Trulance (Plecanatide)

Name: Trulance
Brand: Bausch Health
SKU: 7738
Availability: InStock

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Product

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Qty-Price (USD)

Type:

Product: Trulance Tablet

Manufacturer: Bausch Health

Country: Canada

Dosage: 3 mg

Qty-Price (USD):

Generic Equivalent of Trulance

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There is no generic product of Trulance.

Trulance Information

medically reviewed by Carol Hou (BSc. Pharm) on August 13, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Trulance at CanadaPharmacyOnline.com

Trulance (plecanatide) is manufactured and distributed by Bausch Health globally, including Canada.

Generic plecanatide is currently unavailable (at this pharmacy).

Dosage

Trulance (plecanatide) is available as a single-strength 3 mg oral tablet.

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage

Trulance (plecanatide) is a prescription medication used in adults to treat certain types of constipation, including Irritable Bowel Syndrome with Constipation (IBS-C), a chronic condition characterized by abdominal pain and constipation, and chronic Idiopathic Constipation (CIC), Long-lasting constipation where the cause is unknown.

Mechanism of Action
Trulance (plecanatide) is a guanylate cyclase-C (GC-C) agonist. It is structurally similar to uroguanylin, a naturally occurring peptide in the gastrointestinal tract. Plecanatide binds to and activates GC-C receptors on the luminal surface of intestinal epithelial cells. This activation leads to an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP). The increase in cGMP stimulates the secretion of chloride and bicarbonate into the intestinal lumen. It decreases sodium reabsorption, leading to an influx of water into the intestines. This increase in intestinal fluid helps to soften stools, increase bowel movement frequency, and reduce abdominal pain and bloating associated with IBS-C and CIC. Trulance acts locally in the upper gastrointestinal tract with minimal systemic absorption.

Take Trulance exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Trulance, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Trulance, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Trulance; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal pain
• Abdominal distension (bloating)
• Diarrhea (most common, usually mild)
• Dizziness
• Flatulence (gas)
• Nausea
• Upper respiratory tract infection (e.g., common cold)
• Urinary tract infection (UTI)

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Severe Diarrhea: Although usually mild, diarrhea can be severe and lead to significant fluid and electrolyte loss and dehydration. Symptoms of dehydration can include excessive thirst, dry mouth, decreased urination, and confusion. If severe diarrhea occurs, stop taking Trulance and contact your doctor immediately.
• Serious Dehydration in Children: Trulance is contraindicated in children less than 6 years of age due to the risk of severe dehydration, which was fatal in juvenile mice in non-clinical studies. Use should be avoided in children 6 years of age or younger due to a lack of safety and efficacy data and potential risks.
• Allergic Reaction: Although rare, symptoms can include rash, itching, hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Increased Liver Enzymes: Rarely, increased levels of liver enzymes have been observed in blood tests. However, liver problems were not reported in clinical studies.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Trulance, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Trulance should not be used if:
• You are allergic to plecanatide or any other ingredient in Trulance.
• You are less than 6 years of age due to the risk of severe dehydration.
• You have a known or suspected mechanical gastrointestinal obstruction.

Tell your doctor about all of your medical conditions, past and present, before starting Trulance. This is crucial because certain conditions affect whether Trulance is right for you. These conditions may include, but are not limited to:
• Any history of severe diarrhea.
• Any known or suspected bowel blockage or intestinal obstruction.
• Any other medical conditions, especially those related to the gastrointestinal tract.

Drug Interactions

Before taking Trulance, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the Trulance prescribing information | Bausch Health.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Trulance. Due to minimal systemic absorption, Trulance has few known significant drug interactions. However, caution should be exercised with:
• Laxatives or other medications that affect bowel function: Concomitant use with other laxatives or strong purgatives may increase the risk of diarrhea or other gastrointestinal side effects.
• Medications that can cause dehydration: Diuretics or other drugs that can lead to fluid loss might increase the risk of dehydration if severe diarrhea occurs.

Pregnancy and Breastfeeding

Trulance is not expected to result in fetal exposure to the drug due to negligible systemic absorption after oral administration. Animal studies have shown no effects on embryo-fetal development, fertility, or reproductive function. However, there are no adequate and well-controlled studies in pregnant women. Trulance should be used during pregnancy only if needed.

It is unknown whether plecanatide is excreted in human milk. However, due to negligible systemic absorption, it is unlikely to be present in breast milk or cause adverse effects in a breastfed infant. No special precautions are typically required for breastfeeding mothers. Consult your doctor for personalized advice.

Use in the Elderly

No overall differences in safety or effectiveness have been observed between elderly patients and younger patients in clinical studies. However, elderly patients may be more susceptible to the effects of fluid and electrolyte imbalances that can result from severe diarrhea. Therefore, caution and close monitoring for dehydration are advised in this population.

Use in Children

Trulance is contraindicated in patients less than 6 years of age due to the risk of severe dehydration. Use of Trulance should be avoided in patients aged 6 years or younger than 18 years of age. The safety and effectiveness of Trulance in pediatric patients less than 18 years of age have not been established.

Frequently Asked Questions about Trulance at Canada Pharmacy Online:

Why is Trulance more affordable in Canada than in the United States?

Prescription drug prices, including Trulance, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Trulance at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Trulance requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the best time to take Trulance?

Trulance is typically taken once daily, with or without food, as directed by your doctor. It can be taken at any time of day. However, it's often recommended to take it at a consistent time to help establish a routine.

Blog Posts:

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Latest News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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