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Activella (Estradiol/Norethindrone Acetate)

Qty-Price (USD)
Type: drug type
Product: Activella LD Tablets
Manufacturer: Novo Nordisk
Country: Canada
Dosage: 0.5 mg/0.1 mg
Type: drug type
Product: Activella Tablets
Manufacturer: Novo Nordisk
Country: Canada
Dosage: 1 mg/0.5 mg
Type: drug type
Product: Activella Tablets (ON BACKORDER)
Manufacturer: Novo Nordisk
Country: Turkey
Dosage: 1 mg/0.5 mg

Generic Equivalent of Activella
Qty-Price (USD)
There is no generic product of Activella.

Activella Information

reviewed by Dr. HaVy Ngo, Pharmacist on 3/22/2023 12:11:27 PM.

Activella Details (Brand and Generic) currently offers the brand name Activella also called Activelle from Canada and Turkey manufactured by Novo Nordisk. There is no generic available for this medication.


Activella is available in the strength of 0.5 mg/0.1 mg LD tablets and 1 mg/0.5 mg tablets.


Activella (Estradiol/Norethindrone Acetate) is a combination medication that is used to help reduce symptoms of menopause such as hot flashes and vaginal dryness. This medication contains two female hormones, estrogen and progesterone. The progestin in this medication helps to reduce the risk of cancer of the uterus that can be caused by using estrogen. Women who have had their uterus removed do not need the progestin and they should not use this medication. Activella may also be used by women after menopause to prevent osteoporosis.

Side Effects and Precautions

Stop using the medication and get medical care if you have an allergic reaction. Signs of an allergic reaction may include difficulty breathing, hives (rash on your body), swelling of your face, lips, tongue, or throat—If you experience any of these symptoms, please call 911 or seek emergency medical care at the nearest emergency room (ER).

The common side effects of Activella includes breast pain, changes in menstrual periods, fluid retention, headache, nausea, thinning scalp hair, vaginal itching or discharge, and vomiting.

Call your doctor right away if you have any of the serious side effects such as:
• A lump in your breast;
• High levels of calcium in your blood (nausea, vomiting, constipation, etc);
• Jaundice;
• Problems with memory (confusion, unusual behavior);
Signs of stroke;
• Signs of blood clot;
• Swelling or tenderness in your stomach;
• Symptoms of a heart attack;
• Unusual vaginal bleeding

The above information is a summary and may not contain all information. If you still have questions about side effects, you should talk to your doctor or pharmacist so they can address all your concerns.

Warnings and Interactions

You should not use Activella if are allergic to Estradiol or Norethindrone. You should not use this medication if have had a hysterectomy or are pregnant, or if you will have major surgery. Activella is not indicated for those who have:
• A blood clot;
• A bleeding disorder;
• A history of heart attack or stroke;
• Cancer (breast, cervix or vagina);
• Liver disease;
• Undiagnosed vaginal bleeding

Before you start taking this medication, talk to your doctor about your medical history especially if you have ever had:
• A thyroid disorder;
• Asthma;
• Endometriosis;
• Epilepsy or other seizure disorder;
• Gallbladder disease;
• Heart disease;
• Hereditary angioedema;
• High levels of calcium in your blood;
• Kidney disease;
• Liver problems or jaundice caused by pregnancy;
• Lupus;
• Migraines;

This medication may increase your risk of cancers of the breast, uterus, or ovaries. Activella should not be used to prevent heart disease, stroke, or dementia. Avoid smoking while you are using Activella as it can increase your risk of blood clots, stroke, or a heart attack. You should also avoid all grapefruit products. Tell your doctor about all the medications you take including prescription, OTC, and herbal medications and all the vitamins and supplements you take. There may be a drug interaction between Activella and other medications. Consult your doctor if you are pregnant, become pregnant or breast-feeding.

Why is Activella more affordable from Canada than the United States?

In general, all drug prices, not only Activella, are more affordable to order from Canada because the price of both the brand and generic medication is regulated by the government. Also, since we established in 2006, our vision is to provide safe and affordable medication to people in the US.

Is it safe to buy Activella from your pharmacy?

Our products are sourced only from facilities certified by authorities in the countries we import them from. has a rigorous process for selecting our partners, so that you, our customer, get the safest medicine. We are also a Certified Canadian Pharmacy that adheres to the requirements imposed by the Province of British Columbia.

What is the lowest price of Activella per unit?

The Activella 1 mg/0.5 mg starts at $1.51 per tablet and the 0.5 mg/0.1 mg starts at $3.36 per LD tablet.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on getting you the lowest prices on high quality products.

How do I order from your pharmacy?

Ordering Activella from us is very simple. You can place the order online or call Customer Service at 1866.920.3784. For additional information or for the ordering process, visit our How to Order page.

Are your Activella prices competitive?

Yes, we are taking great pride in offering some of the most competitive prices across Canadian pharmacies. In some cases, we might be able to either match or beat our competitors' prices. Please call our friendly customer service at 1866.920.3784.

Is there a limit on how many Activella tablets I am allowed to order at one time? can only dispense a maximum of a three month supply of Activella at one time, as per your doctor's prescription.

Can I buy Activella over the counter from you?

No, Activella requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Activella?

No, there is no generic alternative for this product.

Reference Links

Activella: Indications, Side Effects, Warnings -
DailyMed - ACTIVELLA- estradiol and norethindrone acetate

Similar Drugs in the category of Menopausal Hormone Therapy:

   Estring Vaginal Ring    Premarin    Vagifem    Vivelle Dot    Premarin Vaginal Cream

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions. Prices listed are in US dollars.

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Prescriptions Dispensed from Canada are Dispensed by Candrug Pharmacy #18985. 202A 8322-130th Street, Surrey, British Columbia, Canada V3W 8J9, 604-543-8711. Pharmacy Manager: Carol Hou.
This pharmacy is duly licensed in the province of British Columbia, Canada by the College of Pharmacists of BC. If you have any questions or concerns you can contact the college at: 200-1765 West 8th Ave Vancouver, BC V6J 5C6 Canada.
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