Uniphyl (Theophylline SR 24 HR)

Name: Uniphyl
Brand: Napp Pharmaceuticals
SKU: 2154
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Uniphyl

Manufacturer: Napp Pharmaceuticals

Country: United Kingdom

Dosage: 300 mg

Qty-Price (USD):

Generic Equivalent of Uniphyl

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Theophylline SR 24 HR

Manufacturer: Generic

Country: Canada

Dosage: 400 mg

Qty-Price (USD):

Type:

Product: Theophylline SR 24 HR

Manufacturer: Generic

Country: Canada

Dosage: 600 mg

Qty-Price (USD):

Uniphyl Information

medically reviewed by Carol Hou (BSc. Pharm) on May 7, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Uniphyl and Theophylline SR 24 HR at CanadaPharmacyOnline.com

Brand Uniphyl (Theophylline SR 24 HR), manufactured by Napp Pharmaceuticals in the United Kingdom.

Generic Theophylline SR 24 HR is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Theophylline SR 24 HR:

Generic Theophylline SR 24 HR contains the same active ingredient as brand-name Uniphyl and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Uniphyl. Studies have demonstrated similar absorption rates, but individual responses can still vary due to various factors. Talk to your doctor or pharmacist if you have any questions about Theophylline SR 24 HR.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Brand Uniphyl 24 HR is available in a strength of 300 mg oral extended-release tablets. Generic Theophylline 24 HR is commonly available in the strengths of 400 mg and 600 mg oral extended-release tablets (at this pharmacy).

Your doctor will determine the safe and effective dosage based on your individual needs.

Usage:

Uniphyl is a prescription medication used to help people with asthma or COPD breathe easier. (source: product monograph in Canada)

Mechanism of Action:
Uniphyl (Theophylline SR 24 HR) is a bronchodilator that inhibits phosphodiesterase (PDE) enzymes, leading to increased intracellular cyclic adenosine monophosphate (cAMP) concentrations, which promote smooth muscle relaxation in the airways. Additionally, theophylline functions as an adenosine receptor antagonist, mitigating adenosine-induced bronchoconstriction. Furthermore, it demonstrates anti-inflammatory properties by activating histone deacetylase (HDAC) and reducing the release of inflammatory mediators. These combined actions contribute to theophylline's therapeutic efficacy in managing bronchospastic disorders like asthma and COPD, although its narrow therapeutic index necessitates careful monitoring.

It is crucial to take Uniphyl exactly as your doctor prescribes and read the drug label information | DailyMed. Consult your doctor for personalized guidance and safe use.

Side Effects:

The information below is a summarizes some, but not all, potential side effects, risks, and interactions. Before starting Uniphyl, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Common side effects – These are some frequently reported side effects of Uniphyl (Theophylline SR 24 HR), but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or if you experience any other concerning symptoms.
• Nausea
• Vomiting
• Diarrhea
• Headache
• Insomnia (difficulty sleeping)
• Irritability
• Tremors (shakiness)
• Increased heart rate

Serious side effects: Stop taking Uniphyl and seek immediate medical attention if you experience any of the following:
• Seizures
• Cardiac arrhythmias (irregular heartbeat, including rapid heartbeat)
• Severe vomiting (potentially leading to dehydration and electrolyte imbalances)
• Severe abdominal pain
• Status epilepticus (prolonged or repeated seizures)
• Sudden death (rare)

Individual reactions can vary. It is crucial to discuss potential side effects and risks with your doctor for a complete and up-to-date list.

Contraindications:

The following is a partial list of contraindications. Before starting Uniphyl, it is crucial to discuss all your medical conditions, past and present, and all the medications you are taking with your doctor or pharmacist.

Uniphyl (Theophylline SR 24 HR) is CONTRAINDICATED in the following situations and should not be used if:
• Hypersensitivity: Known hypersensitivity (allergy) to theophylline or any of its components.
• Active Peptic Ulcer Disease: Theophylline can increase gastric acid secretion and may exacerbate ulcers.
• Uncontrolled Seizure Disorders: Theophylline can lower the seizure threshold and increase the risk of seizures.
• Certain Cardiac Arrhythmias: Patients with pre-existing, unstable cardiac arrhythmias (irregular heartbeats) should generally avoid theophylline, as it can worsen these conditions.
• Acute Myocardial Infarction (Heart Attack): Theophylline should be used with caution, if at all in the acute phase of a heart attack due to its potential to increase heart rate and myocardial oxygen demand.

Inform your doctor if you have any of the following pre-existing medical conditions, as they may affect whether Uniphyl is right for you:
• Severe Liver Disease: Theophylline is metabolized by the liver, and impaired liver function can lead to increased drug levels and toxicity.
• Severe Renal Disease: While theophylline is primarily metabolized by the liver, severe kidney disease can affect its clearance indirectly.
• Hyperthyroidism: Theophylline can exacerbate symptoms of hyperthyroidism, such as increased heart rate.
• Cystic Fibrosis: These patients may have altered theophylline pharmacokinetics.

Drug Interactions:

Before taking Uniphyl, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete information about potential drug interactions, consult the official Uniphyl prescribing information (package insert): https://pdf.hres.ca/dpd_pm/00057795.PDF

Drugs that can INCREASE Theophylline Levels (increasing the risk of side effects):

CYP1A2 Inhibitors:
• Fluoroquinolone antibiotics: Ciprofloxacin, enoxacin
• Macrolide antibiotics: Erythromycin, clarithromycin (azithromycin has less effect)
• Antifungals: Ketoconazole, fluconazole
• Cimetidine: An H2 receptor antagonist (used for stomach acid)
• Allopurinol: Used for gout
• Oral contraceptives:
• Ticlopidine: An antiplatelet drug
• Zileuton: A leukotriene inhibitor (used for asthma)
• Febuxostat: Used for gout
• Grapefruit juice: While some sources suggest minimal interaction, it's often advised to consume consistently or avoid due to potential variability.

CYP3A4 Inhibitors:
• Macrolide antibiotics: Erythromycin, clarithromycin
• Calcium channel blockers: Verapamil, diltiazem

Drugs that can DECREASE Theophylline Levels (reducing effectiveness):

CYP1A2 Inducers:
• Smoking (tobacco, marijuana): This is a significant inducer.
• Rifampin: An antibiotic used for tuberculosis.
• Phenytoin, phenobarbital, carbamazepine: Anticonvulsants.
• St. John's Wort: A herbal supplement.

Other notable Interactions:

• Beta-adrenergic agonists (e.g., albuterol, salmeterol): Increased risk of cardiovascular side effects (tachycardia, arrhythmias).
• Diuretics: Increased risk of electrolyte imbalances, especially hypokalemia.
• Corticosteroids: May have additive effects but also potential for increased side effects.
• Lithium: Theophylline can decrease lithium levels.
• Benzodiazepines: Theophylline can antagonize the sedative effects of benzodiazepines.
• Neuromuscular blocking agents: Theophylline can potentially affect the duration of action of some neuromuscular blockers.

Pregnancy or Breastfeeding:

If you're pregnant or breastfeeding and need help with your breathing from asthma or COPD, it's really important to talk to your doctor about Uniphyl. This medicine can pass on to your baby during pregnancy and through breast milk, and there are some concerns about potential effects. Your doctor will carefully weigh the benefits of you taking Uniphyl against any possible risks to your baby. Sometimes, other breathing medicines that might be safer during this time could be a better option. If Uniphyl is the best choice for you, your doctor will keep a close eye on your medicine levels and your baby's health. The goal is to find the safest way to keep you healthy while protecting your little one.

Infants under 6 months of age: Theophylline metabolism is unpredictable in this age group.

Frequently Asked Questions about Uniphyl at Canada Pharmacy Online:

Why is Uniphyl more affordable in Canada than in the United States?

Prescription drug prices, including Uniphyl, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on getting you the lowest prices on high quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Uniphyl tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Uniphyl at one time, as per your doctor’s prescription.

Can I buy Uniphyl over the counter from you?

No, Uniphyl requires a prescription from your doctor. We are unable to sell this product without a valid prescription from your doctor.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Blog Posts:

The Surprising Connection Between Asthma and Oral Health

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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