Vyzulta (Latanoprostene Bunod)

Name: Vyzulta
Brand: Bausch & Lomb
SKU: 7549
Availability: InStock

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Qty-Price (USD)

Type:

Product: Vyzulta

Manufacturer: Bausch & Lomb

Country: Canada

Dosage: 0.024 %/5 ml

Qty-Price (USD):

Generic Equivalent of Vyzulta

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There is no generic product of Vyzulta.

Vyzulta Information

medically reviewed by Carol Hou (BSc. Pharm) on June 23, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Vyzulta at CanadaPharmacyOnline.com

Brand Vyzulta, manufactured by Bausch & Lomb, is available in many countries, including Canada.

The generic latanoprostene bunod is currently unavailable (at this pharmacy).

Dosage:

Vyzulta is an ophthalmic solution containing 0.024% w/v of latanoprostene bunod, equivalent to 0.24 mg/mL. It is available in an eye-drop dispenser with a 5 mL fill volume (often in a 7.5 mL bottle).

Your doctor will determine the appropriate dosage based on the individual needs and medical conditions.

Usage:

Vyzulta (latanoprostene bunod) is a prescription eyedrop used to treat high eye pressure due to open-angle glaucoma or ocular hypertension.

For more information, please visit the FDA: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207795Orig1s000lbl.pdf

Mechanism of Action:
Vyzulta (latanoprostene bunod) belongs to the prostaglandin analog class of medications. It works by targeting both primary and secondary aqueous humor outflow pathways. Upon ocular administration, latanoprostene bunod is rapidly hydrolyzed into two active moieties: latanoprost acid and nitric oxide (NO). This synergistic action on both outflow routes contributes to Vyzulta's efficacy in lowering IOP for patients with open-angle glaucoma or ocular hypertension.

Use Vyzulta exactly as your doctor prescribes. Do not change your dosage or stop using the medication without consulting your doctor. Follow the instructions in the product monograph in Canada: https://pdf.hres.ca/dpd_pm/00048990.PDF.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before using Vyzulta, it is essential to discuss all potential side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

Below is a partial list of side effects; individual reactions can vary. Before starting Vyzulta, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects – These are examples of some common side effects of Vyzults, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Eye redness (conjunctival hyperemia): This is the most frequently reported side effect. It's often most noticeable when you use the drops and may lessen over time. Taking the drops at bedtime can make the redness less apparent.
• Eye irritation, pain, or stinging: You might feel a burning or stinging sensation immediately after applying the drops. This can also include a feeling of grittiness or like something is in your eye. These symptoms can be related to the preservative (benzalkonium chloride or BAK) in the drops.
• Eyelash changes: Over time, Vyzulta can cause your eyelashes to become longer, thicker, darker, or even increase in number. It can also affect the direction of eyelash growth. These changes are usually reversible if you stop the medication.
• Darkening of the eyelid skin: The skin around your eyes may also become darker. This is usually reversible.

Serious or rare side effects – Stop using Vyzulta and seek immediate medical attention right away if you experience any of the following:
• Allergic reaction: Although rare, some people may experience an allergic reaction to Vyzulta, with symptoms like hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. If you experience these severe symptoms, seek immediate medical attention.
• Bacterial keratitis (eye infection): This is not a direct side effect of the medication itself, but rather a risk if the dropper tip becomes contaminated. Always avoid touching the tip of the bottle to your eye or any other surface.
• Blurred vision: While common, some people may experience temporary blurry vision.
• Changes in iris color (eye color): Vyzulta can gradually increase the brown pigment in the iris (the colored part of your eye). This change can be permanent, especially in people with mixed-colored eyes (e.g., blue-brown, green-brown). It can take months or years to become noticeable, and if only one eye is treated, it could result in a cosmetic difference between your eyes.
• Eye inflammation (iritis/uveitis): Vyzulta should be used with caution in patients with a history of eye inflammation. It is generally avoided if there is active inflammation, as it can worsen the condition.
• Macular edema: This is swelling and fluid buildup in the central part of the retina, which can affect vision. It's more of a concern for individuals with specific risk factors, such as those without a natural lens in their eye or with a torn posterior lens capsule.

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are using with your doctor or pharmacist before starting Vyzulta.

Vyzulta should not be used if:
• Hypersensitivity to the active substance (latanoprostene bunod) or any of the excipients in the formulation, including benzalkonium chloride (BAK). If you have a known allergy to Vyzulta or any of its ingredients, you should not use this medication, as it could lead to a severe allergic reaction.

Tell your doctor about all of your medical conditions, past and present, before starting Vyzulta. This is crucial because certain conditions affect whether Vyzulta is right for you. These conditions may include, but are not limited to:
• Active Intraocular Inflammation (e.g., iritis/uveitis): Vyzulta should be used with caution in patients with a history of intraocular inflammation and should generally be avoided if there is active inflammation, as it may exacerbate the condition.
• Contact Lenses: Vyzulta contains benzalkonium chloride (BAK), which can be absorbed by soft contact lenses. Contact lenses must be removed before administering Vyzulta and can be reinserted 15 minutes after application.
• History of Herpetic Keratitis: While not an absolute contraindication, caution is often advised in patients with a history of ocular herpes simplex virus (HSV) infection, as prostaglandin analogs might reactivate the virus.
• Macular Edema Risk Factors: Caution is advised in patients at risk for macular edema, such as those who are aphakic (no natural lens in the eye), pseudophakic with a torn posterior lens capsule, or those with known risk factors for macular edema (e.g., diabetic retinopathy).

Drug Interactions:

Before using Vyzulta, discussing all potential risks and interactions with your doctor or pharmacist is essential. For complete information about potential drug interactions, please consult the product information on Bauch & Lomb’s website at https://www.bausch-payersolutions.com/vyzulta/. Discuss any concerns with your healthcare provider.

Always inform your doctor about all medications you are taking, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. This is crucial as Vyzulta may interact with other medicines, such as:
• Other Ophthalmic Prostaglandin Analogs: Using Vyzulta concurrently with other prostaglandin eye drops for glaucoma (e.g., bimatoprost, latanoprost, omidenepag isopropyl, tafluprost, travoprost, unoprostone ophthalmic) may lead to increased intraocular pressure or reduced effectiveness.
• Other Topical Ophthalmic Products: To ensure proper absorption and avoid dilution, administer other eye drops at least 5 minutes apart from Vyzulta.

Pregnancy and Breastfeeding:

If you are pregnant or plan to become pregnant, tell your doctor before using Vyzulta. The safety and effectiveness of Vyzulta have not been established. It is crucial to discuss the risks and benefits of using Vyzulta with your doctor before using it.

Also, if you are breastfeeding or plan to breastfeed, inform your doctor. It is unknown if latanoprostene bunof is excreted in human breast milk. Because there's a potential risk for serious side effects in breastfed infants, you and your doctor should decide whether to stop breastfeeding or stop using Vyzulta.

Use in Children:

Vyzulta is generally not recommended for children aged 16 and younger. This is mainly because of concerns about the medication's long-term effects on developing eyes, specifically the potential for permanent changes in eye color (iris pigmentation) and eyelash alterations. Always consult your child’s doctor for the most appropriate and safest treatment.

Frequently Asked Questions about Vyzulta at Canada Pharmacy Online

Why is Vyzulta more affordable in Canada than in the United States?

Prescription drug prices, including Vyzulta, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs than the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on getting you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about the ordering process, please visit our How to Order page.

Does Vyzulta need to be refrigerated?

Unopened bottles should be refrigerated at 2° to 8°C (36° to 46°F), but once opened, they can be stored at 2° to 25°C (36° to 77°F) for 8 weeks. During shipment, bottles may be maintained at temperatures up to 40°C for a period not exceeding 14 days.

When is the best time of the day to use Vyzulta?

According to the official website, Vyzulta should be used once daily at night around the same time every night to help ensure the medication is working effectively. Do not use Vyzulta more than once daily.

Is there a limit on how much Vyzulta I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Vyzulta at once, per your doctor's prescription.

Can I buy Vyzulta over the counter from you?

No, Vyzulta requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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