Divigel (Estradiol)

Name: Divigel
Brand: Searchlight Pharma
SKU: 6902
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Divigel 30 Single-Dose Gel Packets

Manufacturer: Searchlight Pharma

Country: Canada

Dosage: 0.25 mg

Qty-Price (USD):

Type:

Product: Divigel Gel Sachets

Manufacturer: Orion

Country: United Kingdom

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Divigel 30 Single-Dose Gel Packets

Manufacturer: Searchlight Pharma

Country: Canada

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Divigel Gel Sachets

Manufacturer: Orion

Country: United Kingdom

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Divigel 30 Single-Dose Gel Packets

Manufacturer: Searchlight Pharma

Country: Canada

Dosage: 1 mg

Qty-Price (USD):

Generic Equivalent of Divigel

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no generic product of Divigel.

Divigel Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on September 23, 2025.

Divigel at CanadaPharmacyOnline.com

Divigel is the brand name manufactured by Searchlight Pharma in Canada. It is also sold under different names or by different manufacturers. For example, in the United Kingdom, a very similar estradiol gel is sold under the brand name Sandrena, which is manufactured by Orion Corporation.

Generic estradiol is currently unavailable (at this pharmacy).

Dosage:

The brands Divigel and Sandrena are both estradiol gels, available in various strengths and packaging formats.
• Divigel (Canada): This product is available in three strengths: 0.25 mg, 0.5 mg, and 1 mg. Each box contains 30 single-dose gel packets.
• Sandrena (UK/Europe): This product is typically available in two strengths: 0.5 mg and 1 mg. Each box contains gel sachets, with the total number of sachets varying by country and package size.

Your doctor will determine the appropriate dosage based on your individual needs and medical conditions.

Usage:

Divigel is an estrogen replacement gel used to treat menopausal symptoms like hot flashes and vaginal dryness, burning, and irritation. It can also help prevent osteoporosis in high-risk postmenopausal women. The gel is applied once daily to the thigh, allowing the body to absorb estrogen through the skin and replenish its declining estrogen levels. For women who still have a uterus, a progestin is usually prescribed alongside Divigel to protect the uterine lining and lower the risk of overgrowth.

Mechanism of Action:
Divigel (estradiol) is a form of estrogen that delivers its main ingredient, estradiol, directly through the skin into your bloodstream. Once absorbed, it binds to specific estrogen receptors in various parts of the body, essentially mimicking the effects of your natural estrogen. This action helps to relieve menopausal symptoms and can also aid in preventing bone thinning (osteoporosis). Because it's applied to the skin, Divigel bypasses immediate liver processing, which can help maintain more consistent hormone levels in your system.

Take Divigel exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Divigel, it is essential to discuss all possible effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Divigel (estradiol). It is not an exhaustive list, and individual reactions can vary.

Common side effects: The following are some common side effects of Divigel; other side effects may also occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Breast pain or tenderness
• Headache
• Nausea
• Stomach pain
• Swelling in hands or feet
• Vaginal discharge or irritation
• Weight changes

Other Potential Side Effects (less common):
• Dizziness
• Mood changes
• Muscle or joint pain
• Rash
• Vomiting

Serious or rare side effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Blood clots in the legs or lungs
• Breast cancer
• Cardiovascular events (e.g., heart attack or stroke)
• Endometrial cancer (cancer of the uterine lining)
• Gallbladder disease
• High blood pressure
• Liver problems
• Ovarian cancer
• Vision changes

Contraindications:

This is not an exhaustive list of contraindications. Before taking Divigel, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor and pharmacist.

Divigel should not be used if you have any of the following conditions:
• Active or History of Blood Clots (Thromboembolic Disorders):
o Arterial Thromboembolic Disease (e.g., heart attack, stroke, angina)
o Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE)
o Known Thrombophilic Disorders (inherited or acquired disorders that increase blood clot risk)
• Known Hypersensitivity or Allergic Reaction: If you have a known allergy to estradiol or any of the inactive ingredients in Divigel.
• Known or Suspected Estrogen-Dependent Cancers:
o Breast Cancer
o Endometrial Cancer (Cancer of the Uterine Lining) or untreated endometrial hyperplasia
o Other Estrogen-Dependent Neoplasia
• Liver Dysfunction or Disease: If you have severe liver disease or your liver function tests have not returned to normal after a previous liver condition.
• Porphyria: A rare, inherited blood disorder.
• Undiagnosed Abnormal Genital Bleeding: Any unusual or unexplained vaginal bleeding that a doctor has not investigated.

Drug Interactions:

Before taking Divigel, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit Orion prescribing information | orion.fi: http://site9.orion.fi/contentassets/f10ba73a980348e78c1100c5bd5a2053/divigel-pi.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Divigel may interact with other medicines, including but not limited to:
• Anticoagulants (Blood Thinners) like warfarin: Estrogens can affect the activity of anticoagulants, such as Warfarin, potentially decreasing the blood-thinning effect and increasing the risk of blood clots. Close monitoring of blood clotting times (INR) is necessary.
• Anticonvulsants (e.g., Carbamazepine, Phenobarbital, Phenytoin): These medications can increase the activity of liver enzymes that break down estradiol, potentially reducing Divigel's effectiveness.
• Antidiabetic Medications: Estrogens can sometimes affect blood sugar control, potentially impacting the effectiveness of antidiabetic drugs. Diabetic patients may require closer monitoring of their blood sugar levels.
• Antifungal Medications (e.g., Itraconazole, Ketoconazole, Voriconazole): Some antifungals can slow down the breakdown of estradiol, potentially increasing its levels and the risk of side effects.
• Antituberculosis Drugs (e.g., Rifampin, Rifabutin): These antibiotics can speed up the breakdown of estradiol, potentially reducing Divigel's effectiveness.
• Aromatase Inhibitors (e.g., Anastrozole, Letrozole, Exemestane): These drugs are used to treat certain breast cancers by blocking estrogen production. Taking Divigel (estradiol) concurrently would counteract its therapeutic effect and is generally avoided.
• Corticosteroids: Estrogen may decrease how quickly corticosteroids are cleared from the body, potentially leading to increased effects or side effects of corticosteroids.
• Grapefruit Juice: Can slow down the breakdown of estradiol, potentially increasing its levels. It's often advised to avoid or limit grapefruit products while on estrogen therapy.
• Herbal Supplements (e.g., St. John's Wort): This supplement can speed up the breakdown of estradiol, potentially reducing Divigel's effectiveness.
• HIV Medications (e.g., Ritonavir-containing products, Nelfinavir): Some HIV medications can either speed up or slow down the breakdown of estradiol, or have complex interactions, potentially reducing Divigel's effectiveness or increasing side effects.
• Thyroid Hormones (e.g., Levothyroxine): Estrogen can increase the need for thyroid hormone, potentially requiring an increase in the dose of thyroid hormone replacement therapy in patients with hypothyroidism.

Pregnancy and Breastfeeding:

During pregnancy, Divigel is not indicated and should be stopped immediately if you become pregnant, as its safety for fetal development hasn't been established for this purpose. When breastfeeding, estradiol can pass into breast milk and may also reduce your milk supply. Suppose you are pregnant or breastfeeding, or planning to be. In that case, it is crucial to have a thorough discussion with your doctor, who will help determine the safest and most effective approach for managing your condition, taking into account all potential benefits and risks.

Use in Children:

Divigel, an estradiol gel, is not typically approved or recommended for use in children, as its primary purpose is hormone replacement therapy for menopausal symptoms in adult women.

Frequently Asked Questions about Divigel at Canada Pharmacy Online:

Why is Divigel more affordable in Canada than in the United States?

Prescription drug prices, including Divigel, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

Is there a limit on the number of Divigel packets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Divigel at one time, as per your doctor's prescription.

Can I buy Divigel over the counter from you?

No, Divigel requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Divigel?

No, there is currently no generic alternative available.

Blog Post:

Easy, Inexpensive Methods to Stave Off Menopause

News:

Why Genitourinary Syndrome of Menopause Is Often Missed (article published on September 17, 2025)

Similar Drugs in the category of Menopausal Hormone Therapy:

Estring Vaginal Ring Premarin Vagifem Vivelle Dot Premarin Vaginal Cream

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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