Dilantin (Phenytoin)

Name: Dilantin
Brand: Viatris
SKU: 0376
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Dilantin

Manufacturer: Viatris

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Dilantin Suspension

Manufacturer: Viatris

Country: Canada

Dosage: 30 mg/5 ml/250 ml

Qty-Price (USD):

Type:

Product: Dilantin

Manufacturer: Viatris

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Dilantin Suspension

Manufacturer: Viatris

Country: Canada

Dosage: 125 mg/5ml/250 ml

Qty-Price (USD):

Generic Equivalent of Dilantin

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Phenytoin

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Phenytoin

Manufacturer: Generic

Country: India

Dosage: 100 mg

Qty-Price (USD):

Dilantin Information

medically reviewed by Carol Hou (BSc. Pharm) on June 13, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Dilantin and Phenytoin at CanadaPharmacyOnline.com

Brand Dilantin, manufactured by Viatris, is available in Canada and India.

Generic phenytoin is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important information about Generic Phenytoin:

Generic phenytoin contains the same active ingredient as the brand-name Dilantin, and meets the same effectiveness, safety, and quality standards. This means it is designed to work in the same way as Dilantin. While specific bioequivalence studies are conducted to ensure generic medications have comparable absorption rates and overall effects, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have any questions about generic phenytoin.

For information about generic drug approval and bioequivalence, please visit the FDA website: https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs

Dosage:

Brand Dilantin is commonly available in the following strengths and forms (at this pharmacy):
• 30 mg and 100 mg oral extended-release capsules
• 30 mg/5 ml and 125 mg/5 ml oral suspension, packed in a 250 ml bottle.

Phenytoin is commonly available in 100 mg oral extended-release capsules.

Your doctor will determine the appropriate dose based on your needs and medical condition.

Usage:

Dilantin (phenytoin) is a prescription medication primarily used to help control and prevent certain types of seizures in adults and children with epilepsy. It's particularly effective for common seizure types like tonic-clonic (grand mal) and complex partial seizures.

For more information, please visit the Dilantin patient medication information | Viatris.ca: https://www.viatris.ca/-/media/project/common/global/pdfs/en-ca/dilantin-caps-patient-information---english.pdf

Mechanism of Action:
Dilantin (phenytoin) exerts its anticonvulsant effects primarily by modulating neuronal excitability through its interaction with voltage-gated sodium channels. Specifically, it binds to these channels in their inactive state, thereby prolonging their refractory period and limiting the capacity of neurons to fire at high frequencies. This medication works by stabilizing the electrical activity in the brain, which helps to calm overactive nerve cells that can trigger seizures.

Dilantin can also be used to prevent seizures that might occur during or after brain surgery. It's crucial to remember that Dilantin is a long-term treatment, and it should never be stopped suddenly, as this could lead to more frequent or severe seizures; always follow your doctor's instructions carefully.

Use Dilantin exactly as your doctor prescribes. Do not change your dosage or stop using the medication without consulting your doctor. Follow the instructions in the product monograph in Canada: https://pdf.hres.ca/dpd_pm/00046493.PDF.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Dilantin, it is essential to discuss all possible aspects with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Dilantin, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects: These are examples of some common side effects of Dilantin, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Gastrointestinal effects:
o Constipation
o Nausea
o Vomiting
• Nervous system effects:
o Confusion
o Dizziness
o Drowsiness or tiredness
o Headache
o Irregular movement of the eye (nystagmus)
o Nervousness or insomnia (trouble sleeping)
o Problems with walking and coordination (ataxia)
o Slurred speech
o Tremor
• Oral health:
o Swollen, tender, or bleeding gums (gingival hyperplasia) – Good oral hygiene can help prevent this.
• Skin:
o Skin rash (most are not serious, but any new rash should be reported)

Serious or rare effects: Stop taking Dilantin and seek immediate medical attention if you experience any of the following:
• Allergic Reactions:
o Difficulty breathing
o Hives, rash, severe itching
o Swelling of the face, lips, tongue, or throat
• Blood Disorders:
o Fever, chills, sore throat, or other signs of infection (could indicate low white blood cell count)
o Unusual bruising or bleeding (e.g., easy bruising, petechiae)
o Unusual tiredness or paleness (could indicate anemia)
• Bone Health:
o Softening of bones (osteopenia, osteoporosis), increasing the risk of fractures with long-term use. • Cardiac Problems: o Slow or irregular heartbeats, chest pain, dizziness, or fainting (especially if Dilantin is given too quickly intravenously)
• High Blood Sugar (Hyperglycemia):
o Increased thirst, frequent urination, fatigue, blurred vision.
• Liver Problems:
o Dark urine, pale stools
o Loss of appetite, upper stomach pain
o Nausea or vomiting
o Yellowing of the skin or eyes (jaundice)
• Mental Health Changes:
o New or worsening depression, anxiety, agitation, restlessness, panic attacks, or changes in mood or behavior.
o Thoughts of suicide or self-harm.
• Severe Skin Reactions: These are rare but can be life-threatening and include:
o Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS syndrome): This can involve a skin rash, fever, swollen lymph nodes, and may affect multiple organs.
o Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): Symptoms often start with flu-like symptoms followed by a red or purple rash that spreads and forms blisters, leading to skin peeling.

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Dilantin should not be used if:
• Certain Cardiac Conditions (for intravenous administration): While less common for oral use, for intravenous administration of phenytoin, certain pre-existing heart conditions are contraindications due to the risk of serious cardiac adverse events (e.g., hypotension, arrhythmias, asystole). These include Sinus bradycardia (slow heart rate), Sinoatrial block, Second and third-degree atrioventricular (AV) block, and Adams-Stokes syndrome
• Coadministration with Delavirdine: Phenytoin is contraindicated for concurrent use with delavirdine (an antiretroviral medication used to treat HIV). Phenytoin can significantly decrease the levels of delavirdine, leading to a loss of virologic response and potential development of drug resistance.
• History of Phenytoin-Induced Liver Damage: If a patient has previously experienced liver problems or acute hepatotoxicity specifically attributed to phenytoin, re-exposure to the drug is contraindicated due to the risk of recurrence and severe liver damage.
• Hypersensitivity/Allergy: A history of allergy or hypersensitivity to phenytoin itself, any of its inactive ingredients, or other drugs belonging to the hydantoin class (like ethotoin, fosphenytoin, or mephenytoin). Allergic reactions can be severe and life-threatening, including Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS syndrome).
Tell your doctor about all your medical conditions, past and present, before starting Dilantin. This is crucial because certain conditions can affect whether Dilantin is right for you. These conditions may include, but are not limited to:
• Asian Ancestry and HLA-B*1502 Allele: Patients of Asian ancestry should be screened for the HLA-B*1502 allele before starting phenytoin, as its presence is strongly associated with an increased risk of severe skin reactions like SJS/TEN. If positive, alternative medications should be considered.
• Liver or Kidney Impairment: While not contraindicated, patients with significant liver or kidney disease or hypoalbuminemia may have altered phenytoin metabolism and protein binding, leading to higher unbound (active) drug levels. Close monitoring of drug levels (especially free phenytoin levels) is crucial. • Porphyria: Phenytoin can exacerbate acute intermittent porphyria, a rare genetic disorder affecting the nervous system and skin.
• Suicidal Thoughts or Behavior: Like other antiepileptic drugs, Dilantin can increase the risk of suicidal thoughts or behavior. Patients with a history of depression or suicidal ideation should be carefully monitored.

Drug Interactions:

Before taking Dilantin, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the official Dilantin website: https://www.dilantin.com/en.
• Medications that can DECREASE Dilantin Levels
o If your Dilantin levels drop, your seizures might not be as well controlled. Medications that can lower Dilantin include:
o Certain Antacids (like Maalox, TUMS). It's best to take Dilantin at least 2 hours before or after these.
o Certain Chemotherapy Drugs
o High Doses of Folic Acid
o Rifampin (for tuberculosis)
o Some Other Anti-Epileptic Drugs (like carbamazepine, vigabatrin)
o St. John's Wort (an herbal supplement) can significantly reduce Dilantin levels.
o Sucralfate (for ulcers)
o Theophylline (for breathing problems)

• Medications that can INCREASE Phenytoin Levels (leading to increased risk of phenytoin side effects/toxicity):
o Amiodarone (for heart rhythm problems)
o Certain Antidepressants (like Prozac, Zoloft, amitriptyline)
o Certain Antifungals (like fluconazole, ketoconazole)
o Disulfiram (for alcohol addiction)
o Methylphenidate (for ADHD)
o Other Seizure Medications (such as felbamate, oxcarbazepine, ethosuximide)
o Some Antibiotics (such as chloramphenicol, Bactrim, Cipro, clarithromycin)
o Stomach Acid Reducers (including common heartburn medications like Prilosec, Nexium, Tagamet HB)
o Valproic acid/Divalproex sodium (another seizure medication) can have unpredictable effects, sometimes increasing or decreasing Dilantin levels.

• Medications Whose Effectiveness Can Be Lowered by Dilantin
o Antifungals (like those mentioned above)
o Blood Thinners (like Warfarin, Eliquis, Pradaxa, Xarelto): Dilantin can make these less effective, increasing your risk of blood clots. Your doctor will need to monitor your blood closely if you take these together.
o Certain Anti-HIV Medications
o Certain Statins (for cholesterol, like Lipitor, Zocor)
o Corticosteroids (like prednisone)
o Digoxin (for heart conditions)
o Dilantin can speed up the way your body breaks down many other drugs, making them less effective. This is especially important for:
o Hormonal Contraceptives (Birth Control Pills): Dilantin can significantly reduce how well birth control pills work, which could lead to an unplanned pregnancy. You should discuss alternative or additional birth control methods with your doctor.
o Immunosuppressants (like cyclosporine, tacrolimus, for organ transplants)
o Some Antipsychotics (like quetiapine, lurasidone)

• Interactions with Alcohol and Other Substances
o Alcohol: Drinking alcohol while on Dilantin can have unpredictable effects on your Dilantin levels and can worsen side effects like dizziness and confusion.
o Certain Herbal Supplements: Besides St. John's Wort, others like ginkgo, glutamine, kava, valerian, and passionflower may interact with Dilantin, potentially affecting your seizure control or making you more drowsy.

Pregnancy and Breastfeeding:

If you're pregnant, planning a pregnancy, or breastfeeding, it's essential to talk with your doctor about using Dilantin (phenytoin). This is because there are potential risks to your baby. If you're pregnant, Dilantin is known to carry a risk of birth defects, including something called Fetal Hydantoin Syndrome, and it can also increase the risk of bleeding problems for your newborn. However, it's crucial to balance these concerns with the need to effectively control your seizures, as uncontrolled seizures also pose significant risks to both you and your baby. If you're breastfeeding, small amounts of Dilantin pass into breast milk. While some manufacturers advise caution, many healthcare providers may support breastfeeding if your baby is closely monitored for side effects like unusual sleepiness or feeding difficulties, carefully weighing the benefits of breastfeeding against the importance of your seizure control.

Use in Children:

Dilantin (phenytoin) is a medicine often used in children to help control and prevent certain types of seizures. This includes seizures that cause shaking of the whole body (called tonic-clonic seizures) and those that might make a child stare blankly or seem confused (called complex partial seizures). Doctors may also prescribe Dilantin after brain surgery to help prevent seizures. Your child's doctor will carefully determine the amount of Dilantin they need.

Frequently Asked Questions about Dilantin at CanadaPharmacyOnline.com:

Why is Dilantin more affordable in Canada than in the United States?

Prescription drug prices, including Dilantin, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs than the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on getting you the lowest prices on high-quality products.

Can I buy Dilantin over the counter from you?

No, Dilantin requires a prescription from your doctor. We are unable to sell this product without a valid prescription from your doctor.

Is there a limit on how many Dilantin tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Dilantin at one time, per your doctor's prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Dilantin?

Yes, there is a generic alternative for this product, called Phenytoin.

Is Dilantin a controlled substance?

This medication is not considered to be a controlled substance, although it does require a prescription. Dilantin is not a major drug of abuse; its use does not produce significant euphoria, even though it may be used to control certain types of pain. (source)

Blog Posts:

Generic Dilantin Availability

News Post:

Guide to Antiseizure Medications (article published on May 21, 2025)

Similar Drugs in the category of Antiepileptic Medication:

Lamictal Topamax Keppra Tegretol XR Depakote ER

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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