Premarin (Conjugated Estrogens)

Name: Premarin
Brand: Pfizer
SKU: 1875
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Premarin

Manufacturer: Pfizer

Country: Canada

Dosage: 0.3 mg

Qty-Price (USD):

Type:

Product: Premarin

Manufacturer: Pfizer

Country: Canada

Dosage: 0.625 mg

Qty-Price (USD):

Type:

Product: Premarin

Manufacturer: Pfizer

Country: India

Dosage: 0.625 mg

Qty-Price (USD):

Type:

Product: Premarin

Manufacturer: Pfizer

Country: Australia

Dosage: 0.625 mg

Qty-Price (USD):

Type:

Product: Premarin

Manufacturer: Pfizer

Country: Canada

Dosage: 1.25 mg

Qty-Price (USD):

Type:

Product: Premarin

Manufacturer: Pfizer

Country: United Kingdom

Dosage: 1.25 mg

Qty-Price (USD):

Generic Equivalent of Premarin

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Conjugated Estrogens

Manufacturer: Generic

Country: United Kingdom

Dosage: 0.3 mg

Qty-Price (USD):

Type:

Product: Conjugated Estrogens (ON BACKORDER)

Manufacturer: Generic

Country: United Kingdom

Dosage: 0.625 mg

Qty-Price (USD):

Type:

Product: Conjugated Estrogens

Manufacturer: Generic

Country: United Kingdom

Dosage: 1.25 mg

Qty-Price (USD):

Premarin Information

medically reviewed by Carol Hou (BSc. Pharm) on October 9, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Premarin and Conjugated Estrogens at CanadaPharmacyOnline.com

The brand Premarin, manufactured by Pfizer, is available in many countries globally, including Canada, Australia, India, and the United Kingdom.

Generic conjugated estrogens are sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Conjugated Estrogens:

Generic conjugated estrogens contain the same active ingredient as brand-name Premarin and are required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Premarin. Studies have shown that generic conjugated estrogens are bioequivalent to brand-name Premarin, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, Individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs.

Dosage:

At this pharmacy, the brand Premarin and its generic equivalent are commonly available in a wider range of oral tablet strengths, including 0.3 mg, 0.625 mg, and 1.25 mg. Premarin is also available as a vaginal cream.

Your conditions will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Premarin (Conjugated Estrogens) is a mixture of estrogens, primarily in the form of water-soluble sulfate esters, derived from the urine of pregnant mares, used for Menopausal Hormone Therapy (MHT). It may also help prevent osteoporosis in postmenopausal women and replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen. Additionally, it can help alleviate symptoms such as hot flashes. Premarin is sometimes used as part of cancer treatment in both women and men.

Mechanism of Action:
Premarin (conjugated estrogens) works by replacing the estrogen that a woman's body naturally produces less of after menopause. Once taken, the medication's components activate within the body, traveling to various tissues and binding to specific estrogen receptors in cells. By activating these receptors, Premarin effectively restores the estrogen signals needed to support many bodily functions. This action helps regulate the body's temperature control center (hypothalamic thermoregulation) to reduce hot flashes, supports the health and elasticity of vaginal tissues to relieve dryness and painful intercourse, and inhibits bone resorption (the breakdown of bone) by suppressing the activity of osteoclasts (the cells that resorb bone).

Take Premarin exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Premarin, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Premarin (conjugated estrogens). It is not an exhaustive list, and individual reactions can vary.

Common side effects – The following are some common side effects of Primarin; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal cramps/bloating
• Back pain
• Breast pain or tenderness
• Flatulence (gas)
• Headache
• Nausea and vomiting
• Vaginal discharge (increased or irregular bleeding/spotting)
• Vaginitis or irritation (including vaginal yeast infection)

Other Potential Side Effects (less common):
• Depression
• Enlargement of benign tumors of the uterus (fibroids)
• Fluid retention (edema)
• Gallbladder disease
• Hair loss
• Insomnia (trouble sleeping)
• Pain in the pelvis or legs

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any signs, such as:
• Dementia: Increased risk, especially in women 65 years of age or older.
• Liver Problems: Including liver impairment or cholestatic jaundice.
• Severe Allergic Reaction (Anaphylaxis): Which can include swelling of the face, lips, tongue, or throat, or trouble breathing.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Premarin, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or Pharmacist.

Premarin should not be used if you have any of the following conditions:
• An active or history of arterial thromboembolic disease (e.g., myocardial infarction or stroke).
• An active or history of venous thromboembolism (e.g., pulmonary embolism or deep vein thrombosis).
• A known anaphylactic reaction or angioedema to Premarin.
• A known or suspected estrogen-dependent neoplasia.
• A known or suspected pregnancy.
• A known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders.
• A liver dysfunction or disease.
• An undiagnosed abnormal genital bleeding.
• Breast cancer or a history of breast cancer
• Untreated endometrial hyperplasia

Tell your doctor about your medical conditions, past and present, before starting Premarin. This is crucial because certain conditions can affect whether Premarin is right for you. These conditions may include, but are not limited to:
• Asthma
• Diabetes mellitus
• Endometriosis
• Epilepsy
• Fluid retention
• Gallbladder disease
• High blood pressure (hypertension)
• High blood fats (hypertriglyceridemia)
• History of cholestatic jaundice
• Hypocalcemia
• Hypothyroidism
• Leiomyoma (uterine fibroids)
• Migraine (especially with aura)
• Otosclerosis
• Systemic lupus erythematosus (SLE)

Drug Interactions:

Before taking Premarin, it is essential to discuss all potential risks and interactions with your healthcare provider, such as your doctor or pharmacist. For complete and up-to-date information, please visit the Premarin prescribing information | Pfizer at https://labeling.pfizer.com/ShowLabeling.aspx?id=15019.

Provide your doctor with a complete list of all your medications, including over-the-counter (OTC) drugs, vitamins, and herbal supplements. Premarin may interact with other medicines, but is not limited to:
• Anticoagulants: Conjugated estrogens may antagonize the effect of anticoagulants (e.g., warfarin) by affecting clotting factors, which can increase the risk of blood clots and may require dosage adjustment and closer monitoring.
• Antidiabetic Medications: Premarin may decrease the therapeutic efficacy of antidiabetic medications (e.g., Acarbose).
• Corticosteroids (e.g., Dexamethasone, Prednisolone): Estrogens may increase the effects of corticosteroids.
• Levothyroxine (Thyroid Hormones): Estrogen use may change the amount of thyroid replacement therapy (e.g., Levothyroxine) needed, requiring careful monitoring.
• Theophylline: Estrogens may increase the effects of Theophylline (a drug for asthma/COPD), potentially leading to toxicity.
These interactions can decrease Premarin levels:
• Anti-epileptics/Anticonvulsants:
o Carbamazepine
o Phenobarbital
o Phenytoin
• Antibiotics/Antituberculosis Drugs:
o Rifampin
• Herbal Supplements:
o St. John's Wort (Hypericum perforatum)
These interactions can increase Premarin levels:
• Azole Antifungals:
o Itraconazole
o Ketoconazole
• Food/Beverages:
o Grapefruit juice
• Macrolide Antibiotics:
o Clarithromycin
o Erythromycin
• Other Medications:
o Cimetidine
o Ritonavir (an antiviral)

Pregnancy and Breastfeeding:

If you are pregnant or think you might be, you should never take Premarin (conjugated estrogens), as it can pose a risk to the baby. Due to similar safety concerns and the fact that hormones can pass into the infant's system, potentially reducing your milk supply, Premarin is also not recommended while breastfeeding. Always make sure your healthcare provider knows about your pregnancy or breastfeeding status so they can recommend the safest treatment options for you.

Use in Children:

Premarin (conjugated estrogens) is not a standard treatment, and its safety and effectiveness are not fully established for general use in children. However, a healthcare provider may prescribe it in specific cases, such as to help induce puberty in adolescents with delayed development or to manage conditions where the body isn't producing enough estrogen naturally (like hypogonadism). It is also sometimes used as a topical cream for a short period to treat a condition called labial adhesions in young girls. Because high or prolonged doses of estrogen can potentially affect a child's final height by prematurely closing growth plates and can cause early development signs like breast growth or vaginal bleeding, treatment with Premarin must be approached with extreme caution and under careful, regular supervision by a doctor.

Use in Older Adults:

The use of oral Premarin (conjugated estrogens) in older postmenopausal women, especially those starting treatment years after menopause (typically over age 60 or more than 10 years post-menopause), is generally not recommended for the prevention of chronic conditions.

Frequently Asked Questions about Premarin at Canada Pharmacy Online:

Why is Premarin more affordable in Canada than in the United States?

Prescription drug prices, including Premarin, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784 for more information or to learn about the ordering process. Visit our How to Order page for details.

Can I buy Premarin over the counter from you?

No, Premarin requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

What is the difference between Premarin 0.625 mg and 0.3 mg?

The difference in dosage represents the amount of active ingredient(s) present in the drug.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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