Creon (Pancreatic Enzymes (Lipase, Protease, Amylase))

Name: Creon
Brand: BGP Pharma/Mylan
SKU: 0290
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Creon Granules 20gm

Manufacturer: BGP Pharma/Mylan

Country: Canada

Dosage: Micro

Qty-Price (USD):

Type:

Product: Creon Capsule

Manufacturer: BGP Pharma/Mylan

Country: Canada

Dosage: 10

Qty-Price (USD):

Type:

Product: Creon Capsule

Manufacturer: BGP Pharma/Mylan

Country: Canada

Dosage: 25

Qty-Price (USD):

Type:

Product: Creon Capsule (Limited Supply)

Manufacturer: BGP Pharma/Mylan

Country: Canada

Dosage: 35

Qty-Price (USD):

Generic Equivalent of Creon

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no generic product of Creon.

Creon Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on September 8, 2025.

Creon and Pancrelipase at CanadaPharmacyOnline.com

The brand-name drug Creon (pancrelipase) is manufactured by BGP Pharma/Mylan and is available in various countries, including Canada.

The generic version is currently unavailable (at this pharmacy).

Dosage:

(At this pharmacy) The brand Creon is available as: Creon micro granules (Canada): 5,000 Ph. Eur.. units of lipase, 5,100 Ph. Eur.. units of amylase, and 320 Ph. Eur.. units of protease (or 5,000/5,100/320).

Creon Capsules (Ph. Eur.. units) are available as:
• Creon 10: Lipase 10,000, Amylase 11,200, Protease 730 (This strength is generally considered therapeutically comparable to Creon 12,000 USP units in the USA, although the exact amylase and protease units may differ slightly due to varying assay methods.)
• Creon 25: Lipase 25,000, Amylase 25,500, Protease 1,600 (This strength is generally considered therapeutically comparable to Creon 24,000 USP units in the USA, although the exact amylase and protease units may differ slightly due to varying assay methods.)
• Creon 35: Lipase 35,000, Amylase 35,700, Protease 2,240 (This strength is generally considered therapeutically comparable to Creon 36,000 USP units in the USA, although the exact amylase and protease units may differ slightly due to varying assay methods.)

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Creon is a prescription medication primarily used to treat exocrine pancreatic insufficiency (EPI) due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions. Creon's primary active ingredient is pancrelipase (lipase, amylase, protease), a combination of digestive enzymes extracted from the pancreas of pigs. EPI is a condition where the pancreas doesn't produce enough digestive enzymes (like lipase, amylase, and protease) to properly break down fats, proteins, and carbohydrates in food. This leads to malabsorption of nutrients and symptoms such as abdominal pain, bloating, diarrhea, steatorrhea, and weight loss.

Mechanism of Action:
Creon is a pancreatic enzyme replacement therapy (PERT) that provides exogenous lipase, protease, and amylase to aid in the digestion of fats, proteins, and carbohydrates in individuals with exocrine pancreatic insufficiency (EPI). Its mechanism involves the delivery of these enzymes in an enteric-coated, delayed-release formulation, protecting them from gastric acid denaturation. Once the microspheres reach the small intestine and the pH rises above a specific threshold (typically around pH 5.5), the coating dissolves, releasing the active enzymes. These enzymes then mix with the chyme, facilitating the breakdown of macronutrients into absorbable forms, thereby improving nutrient absorption and alleviating malabsorption symptoms associated with EPI.

Take Creon exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Creon, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Creon (pancrelipase). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Creon, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Changes in blood sugar (hyperglycemia and hypoglycemia) - These are common side effects reported with Creon, especially in patients with underlying pancreatic conditions (e.g., cystic fibrosis, chronic pancreatitis) that affect enzyme production and insulin regulation.
• Dizziness
• Gastrointestinal issues such as frequent or abnormal bowel movements, gas, stomach pain or discomfort, and vomiting
• Headache
• Sore throat and cough

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic Reactions: While rare, severe allergic reactions can occur. Symptoms include trouble breathing, skin rashes, swollen lips, itching, hives, or swelling of the face, mouth, or throat.
• Fibrosing Colonopathy: This is a rare but serious bowel disorder involving scarring or thickening of the colon. It's more common in children with cystic fibrosis who take very high doses of Creon. Symptoms include unusual or severe abdominal pain, bloating, trouble passing stool, nausea, vomiting, or diarrhea.
• Increased Blood Uric Acid Levels (Hyperuricemia): This can lead to gout (pain, stiffness, redness, or swelling in joints, especially the big toe) or kidney stones.
• Mouth Irritation: If the capsules are chewed, crushed, or held in the mouth, they can cause irritation, sores, or ulcers in the mouth or tongue. Creon capsules should always be swallowed whole with enough liquid.
• Possible Viral Infection: Creon is made from the pancreas of pigs. While never reported, there's a theoretical possibility of viral transmission from pigs.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Creon, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Creon should not be used if you:
• Have had an allergic reaction or hypersensitivity to Creon, its ingredients, or porcine (pig) proteins.

Tell your doctor about your medical conditions, past and present, before starting Creon. This is crucial because certain conditions can affect whether Creon is right for you. These conditions may include, but are not limited to:
• Fibrosing Colonopathy: This is a rare but serious bowel disorder characterized by scarring or thickening of the colon wall. It has been primarily reported in children with cystic fibrosis who receive very high doses of pancreatic enzyme supplements over a long period. High doses of pancrelipase (especially exceeding 6,000 lipase units/kg per meal) are a risk factor. Patients, especially children with cystic fibrosis, should be monitored for unusual abdominal symptoms like severe stomach pain, bloating, constipation, nausea, vomiting, or diarrhea.
• Hyperuricemia/Gout/Kidney Disease: Pancrelipase can increase uric acid levels in the blood, particularly at high doses. Patients with gout, hyperuricemia, or kidney problems should be monitored closely for symptoms like joint pain, stiffness, or swelling.
• Lactose Intolerance: Creon formulations generally do not contain lactose. However, patients with dietary intolerance should always verify the ingredients in the most current product monograph or consult their pharmacist.
• Oral Mucosal Irritation: The enzyme contents can irritate the mouth and throat if the capsules are chewed, crushed, or held in the mouth. It's crucial to swallow the capsules whole with adequate liquid.
• Risk of Viral Transmission: Since pancrelipase is derived from pigs, there's a theoretical, though very low, risk of transmitting viral diseases. However, no cases of infectious illness transmission associated with porcine pancreatic extracts have been reported.

Drug Interactions:

Before taking Creon, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Creon prescribing information: https://www.rxabbvie.com/pdf/creon_pi.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Creon. Creon may interact with other medications, but is not limited to:
• Alpha-glucosidase Inhibitors (e.g., acarbose, miglitol): Creon can reduce the effectiveness of these diabetes medications. Alpha-glucosidase inhibitors work by slowing down the breakdown of carbohydrates, and pancrelipase (the active ingredient in Creon) is an enzyme that helps break down carbohydrates.
• Antacids (containing calcium carbonate, magnesium hydroxide, aluminum hydroxide, or sodium bicarbonate): These can decrease the effectiveness of Creon by potentially causing premature dissolution of the enteric coating in the stomach, leading to inactivation of the enzymes by gastric acid. It is often recommended to space out the administration of Creon and antacids by at least 1-2 hours to minimize this interaction.
• Folic Acid: Creon may decrease the absorption of folic acid, potentially leading to folic acid deficiency. To minimize this interaction, it may be advisable to space out the administration of Creon and folic acid supplements as much as possible.
• Iron Salts (e.g., ferrous fumarate, ferrous gluconate, ferrous sulfate, ferric maltol, polysaccharide iron): Creon may decrease the absorption of some oral iron supplements, potentially leading to lower iron levels. To minimize this interaction, it may be advisable to space out the administration of Creon and iron supplements as much as possible.

Pregnancy and Breastfeeding

For pregnant or breastfeeding individuals, Creon (pancrelipase) is generally considered a safe option. This medication acts as a replacement for the digestive enzymes your body would normally make, so it's not significantly absorbed into your system. This means it's not expected to cross the placenta to the baby or pass into breast milk in any meaningful amount.

While there haven't been many large-scale studies on Creon during pregnancy and breastfeeding, existing reports haven't shown any increased risk of harm to the fetus. The main reason to continue taking Creon is to ensure you and your baby get the proper nutrients. Without it, untreated pancreatic issues can lead to malnutrition, which poses a far greater risk.

It is always best to talk to your doctor about the benefits and risks before you start or continue using Creon while pregnant or breastfeeding.

Use in Children

While essential for children with pancreatic insufficiency (e.g., cystic fibrosis), the dosage needs to be carefully managed, and the risk of fibrosing colonopathy is particularly relevant in this population. Safety and efficacy have not been established in infants younger than 6 months for some formulations.

Frequently Asked Questions about Creon at Canada Pharmacy Online:

Why is Creon more affordable in Canada than in the United States?

Prescription drug prices, including Creon, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

What is the difference between Creon 10 and Creon 25?

The dosage difference represents the different amounts of the same active ingredient (pancrelipase) present in each capsule.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of three months of Creon at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Creon requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 and 18 business days to receive your order from our pharmacy.

How should I take Creon?

Always take Creon with every meal and snack. The enzymes need to mix with your food to help with digestion.

Can I split Creon capsules?

Swallow capsules whole. Do not crush, chew, or hold the capsules or their contents in your mouth, as this can cause mouth irritation and alter how the medication works. If you have trouble swallowing capsules, you can open the capsule and sprinkle the contents on a small amount of room-temperature, acidic food like applesauce, bananas, or plain Greek yogurt. Make sure to swallow the mixture right away with enough liquid. Do not store food mixed with Creon.

Will Creon cure my condition?

No, Creon does not cure EPI. It helps replace the digestive enzymes your pancreas no longer makes, manage the symptoms and help your body absorb nutrients. EPI is typically a long-term condition, and Creon is usually taken long-term to manage it. If you stop taking Creon, your EPI symptoms (like stomach pain, diarrhea, and weight loss) are likely to return or worsen.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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