Cosopt (Dorzolamide/Timolol)

Name: Cosopt
Brand: Elvium Life Sciences
SKU: 0268
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Cosopt 60 x 0.2 ml Preservative Free Dose

Manufacturer: Elvium Life Sciences

Country: Canada

Dosage: 2 %/0.5 %

Qty-Price (USD):

Type:

Product: Cosopt Bottle

Manufacturer: Elvium Life Sciences

Country: Canada

Dosage: 2 %/0.5 %/10 ml

Qty-Price (USD):

Generic Equivalent of Cosopt

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Dorzolamide/Timolol Bottle

Manufacturer: Generic

Country: Canada

Dosage: 2 %/0.5 %/10 ml

Qty-Price (USD):

Type:

Product: Dorzolamide/Timolol Bottle

Manufacturer: Generic

Country: India

Dosage: 2 %/0.5 %/5 ml

Qty-Price (USD):

Cosopt Information

medically reviewed by Carol Hou (BSc. Pharm) on August 29, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Cosopt and Dorzolamide Hydrochloride/Timolol Maleate at CanadaPharmacyOnline.com

The brand Cosopt is marketed and distributed by Elvium Life Sciences in Canada.

Generic dorzolamide hydrochloride/timolol maleate is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Cosopt:

Generic dorzolamide hydrochloride/timolol maleate contains the same active ingredients as the brand-name Cosopt. It is required to meet the same safety, effectiveness, and quality standards as the brand-name product. This means it is designed to work in the same way as dorzolamide hydrochloride/timolol maleate, also known as Cosopt. Studies have demonstrated bioequivalence between generic and brand-name dorzolamide hydrochloride/timolol maleate, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic dorzolamide hydrochloride/timolol maleate, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage

Both the brand-name medication Cosopt and its generic equivalent, dorzolamide hydrochloride/timolol maleate, are available as ophthalmic solutions (eye drops) in a fixed combination of concentrations: 2% dorzolamide and 0.5% timolol.

These eye drops are typically supplied in two main formats:
• Preservative-free single-use vials: Often packaged as 60 individual 0.2 mL unit-dose containers, designed for those who may be sensitive to preservatives or for whom a preservative-free formulation is otherwise advisable.
• Multi-dose bottles: Commonly available in 10 mL bottles, containing a preservative (e.g., benzalkonium chloride) to prevent contamination.

Generic dorzolamide hydrochloride/timolol maleate ophthalmic solutions are available in both 5 mL bottles (approximately 5 mL×20 drops/mL=100 drops) and 10 mL bottles (approximately 10 mL×20 drops/mL=200 drops).

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage

Cosopt (dorzolamide hydrochloride/timolol maleate) is a prescription medication used to decrease elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Common uses include:
• Elevated Intraocular Pressure: Reduction of pressure inside the eye in patients with open-angle glaucoma or ocular hypertension when monotherapy with a beta-blocker is not sufficient.

Mechanism of Action
Cosopt is a fixed combination of two active ingredients, dorzolamide hydrochloride and timolol maleate, which work synergistically to reduce elevated intraocular pressure (IOP).
• Dorzolamide Hydrochloride: This is a topical inhibitor of carbonic anhydrase. It works by inhibiting the enzyme carbonic anhydrase in the ciliary body of the eye. This inhibition reduces the secretion of aqueous humor (the fluid that fills the front part of the eye), thereby lowering IOP.
• Timolol Maleate: This is a non-selective beta-adrenergic receptor blocking agent. When applied topically to the eye, it reduces elevated and normal IOP, likely by decreasing the production of aqueous humor and possibly by increasing its outflow.

The combined action of both agents results in a more significant reduction in IOP than either agent used alone.

Take Cosopt exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Cosopt, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Cosopt, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Cosopt; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.

Eye-related:
• Blurred vision
• Burning or stinging (transient)
• Dry eyes
• Itching
• Pain
• Foreign body sensation
• Inflammation of the eyelid (blepharitis)
• Light sensitivity (photophobia)
• Redness (conjunctival hyperemia)

Other:
• Bitter, sour, unusual taste in the mouth
• Headache
• Nausea

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Severe rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, wheezing, itching.
• Cardiac effects:
o Arrhythmia (irregular heartbeat)
o Bradycardia (slow heart rate)
o Congestive heart failure
o Heart block
o Hypotension (low blood pressure)
o Palpitations
o Syncope (fainting)
• Bronchospasm/Respiratory distress: Shortness of breath, wheezing, difficulty breathing, particularly in patients with pre-existing asthma or COPD.
• Central nervous system (CNS) effects:
o Depression
o Dizziness
o Hallucinations
o Insomnia, nightmares, memory loss
o Paresthesia (tingling, prickling, or numbness sensation)
o Cerebrovascular accident (stroke) or cerebral ischemia (very rare)
o Exacerbation of myasthenia gravis or myasthenic symptoms (e.g., double vision, drooping eyelids, generalized weakness)
• Ocular reactions:
o Choroidal detachment (rare, usually after filtration surgery)
o Macular edema (swelling in the retina)
o Iridocyclitis (inflammation of the iris and ciliary body)
o Corneal edema (swelling of the cornea)
o Detached retina
• Systemic absorption: Although administered topically, Cosopt can be absorbed systemically, leading to systemic side effects associated with beta-blockers and carbonic anhydrase inhibitors.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Cosopt, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Cosopt should not be used if:
• You are allergic to dorzolamide, timolol, or any other ingredient in Cosopt.
• You have a history of bronchial asthma or severe chronic obstructive pulmonary disease (COPD).
• You have sinus bradycardia (slow heart rate), second or third degree atrioventricular block, overt cardiac failure, or cardiogenic shock.
• You have severe renal impairment (kidney disease) or hyperchloremic acidosis.

Tell your doctor about all of your medical conditions, past and present, before starting Cosopt. This is crucial because certain conditions affect whether Cosopt is right for you. These conditions may include, but are not limited to:
• Acute angle-closure glaucoma (Cosopt has not been studied in this condition and requires different therapeutic interventions). • Cardiovascular disease (e.g., heart failure, bradycardia, heart block, severe peripheral circulatory disturbance like severe Raynaud's phenomenon or claudication).
• Cerebrovascular insufficiency.
• Diabetes mellitus (due to potential for masking hypoglycemia symptoms).
• Hyperthyroidism (due to potential for masking symptoms).
• Kidney impairment (mild to moderate).
• Liver impairment (use with caution as it has not been studied).
• Myasthenia gravis or history of myasthenic symptoms (due to potential for worsening muscle weakness).
• Recent eye surgery or trauma (increased risk of bacterial keratitis with multi-dose ophthalmic products).
• Sulfa allergy (due to the dorzolamide component, which is a sulfonamide; risk of severe systemic allergic reactions).
• Patients with low endothelial cell counts (increased potential for corneal edema)

Drug Interactions

Before taking Cosopt, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official prescribing information | Elvium Life Sciences at https://www.elvium.ca/wp-content/uploads/COSOPT-EN-PM.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Cosopt. Cosopt may interact with other medicines, but is not limited to:
• Adrenaline (Epinephrine): Beta-blockers can block the systemic effects of administered adrenaline (epinephrine) in cases of allergic reactions. Use with caution in patients with a history of atopy or severe anaphylaxis.
• Beta-adrenergic Blocking Agents (oral or ophthalmic): Concomitant use with Cosopt may result in additive systemic beta-blockade, leading to an increased risk of side effects, including reduced heart rate, blood pressure, and respiratory depression.
• Calcium Channel Blockers (e.g., verapamil, diltiazem): Potential for additive effects on heart rate, blood pressure, and cardiac conduction. • Catecholamine-depleting drugs (e.g., reserpine, guanethidine): Concomitant use with beta-blockers can lead to additive effects and possibly produce hypotension and/or marked bradycardia, potentially causing syncope.
• Clonidine: If clonidine is abruptly withdrawn while a patient is receiving a beta-blocker, rebound hypertension can occur.
• Digitalis/Digoxin: Concomitant use with beta-blockers may increase the risk of bradycardia and AV conduction abnormalities.
• Monoamine Oxidase Inhibitors (MAOIs): Caution should be exercised due to the potential for additive effects on blood pressure.
• Mydriatics (e.g., dipivefrin, epinephrine): May cause mydriasis (dilation of pupil) when co-administered with timolol.
• Oral Carbonic Anhydrase Inhibitors (e.g., acetazolamide): Concomitant use with topical Cosopt is not recommended due to the potential for additive systemic effects (e.g., acid-base disturbances, electrolyte abnormalities).
• Potent CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine, quinidine): These drugs are strong inhibitors of CYP2D6 and can significantly increase systemic exposure to timolol, potentially leading to increased beta-blockade and serious side effects.

Pregnancy and Breastfeeding

Cosopt should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies in pregnant women. Animal studies have shown reproductive toxicity with both dorzolamide and timolol. If you are pregnant or planning to become pregnant, discuss this with your doctor.

Timolol maleate is excreted in human milk. It is not known whether dorzolamide is excreted in human milk. Due to the potential for severe adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor for personalized advice.

Use in Children

The safety and effectiveness of Cosopt in pediatric patients have not been established. Use in children is generally not recommended unless specifically determined by a specialist for compelling reasons.

Use in the Elderly

No overall differences in safety or effectiveness have been observed between elderly and younger patients. However, caution should be exercised in elderly patients with a history of cardiac disease due to the systemic effects of timolol.

Frequently Asked Questions about Cosopt at Canada Pharmacy Online:

Why is Cosopt more affordable in Canada than in the United States?

Prescription drug prices, including Cosopt, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Cosopt at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Cosopt requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the best time to take Cosopt?

Cosopt is typically administered as one drop in the affected eye(s) two times daily. It is essential to administer the doses evenly (e.g., morning and evening) to maintain consistent control of intraocular pressure. Follow your doctor's specific instructions.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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