Vivelle Dot (Estradiol-17B)

Name: Vivelle Dot
Brand: Sandoz
SKU: 2513
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Vivelle Dot

Manufacturer: Sandoz

Country: Canada

Dosage: 25 mcg

Qty-Price (USD):

Type:

Product: Vivelle Dot

Manufacturer: Sandoz

Country: Canada

Dosage: 37.5 mcg

Qty-Price (USD):

Type:

Product: Vivelle Dot

Manufacturer: Sandoz

Country: Canada

Dosage: 50 mcg

Qty-Price (USD):

Type:

Product: Vivelle Dot

Manufacturer: Sandoz

Country: Canada

Dosage: 75 mcg

Qty-Price (USD):

Type:

Product: Vivelle Dot

Manufacturer: Sandoz

Country: Canada

Dosage: 100 mcg

Qty-Price (USD):

Generic Equivalent of Vivelle Dot

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Estradiol-17B

Manufacturer: Generic

Country: Canada

Dosage: 50 mcg

Qty-Price (USD):

Type:

Product: Estradiol-17B

Manufacturer: Generic

Country: Canada

Dosage: 75 mcg

Qty-Price (USD):

Type:

Product: Estradiol-17B

Manufacturer: Generic

Country: Canada

Dosage: 100 mcg

Qty-Price (USD):

Vivelle Dot Information

medically reviewed by Carol Hou (BSc. Pharm) on July 11, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Vivelle Dot and Estradiol-17β at CanadaPharmacyOnline.com

Vivelle Dot (estradiol-17β transdermal patch, primarily known in the US) has a widely available Canadian equivalent called Estradot. Estradot is manufactured by Novartis (Sandoz is a Novartis division) and is available in Canada.

Generic estradiol-17β is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Estradiol-17β:

Generic estradiol-17β contains the same active ingredient as the brand-name Vivelle Dot and is required to meet the same safety, effectiveness, and quality standards as the brand-name product. This means it is designed to work in the same way as Vivelle Dot. Studies have demonstrated bioequivalence between generic and brand-name estradiol-17β, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic estradiol-17β, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, please refer to Access to Generic Drugs in Canada | Canada.ca

Dosage:

Brand estradiol-17β transdermal patches, including Estradot, are available in strengths of 25 mcg, 37.5 mcg, 50 mcg, 75 mcg, and 100 mcg.

Generic estradiol-17β transdermal patches are available in 50 mcg, 75 mcg, and 100 mcg dosages.

Your doctor will determine the appropriate dosage based on the individual needs and medical conditions.

Usage:

Vivelle Dot (estradiol-17β) is a prescription patch used as a hormone therapy in postmenopausal women. The drug helps to treat moderate to severe vasomotor symptoms like hot flashes and night sweats associated with menopause. Vivelle Dot also helps prevent postmenopausal osteoporosis and treats mild to severe symptoms of vulvar and vaginal atrophy due to menopause, such as vaginal dryness, itching, burning, and painful intercourse.

Mechanism of Action:
Vivelle Dot (estradiol-17β) is a type of estrogen, a female hormone. It slowly releases a small amount of estradiol through the skin into the blood. This helps replace the estrogen your body has lost during menopause, which can ease symptoms like hot flashes and also help keep your bones strong.

Use Vivelle Dot exactly as your doctor prescribes. Do not change your dosage or stop using the medication without consulting your doctor. Follow the instructions in the product monograph in Canada: https://pdf.hres.ca/dpd_pm/00077221.PDF. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before using Vivelle Dot, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Vivelle Dot, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects – These are examples of some common side effects of Vivelle Dot, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning or if you experience any other concerning symptoms.
• Bloating
• Breast pain
• Edema
• Headache
• Nausea
• Redness or irritation at the application site

Serious or rare side effects – Stop using Vivelle Dot and seek immediate medical attention right away if you experience any of the following:
• Allergic reactions, including angioedema, hives, and trouble breathing
• Breast lumps
• Heart attack, including chest pain or pressure, pain spreading to your jaw or shoulder
• Stroke, including sudden numbness or weakness, especially on one side of the body
• Unusual vaginal bleeding

Contraindications:

This is not an exhaustive list of contraindications. Before starting Vivelle Dot, it is crucial to discuss all your medical conditions, past and present, and all medications you are using with your doctor or pharmacist.

Estradiol-17β transdermal patches (such as Estradot or generic equivalents) should not be used if you have:
• An allergy to estradiol-17β or any of the patch's inactive ingredients.
• A history of cancer of the breast, uterus, or endometrium.
• A history of heart attack, stroke, or coronary heart disease.
• A history of migraines with aura, as this increases the risk of stroke.
• Abnormal and undiagnosed vaginal bleeding.
• Active deep vein thrombosis (DVT) or pulmonary embolism (PE).
• Active thrombophlebitis (inflammation of a vein with a blood clot).
• Porphyria.
• Severe liver disease.

Tell your doctor about all of your medical conditions, past and present, before starting Vivelle Dot. This is crucial because certain conditions can affect whether Vivelle Dot is right for you. These conditions may include, but are not limited to:
• Asthma
• Diabetes
• Family history of blood clots, heart disease, or stroke
• Gall bladder disease
• Hereditary or acquired angioedema
• High blood pressure
• History of breast disease
• History of depression
• History of epilepsy
• Hypothyroidism
• Hysterectomy
• Kidney problems
• Liver disease
• Lupus
• Several miscarriages
• Uterine fibroids or endometriosis

Alcohol:
It is generally advisable to limit or avoid alcohol consumption while using estradiol-17β transdermal patches (such as Estradot or generic equivalents). While alcohol's direct interaction with transdermal patches is usually less significant than with oral medications, alcohol itself can sometimes worsen menopausal symptoms (like hot flashes) and has its own general health risks. Always discuss your alcohol intake with your doctor or pharmacist for personalized advice on safe use.

Cancer Risk:
Using estradiol alone can increase the risk of cancer of the uterine lining (endometrial cancer) in women who still have a uterus. To lower this risk, women with a uterus are usually given progestin along with estrogen.

Using estradiol with progestin has also been linked to a higher risk of invasive breast cancer. It's essential for all women on hormone therapy to have regular breast checkups and do monthly self-exams.

Some studies suggest that estradiol-only therapy may slightly raise the risk of ovarian cancer.

Cardiovascular Disorders:
Taking estrogen by itself can raise the risk of serious health problems like stroke, blood clots in the legs (DVT), blood clots in the lungs (PE), and heart attacks in women after menopause. If you already have heart or circulation problems, it's essential to discuss these risks with your doctor before starting or continuing Vivelle Dot.

Dementia:
There is an increased risk of dementia in postmenopausal women who are 65 years and older.

Dizziness and Impaired Driving Risk
Vivelle Dot can cause blurred vision, dizziness, drowsiness, or tiredness. These effects may impair your concentration and reaction time. Do not drive, operate heavy machinery, or engage in tasks requiring full alertness until you can do so safely and know how Vivelle Dot affects you. If you have concerns, speak with your doctor or pharmacist.

Grapefruit:
Avoid consuming grapefruit products while using Vivelle Dot. Grapefruit can increase the risk of side effects of this medication.

Drug Interactions:

Before using Vivelle Dot, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete information about possible drug interactions, please consult the full prescribing information at https://www.novartis.com/us-en/sites/novartis_us/files/Vivelle_DOT.pdf and discuss any concerns with your healthcare provider.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Vivelle Dot can interact with other medicines but is not limited to;
• CYP3A4 inducers (e.g., phenobarbital, carbamazepine, rifampin, St. John’s wort): These can decrease estrogen plasma concentrations, potentially reducing the therapeutic effects of Vivelle Dot
• CYP3A4 inhibitors (e.g., erythromycin, ketoconazole, ritonavir): These can potentially increase estrogen levels in the body

Pregnancy and Breastfeeding:

If you are pregnant or become pregnant, tell your doctor before using Vivelle Dot. Vivelle Dot is for use in postmenopausal women. Estradiol-17β may affect an unborn baby. It is essential to discuss the risks and benefits of using Vivelle Dot with your doctor before starting treatment. If you are breastfeeding or plan to breastfeed, inform your doctor. Estradiol-17β is excreted in human breast milk and may reduce the quantity and quality of breast milk. Discuss the risks and benefits of using Vivelle Dot with your doctor before using it.

Frequently Asked Questions about Vivelle Dot at Canada Pharmacy Online

Why is Vivelle Dot more affordable in Canada than in the United States?

Prescription drug prices, including Vivelle Dot, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs than the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on getting you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about the ordering process, please visit our How to Order page.

Is there a limit on how many Vivelle Dot patches I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Vivelle Dot at once, per your doctor's prescription.

Can I buy Vivelle Dot over the counter from you?

No, Vivelle Dot requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the difference between Vivelle Dot 75 mcg and 100 mcg?

The difference in dosage represents the amount of the drug's active ingredient(s) (estradiol-17β).

How should I use Vivelle Dot?

Use Vivelle Dot exactly as prescribed by your doctor. Apply the patch to a clean, dry area on your lower abdomen only. Ensure the area is clean, dry, and free of powder, oil, or lotion. Apply the Vivelle Dot patch to a different area of your abdomen each time you use it. Do not use the same application site 2 times in the same week.

How often do I change the Vivelle-Dot patch?

Vivelle-Dot patches should be applied twice weekly, every 3 to 4 days.

How should I dispose of used patches?

Fold the sticky sides of the used patch together and dispose of it in a way that prevents children and pets from reaching it. You can dispose of it in a covered trash can. Do not flush down the toilet.

Can I swim or shower with the patch on?

The patch can stay on during showering, bathing, and swimming.

Blog Posts:

Menopause: Separating Fact from Fiction on the Trendiest Topic of the Year
Easy, Inexpensive Methods to Stave Off Menopause

Latest News:

Estrogen-only hormone therapy lowers young-onset breast cancer risk (article published on July 8, 2025)

Similar Drugs in the category of Menopausal Hormone Therapy:

Estring Vaginal Ring Premarin Vagifem Premarin Vaginal Cream CombiPatch

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

Reviews From Real Customers