Megace (Megestrol Acetate)

Name: Megace
Brand: Generic
SKU: 1674
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no brand product of Megace.

Generic Equivalent of Megace

Type

Product

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Qty-Price (USD)

Type:

Product: Megestrol Acetate

Manufacturer: Generic

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Megestrol Acetate

Manufacturer: Generic

Country: Canada

Dosage: 160 mg

Qty-Price (USD):

Type:

Product: Megestrol Acetate

Manufacturer: Generic

Country: India

Dosage: 160 mg

Qty-Price (USD):

Type:

Product: Megestrol Acetate

Manufacturer: Generic

Country: India

Dosage: 160 mg

Qty-Price (USD):

Type:

Product: Megestrol Acetate

Manufacturer: Generic

Country: New Zealand

Dosage: 160 mg

Qty-Price (USD):

Megace Information

Megestrol Acetate at CanadaPharmacyOnline.com

The manufacturer of brand-name Megace (megestrol acetate) is Bristol-Myers Squibb (Canada). The brand Megace is currently unavailable (at this pharmacy).

The generic megestrol acetate is produced by several reputable manufacturers that meet the strict standards of Health Canada. The specific manufacturer of the medication dispensed may vary based on pharmacy inventory. Generic megestrol acetate is sourced from manufacturers that meet applicable regulatory standards.

Important Information about Generic Megestrol Acetate

Generic megestrol acetate contains the same active ingredient as brand-name Megace. It must meet the same effectiveness and quality standards. This means it is designed to work like Megace. Studies have shown that generic megestrol acetate is bioequivalent to brand-name Megace, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Megestrol acetate is available in the following oral strengths at this pharmacy:
• Tablets: 40 mg and 160 mg oral tablets

Dosage is individualized and based on tolerability. Breast cancer typically requires 40 mg four times daily (160 mg/day), endometrial cancer requires 40 to 320 mg/day, and cachexia uses much higher doses (400 to 800 mg/day). Do not stop using this medication without talking to your oncologist.

Usage:

Megace (megestrol acetate) is a synthetic progestogen indicated for the palliative treatment of recurrent, inoperable, or metastatic breast cancer and endometrial (uterine) cancer, and for the treatment of anorexia, cachexia, and unexplained significant weight loss in patients with AIDS or cancer. In cancer patients and those with AIDS, loss of appetite and weight (cachexia) can be a debilitating complication of the disease. Megace helps stimulate appetite and promotes weight gain through its progestational and mild glucocorticoid-like effects.

Mechanism of Action
Megestrol acetate is a synthetic progestogen (progestin) derived from progesterone. In breast and endometrial cancer, it works by competitively binding to progesterone receptors (and, to a lesser extent, estrogen receptors), exerting antiproliferative effects on cancer cells that depend on these hormonal signals. In cancer cachexia, megestrol acetate stimulates appetite through a mechanism not fully understood but thought to involve inhibition of pro-inflammatory cytokines (such as interleukin-1 and tumor necrosis factor) that drive cancer-related weight loss, as well as direct effects on hypothalamic appetite centers. The mild glucocorticoid-like activity of megestrol at high doses may also contribute to its appetite-stimulating effects.

Take Megace exactly as your doctor prescribes, according to the Product Monograph. Take with or without food.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Megace, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Megace (megestrol acetate). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Megace; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Fluid retention or ankle swelling
• High blood pressure
• Hot flushes or vaginal bleeding (in women)
• Increased appetite and weight gain (an intended effect for cachexia patients)
• Mood changes
• Impotence or decreased libido (in male patients)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Adrenal Insufficiency: If Megace is stopped suddenly, adrenal insufficiency may develop (severe fatigue, nausea, low blood pressure, confusion). Do not stop high-dose Megace suddenly without medical guidance.
• Blood Clots (Thromboembolic Events): Leg pain, swelling, warmth, or redness (deep vein thrombosis); chest pain or shortness of breath (pulmonary embolism). Seek emergency care immediately.
• High Blood Sugar (Hyperglycemia) and New-Onset Diabetes: Increased thirst or urination, blurred vision.
• Severe Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.

Contraindications:

Do not take Megace/megestrol acetate if:
• Allergies: Known hypersensitivity to megestrol acetate or any ingredient in the formulation.
• Pregnancy: Megace is strictly contraindicated if you are pregnant or may become pregnant.

Tell your doctor about all of your medical conditions, past and present, before starting Megace. This is crucial as certain conditions affect the drug's safety.
• A history of blood clots
• Cardiovascular disease
• Diabetes
• High blood pressure
• Liver disease

Drug Interactions:

Before taking Megace, discuss all potential risks and interactions with your doctor or pharmacist. For complete information, please refer to the Product Monograph.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Megace. Megace may interact with other medicines, including but not limited to:
• Anticoagulants (warfarin): Megestrol may alter coagulation and affect warfarin efficacy. Monitor INR.
• Antidiabetic agents: High-dose megestrol can raise blood glucose and may reduce the effectiveness of insulin and oral hypoglycemic agents. Monitor blood glucose closely.
• Indinavir (and other HIV antiretrovirals): Megestrol can significantly decrease indinavir concentrations in the body (reducing its overall absorption by roughly 21% to 32%). This can decrease the effectiveness of your HIV therapy, and your doctor may need to increase your indinavir dose.

Pregnancy and Breastfeeding:

Inform your doctor if you are pregnant or planning to become pregnant. Megace is contraindicated during pregnancy. Progestogens can cause virilization (male hormone effects) in a female fetus. Women who may be pregnant should not take Megace. It is not known whether megestrol passes into breast milk in significant quantities. Consult your doctor to weigh the benefits and risks of this medicine before using it while nursing. Breastfeeding is not recommended while taking Megace. Discuss the risks and benefits with your doctor.

Use in Children:

The safety and efficacy of Megace in children have not been established for the cancer indications. Megace is not recommended for use in children.

Frequently Asked Questions about Megace at Canada Pharmacy Online

Why is Megace more affordable in Canada than in the United States?

Prescription drug prices, including Megace, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Megace I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Megace per your doctor's prescription.

Can I buy Megace from you over the counter?

No, Megace requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Megace?

Yes, the generic alternative, megestrol acetate, is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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