Afinitor (Everolimus)

Name: Afinitor
Brand: Novartis
SKU: 6664
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Afinitor Disperz Tablet

Manufacturer: Novartis

Country: Canada

Dosage: 2 mg

Qty-Price (USD):

Type:

Product: Afinitor Tablet

Manufacturer: Novartis

Country: New Zealand

Dosage: 2.5 mg

Qty-Price (USD):

Type:

Product: Afinitor Tablet

Manufacturer: Novartis

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Afinitor Tablet

Manufacturer: Novartis

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Generic Equivalent of Afinitor

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Everolimus Tablet

Manufacturer: Generic

Country: Canada

Dosage: 2.5 mg

Qty-Price (USD):

Type:

Product: Everolimus Tablet

Manufacturer: Generic

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Everolimus Tablet

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Afinitor Information

Afinitor and Everolimus at CanadaPharmacyOnline.com

The manufacturer of brand-name Afinitor (everolimus) is Novartis Pharmaceuticals. It is available in many countries worldwide, including Canada and Turkey.

Generic everolimus is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards. Generic everolimus is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Everolimus

Generic everolimus contains the same active ingredient as brand-name Afinitor. It must meet the same effectiveness and quality standards. This means it is designed to work like Afinitor. Studies have shown that generic everolimus is bioequivalent to brand-name Afinitor, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Afinitor (everolimus) is available in the following oral strengths at this pharmacy:
• Tablets: 2 mg, 2.5 mg, 5 mg, and 10 mg.

Dosage is individualized and based on tolerability.

Usage:

Afinitor (everolimus) is approved for the treatment of several advanced cancers, including advanced hormone receptor-positive, HER2-negative breast cancer (in combination with exemestane), advanced neuroendocrine tumors of pancreatic, gastrointestinal, or lung origin, advanced renal cell carcinoma (kidney cancer) after prior VEGF-targeted therapy, and subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex.

Mechanism of Action
Everolimus, the active ingredient in Afinitor, binds to and inhibits mTOR (mammalian target of rapamycin), a key regulator of cell growth, proliferation, and survival. In many cancers, the mTOR pathway is overactivated, driving tumor growth. By blocking mTOR, everolimus reduces the production of proteins that cancer cells need to grow and divide. Also, it reduces the formation of new blood vessels that feed tumors (anti-angiogenesis). Everolimus also has immunosuppressive properties, which is why it is used in organ transplantation (though Afinitor is specifically the anti-cancer formulation).

Take Afinitor exactly as your doctor prescribes, as outlined in the Product Monograph. Take Afinitor once daily at the same time each day, consistently, with or without food.

Swallow tablets whole with a glass of water. Do not crush or chew. If you are prescribed Afinitor Disperz, the tablets must be completely dissolved in water to prepare an oral suspension immediately before consumption, following the precise preparation instructions provided by your clinical team.

If a dose is missed by more than 6 hours, skip it and take the next scheduled dose. Close monitoring of blood counts, kidney function, and blood glucose is required during treatment. Do not stop or change your dose without consulting your oncologist.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Afinitor, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Afinitor (everolimus). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Afinitor; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Decreased appetite
• Fatigue or weakness
• Infections (including upper respiratory tract infections) — Afinitor suppresses the immune system.
• Mouth sores or oral ulcers (stomatitis)
• Nausea, diarrhea, or stomach upset.
• Skin rash or dry skin
• Swelling of the hands, feet, or ankles

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• High Blood Sugar (Hyperglycemia) and Diabetes: Increased thirst, frequent urination, or elevated blood glucose on testing. Afinitor inhibits insulin signaling pathways.
• Impaired Wound Healing: Pain, drainage, or opening of surgical or minor wound sites. Everolimus disrupts normal tissue remodeling. Do not use this medicine for at least 1 week before elective surgery, and keep it on hold for at least 2 weeks after major surgery until wounds are completely healed.
• Kidney Failure: Decreased urine output, significant swelling, or rapid weight gain.
• Mouth Sores (Severe Stomatitis): Severe pain or bleeding from mouth ulcers that interfere with eating. Special mouthwashes (non-alcoholic) are often prescribed to prevent or manage stomatitis.
• Non-Infectious Pneumonitis (Lung Inflammation): Shortness of breath, new or worsening cough, chest pain, or fever. This is one of the most serious side effects of Afinitor. Contact your oncologist immediately if you develop breathing difficulties.
• Severe Allergic Reaction (Hypersensitivity): Hives, swelling of the face, lips, tongue, or throat, difficulty breathing, or chest tightness.
• Severe Infections: Fever, chills, unusual fatigue, or signs of infection. Afinitor suppresses the immune system, increasing the risk of serious bacterial, fungal, or viral infections, including reactivation of dormant infections such as hepatitis B or tuberculosis.

Contraindications:

The following is not an exhaustive list of contraindications. Do not take Afinitor if you have a known hypersensitivity or severe allergic history to everolimus, sirolimus, temsirolimus, or any ingredients in the formulation.

Before starting Afinitor, it is crucial to discuss all your medical conditions, past and present, with your doctor or pharmacist, especially if you have:
• Diabetes
• Active infections
• High blood lipids
• Liver disease
• Upcoming surgeries
• Vaccinations (live vaccines must be avoided during treatment).

Drug Interactions:

Before taking Afinitor, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information at https://www.novartis.com/us-en/sites/novartis_us/files/afinitor.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Afinitor. Afinitor may interact with other medicines, including but not limited to:
• ACE inhibitors (e.g., lisinopril, ramipril): Increased risk of angioedema (severe swelling of the face, lips, tongue, or airways, which can be life-threatening) when combined with everolimus. Patients should monitor for immediate respiratory distress and facial swelling.
• CYP3A4 and P-glycoprotein inducers (e.g., rifampicin, phenytoin, carbamazepine, St. John's Wort): Significantly lower everolimus levels, reducing effectiveness.
• CYP3A4 and P-glycoprotein inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir) significantly raise everolimus blood levels, increasing the risk of toxicity. Avoid grapefruit, grapefruit juice, and starfruit during treatment.
• Live vaccines must be avoided during Afinitor treatment and for at least 3 to 6 months afterward due to prolonged immunosuppression. • Other immunosuppressants: Additive immunosuppression; increased infection risk.

Pregnancy and Breastfeeding:

Afinitor can cause harm to an unborn baby. Women of childbearing potential must use highly effective contraception during treatment and for 8 weeks after the final dose. Afinitor must not be used during pregnancy. Men taking Afinitor should also use contraception and not father a child during treatment and for 4 weeks after the final dose.

It is not known whether everolimus passes into breast milk. Breastfeeding must not be initiated or must be discontinued while taking Afinitor. Do not breastfeed for 2 weeks after your last dose of standard tablets, and extend this window to 4 weeks if you are taking Afinitor Disperz.

Caregivers who are pregnant or trying to become pregnant should avoid direct contact with crushed or broken Afinitor tablets or slurry due to potential risk to the fetus.

Use in Children:

Afinitor is approved for use in pediatric patients (1 year and older) for subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex. For other cancer indications in children, its safety and efficacy have not been established. Dosing in children is guided by body surface area and is determined by a specialist.

Frequently Asked Questions about Afinitor at Canada Pharmacy Online

Why is Afinitor more affordable in Canada than in the United States?

Prescription drug prices, including Afinitor, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Afinitor I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Afinitor per your doctor's prescription.

Can I buy Afinitor from you over the counter?

No, Afinitor requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Afinitor?

Yes, the generic everolimus is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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