Domperidone (Domperidone)

Name: Domperidone
Brand: Generic
SKU: 7352
Availability: InStock

Type

Product

Manufacturer

Country

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Qty-Price (USD)

There is no brand product of Domperidone.

Generic Equivalent of Domperidone

Type

Product

Manufacturer

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Dosage

Qty-Price (USD)

Type:

Product: Domperidone Tablet

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Domperidone Information

medically reviewed by Dr. Bolanle Aina, Pharmacist on September 3, 2025.

Domperidone at CanadaPharmacyOnline.com

The brand name of domperidone is currently unavailable (at this pharmacy).

Generic domperidone is sourced from manufacturers that meet the applicable quality regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Domperidone:

Generic domperidone contains the same active ingredient as brand-name Motilium and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Motilium. Studies have demonstrated similar absorption rates, but individual responses can still vary. If you have any questions about using generic domperidone, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs.

Dosage:

Domperidone is commonly available in 10 mg oral tablets (5 mg tablets also exist but are not currently available at this pharmacy).

Your doctor will determine the appropriate starting and maximum doses based on your individual needs and health situation.

Usage:

Domperidone is a prescription medication primarily used to treat symptoms of nausea, vomiting, and stomach discomfort, such as bloating. It is particularly effective in managing symptoms related to delayed gastric emptying (gastroparesis) and nausea caused by various factors, including migraines and certain medications used to treat Parkinson's disease.

Mechanism of Action:
Domperidone functions as a dopamine antagonist, specifically targeting D2 and D3 receptors. It works by increasing motility in the upper gastrointestinal tract. This action involves strengthening contractions of the stomach muscles, which helps to accelerate the movement of food from the stomach into the small intestine. This prokinetic effect reduces feelings of fullness and helps alleviate nausea and vomiting.

Take Domperidone exactly as prescribed by your doctor, following the instructions provided in the About domperidone from nhs.uk. Consult your doctor for personalized guidance.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Domperidone, it is essential to discuss all potential side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

This is a partial list of side effects; individual reactions can vary. Before starting Domperidone, you should discuss all potential side effects and risks with your doctor or pharmacist.

Common Side Effects: These are some of the most frequently reported side effects. You should contact your doctor promptly if any of these symptoms persist, worsen, or if you experience other concerning symptoms.
• Changes in appetite
• Constipation
• Diarrhea
• Dizziness or drowsiness
• Dry mouth
• Headache
• Insomnia
• Upset stomach

Serious Side Effects: Domperidone carries a risk of serious, potentially fatal, cardiac side effects. Any symptoms related to your heart should be treated as a medical emergency. You must stop taking Domperidone and seek immediate medical attention if you experience any of the following, even if they seem minor:
• Allergic reactions: Symptoms may include hives, itching, rash, swelling of the face or tongue, or difficulty breathing.
• Heart-related symptoms: Irregular heartbeat, palpitations, or any changes in your heart rhythm.
• Neurological symptoms: Seizures or uncontrollable muscle movements (tardive dyskinesia).
• Hormonal effects: Galactorrhea (breast milk production in non-breastfeeding individuals), gynecomastia (breast enlargement in males), or menstrual irregularities.
• Other serious symptoms: Severe dizziness or fainting.

Contraindications:

Domperidone is contraindicated (should not be used) in patients with the following medical conditions:
• Cardiac Conditions: Pre-existing heart conditions, including a prolonged QT interval, a history of arrhythmia, or congestive heart failure.
• Certain Concurrent Medications: Simultaneous use with drugs that prolong the QT interval and/or are potent CYP3A4 inhibitors.
• Electrolyte Imbalances: Uncorrected imbalances of electrolytes such as potassium or magnesium.
• Known Hypersensitivity: A confirmed allergy to domperidone or any of its inactive ingredients. An allergic reaction can include a rash, itching, swelling, severe dizziness, or trouble breathing.
• Prolactinoma: A tumor on the pituitary gland that secretes prolactin.
• Significant Hepatic Impairment: Moderate to severe liver disease.

Important Considerations Before Use
Because of the risk of serious cardiac side effects, Domperidone is not approved for use in the United States. Before starting this medication, it is crucial to discuss your complete medical history with your doctor or pharmacist. This is because certain conditions may affect its safety and suitability for you, including but not limited to:
• Cardiac Conditions: Any history of heart disease, heart rhythm disorders (arrhythmias), or a prolonged QT interval.
• Electrolyte Imbalances: Current or past issues with potassium, magnesium, or other electrolyte imbalances.
• Gastrointestinal Conditions: While domperidone is used for some GI issues, certain conditions like gastrointestinal bleeding, obstruction, or perforation are contraindications.
• Neurological Conditions: A history of seizures or movement disorders.
• Renal Impairment: Significant kidney problems.

Driving and Operating Machinery
Due to the potential for side effects such as dizziness, drowsiness, and cardiac arrhythmias, caution is advised when driving or operating machinery that requires attention. These adverse effects can significantly impair your judgment, coordination, and reaction time, thereby increasing the risk of accidents. It is recommended to understand how this medication affects you before engaging in such activities.

Drug Interactions:

Before taking Domperidone, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the HealthLink BC website at: https://www.healthlinkbc.ca/healthwise/domperidone-oral.

Provide your doctor with a complete list of all your medications, including over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes you are making, as these may interact with Domperidone. Domperidone may interact with other medicines, but is not limited to:
• Antifungals: e.g., ketoconazole, itraconazole
• Antibiotics: e.g., erythromycin, clarithromycin
• HIV medications: e.g., ritonavir, saquinavir
• Antidepressants: e.g., nefazodone
• Antiarrhythmics: e.g., amiodarone, quinidine
• Certain cancer medications
• Certain stomach medications

Food and Substance Interactions
• Alcohol: Excessive alcohol consumption can worsen central nervous system effects such as dizziness and drowsiness.
• Grapefruit and Grapefruit Juice: Consuming grapefruit or its juice can inhibit the CYP3A4 enzyme, similarly to certain medications, potentially increasing domperidone levels and the risk of cardiac side effects.
• Marijuana: The use of marijuana should be discussed with your doctor due to potential interactions.

Pregnancy and Breastfeeding:

It is essential to inform your doctor if you are pregnant, become pregnant, are breastfeeding, or plan to breastfeed before taking Domperidone. Domperidone is not widely recommended during pregnancy and breastfeeding, as its safety is still being evaluated. While some studies have found small amounts of the drug pass into breast milk, the long-term effects on a nursing infant are not fully established. Similarly, its safety for an unborn baby is not conclusively proven, although some small-scale studies have not shown an increased risk of birth defects.

Your doctor can help you weigh the potential benefits of the medication against the potential, though not fully known, risks to the unborn or nursing infant. Always discuss your complete medical history and any other medications you are taking with your doctor to make an informed decision about your treatment.

Frequently Asked Questions about Domperidone at Canada Pharmacy Online:

Why is Domperidone more affordable in Canada than in the United States?

Prescription drug prices, including domperidone, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

Does the generic Domperidone have lactose and gluten?

The Pharmaris and Apotex versions are lactose-free, but the Teva version contains lactose. They are all gluten-free.

Should Domperidone be considered as a treatment for milk production?

Domperidone is not approved for the purpose of increasing breast milk production.

Is Domperidone safe for my dog?

The active drug in Motilium for vomiting is domperidone. At the correct dose, this drug is not toxic to dogs; however, it is not recommended to give domperidone to dogs unless specifically instructed to do so by a veterinarian. This is because its anti-sickness action could mask an undiagnosed problem with potentially serious consequences. In addition, in some cases, domperidone can cause the stomach to stop contracting entirely, leading to a complication called gastric stasis.

How to take a Domperidone tablet?

It's best to take domperidone before food. Take it 15 to 30 minutes before a meal or snack. Swallow the tablet whole with a glass of water. Do not crush or chew it (source).

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is committed to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about ordering, please visit our How to Order page.

Is there a limit on how many Domperidone tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of domperidone at once, per your doctor's prescription.

Can I buy Domperidone over the counter from you?

No, Domperidone requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

How long does it take Domperidone to work for nausea?

Domperidone should begin to take effect within 30 to 60 minutes. Domperidone blocks messages between parts of your brain called the chemoreceptor trigger zone (CTZ) and the vomiting centre. This helps stop nausea and prevent vomiting (source).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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