Anzupgo (Delgocitinib)

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Anzupgo Cream

Manufacturer: Leo

Country: Canada

Dosage: 2 %/60 gm

Qty-Price (USD):

Generic Equivalent of Anzupgo

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no generic product of Anzupgo.

Anzupgo Information

Anzupgo Cream at CanadaPharmacyOnline.com

The manufacturer of brand-name Anzupgo Cream (delgocitinib) is Leo. It is available in many countries worldwide, including Canada.

The generic delgocitinib is currently unavailable (at this pharmacy).

Dosage:

Anzupgo is available in the following topical strengths at this pharmacy:
• Cream: 2% in a 60 g tube.

Dosage is individualized.

Usage:

Anzupgo (delgocitinib) cream is a topical Janus kinase (pan-JAK) inhibitor indicated for the treatment of moderate to severe chronic hand eczema (CHE) in adults aged 18 years and older when topical corticosteroids are inadequate or are not advisable for you. Chronic hand eczema (also called chronic hand dermatitis) is a long-term inflammatory skin condition characterized by persistent redness, thickening, cracking, itching, and pain of the skin on the hands and fingers. Anzupgo is applied directly to the skin and is specifically designed to deliver its anti-inflammatory effects locally with minimal systemic (whole-body) absorption.

Mechanism of Action
Delgocitinib is a topical pan-Janus kinase (JAK) inhibitor. It functions by calming an overactive local immune response directly in your skin. Chronic hand eczema causes your skin cells and immune cells to produce hyperactive proteins and enzymes (the JAK-STAT pathway). These enzymes trigger intense redness, skin thickening, painful cracking, and non-stop itching. Anzupgo cream targets and blocks all four branches of these JAK enzymes simultaneously. This reduces inflammation where the cream is applied, allowing your skin barrier to heal. Because this medication is rubbed into the skin rather than swallowed as a pill, it works locally. The amount that reaches your bloodstream is incredibly low, sparing you from the whole-body side effects associated with oral immune-modulating drugs.

Apply Anzupgo cream exactly as your doctor prescribes, following the instructions in the product monograph. Apply a thin layer of Anzupgo cream to the affected areas of skin twice daily (in the morning and evening). Wash your hands after applying the cream, unless your hands are part of the treated area. Avoid applying to the eyes, near the mouth, or on open, actively infected skin lesions. Eczema-related skin cracking or fissures are expected, provided no active bacterial infection is present. This medication is for external use only. The cream should be used only on the skin of the hands and wrists (including between your fingers). Do not apply it to the other areas of your body. Do not use occlusive dressings (airtight bandages) over treated areas unless your doctor directs you to do so. Do not use more than 30 grams of cream every 2 weeks, or a total of 60 grams per month (one full tube).

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Anzupgo, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Anzupgo (delgocitinib) cream. It is not an exhaustive list, and individual reactions can vary. Because Anzupgo is applied topically with low systemic absorption, the risk of whole-body side effects is substantially lower than with oral JAK inhibitors.

Common side effects: These are common side effects of Anzupgo; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Application site reactions (stinging, burning, or irritation at the site of application)
• Folliculitis (infected hair follicles) at the application site
• Pruritus (itching) at the application site

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Serious Infections: Although systemic absorption of delgocitinib from the cream is low, any fever, chills, or signs of a serious infection should be reported to your doctor, particularly in patients who are immunocompromised.
• Severe Allergic Reaction: Hives, rash spreading beyond the application site, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Skin infections at the application site: Worsening redness, swelling, warmth, or pus. Discontinue use and consult your doctor if a skin infection develops.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Anzupgo, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not use Anzupgo/delgocitinib cream if:
• Active serious infection at or near the treatment site.
• Allergies: You have a known hypersensitivity to delgocitinib or any of the cream's ingredients.

Tell your doctor about all of your medical conditions, past and present, before starting Anzupgo. This is crucial as certain conditions affect the drug's safety.
• Any active infections
• History of tuberculosis
• If you are pregnant or breastfeeding
• Immune system conditions

Drug Interactions:

Before using Anzupgo, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the drug's website at https://www.anzupgo.com/

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes. Clinically significant systemic drug interactions with Anzupgo cream are not expected due to its very low systemic absorption. However, inform your doctor of all medications you are taking, including other topical products applied to the same areas.

Pregnancy and Breastfeeding:

There are limited data on the use of Anzupgo cream during pregnancy. As a precaution, Anzupgo should be used during pregnancy only if the potential benefits outweigh the potential risks. Avoid applying to the chest area if breastfeeding to minimize the potential for infant exposure. Discuss the risks and benefits with your doctor.

Use in Children:

Anzupgo cream is approved for use in adults 18 years and older. The safety and efficacy in patients under 18 years of age have not been established.

Frequently Asked Questions about Anzupgo at Canada Pharmacy Online

Why is Anzupgo more affordable in Canada than in the United States?

Prescription drug prices, including Anzupgo, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Anzupgo I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Anzupgo per your doctor's prescription.

Can I buy Anzupgo from you over the counter?

No, Anzupgo requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Anzupgo?

No, the generic equivalent is currently unavailable (at this pharmacy).

Blog Post:

Is It Ringworm or Eczema? How Doctors Spot the Difference

Latest News:

EADV 2025 News: Delgocitinib Cream (Anzupgo, LEO Pharma) Performs Well in Adolescents with Moderate-to-Severe CHE (published Sept 18, 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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