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Sular 24 Hour Tablets (ON BACKORDER)

Manufacturer: Bayer

Country: Germany

Dosage: 30 mg

Qty-Price (USD):

Generic Equivalent of Sular 24 Hour Tablets

Type

Product

Manufacturer

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Qty-Price (USD)

There is no generic product of Sular 24 Hour Tablets.

Sular 24 Hour Tablets Information

Sular 24 Hour Tablets at CanadaPharmacyOnline.com

The manufacturer of brand-name Sular 24 Hour Tablets is Bayer. It is available in many countries worldwide, including Germany.

There is currently no generic equivalent available for Sular 24 Hour Tablets at this pharmacy.

Dosage:

Sular 24 Hour Tablets are available in the following oral strengths:
• Extended-release tablets: 10 mg, 20 mg, and 30 mg.

Dosage depends on individual condition and blood pressure response. Take nisoldipine at the same time each day on an empty stomach, one hour before or two hours after a meal.

Usage:

Sular 24 Hour Tablets (nisoldipine) is indicated for the treatment of hypertension, alone or in combination with other antihypertensive agents. The extended-release formulation allows once-daily dosing and provides smooth blood pressure control over 24 hours. Like other dihydropyridine CCBs (amlodipine, nicardipine), nisoldipine primarily acts on blood vessels with minimal direct effect on heart rate or cardiac conduction.

Mechanism of Action
Nisoldipine, the active ingredient in Sular, blocks L-type calcium channels in the walls of blood vessel smooth muscle, preventing calcium from entering the muscle cells. This relaxes and widens the blood vessels (vasodilation), reducing peripheral vascular resistance and lowering blood pressure. Because nisoldipine is highly selective for vascular smooth muscle over cardiac muscle, it has little effect on heart rate or conduction. The extended-release tablet uses a coat-core technology to release nisoldipine gradually over 24 hours.

Take Sular exactly as your doctor prescribes, according to the product monograph accompanying this medication. Swallow whole. Do not crush, break, or chew the tablet, as this can release the full dose at once and cause serious side effects. Avoid high-fat meals and grapefruit juice, as both can significantly raise nisoldipine blood levels.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Sular, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Sular 24 Hour Tablets (nisoldipine). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Sular; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Dizziness or headache
• Flushing or sensation of warmth
• Nausea
• Palpitations (awareness of heartbeat)
• Swelling of the ankles or feet (edema)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Heart Failure: Sudden weight gain, worsening breathlessness, or severe ankle swelling.
• Low Blood Pressure (Hypotension): Severe dizziness or fainting, especially when standing.
• Worsening Chest Pain (Paradoxical Angina / Myocardial Infarction): An increase in the frequency or severity of chest pain or risk of a heart attack when starting Sular or after a dose increase, particularly in patients with severe obstructive coronary artery disease. Seek emergency care if you experience chest pain.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Sular, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Sular/nisoldipine if:
• Allergies: You have a known hypersensitivity to nisoldipine, other dihydropyridines, or any tablet ingredient.
• Hypersensitivity to dihydropyridines: Cross-reactivity between dihydropyridine-class drugs may occur.

Tell your doctor about all of your medical conditions, past and present, before starting Sular. This is crucial as certain conditions affect the drug's safety (Conditions that require close medical monitoring or lower starting doses, as they are not absolute contraindications but affect safety):
• Aortic stenosis (increased risk of severe hypotension)
• Heart failure (may worsen peripheral edema or cardiac function)
• Severe hepatic impairment / Liver disease: Plasma levels can increase 4- to 5-fold; a lower starting dose and slower titration are required.
• Severe coronary artery disease (can provoke increased angina upon initiation or dose escalation)

Drug Interactions:

Before taking Sular, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please refer to the prescribing information at https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020356s027lbl.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Sular. Sular may interact with other medicines, including but not limited to: • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, nefazodone): Co-administration with strong CYP3A4 inhibitors is generally contraindicated or requires extreme caution as they dramatically increase nisoldipine exposure.
• CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine, St. John's Wort): Co-administration with strong CYP3A4 inducers should be avoided, as they can reduce nisoldipine levels to near undetectable amounts, completely nullifying blood pressure control.
• Grapefruit juice: Substantially increases nisoldipine blood levels. Avoid completely.
• Other antihypertensives: Additive blood-pressure-lowering effects.

Pregnancy and Breastfeeding:

Nisoldipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited data exist on human pregnancies, but animal reproduction studies have shown fetal risk. It is recommended to discontinue breastfeeding while taking this medication, as it is unknown if it passes into human breast milk.

Use in Children:

The safety and efficacy of Sular in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Sular 24 Hour Tablets at Canada Pharmacy Online

Why are Sular 24 Hour Tablets more affordable in Canada than in the United States?

Prescription drug prices, including Sular 24 Hour Tablets, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Sular 24 Hour Tablets I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Sular 24 Hour Tablets per your doctor’s prescription.

Can I buy Sular 24 Hour Tablets from you over the counter?

No, Sular 24 Hour Tablets require a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Sular 24 Hour Tablets?

The generic alternative is currently unavailable (at this pharmacy).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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