Emend (Aprepitant)

Name: Emend
Brand: Merck
SKU: 6529
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Emend

Manufacturer: Merck

Country: Canada

Dosage: 80 mg

Qty-Price (USD):

Type:

Product: Emend

Manufacturer: Merck

Country: Canada

Dosage: 125 mg

Qty-Price (USD):

Type:

Product: Emend Tri-Fold Pack

Manufacturer: Merck

Country: Canada

Dosage: 125 mg/80 mg/80 mg

Qty-Price (USD):

Generic Equivalent of Emend

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Aprepitant Tri-Fold Pack (Aprecap-Glenmark)

Manufacturer: Generic

Country: India

Dosage: 125 mg/80 mg/80 mg

Qty-Price (USD):

Emend Information

Emend and Aprepitant at CanadaPharmacyOnline.com

The manufacturer of the brand-name Emend (aprepitant) is MSD (Merck Sharp & Dohme), and it is available in many countries worldwide, including Canada and Turkey.

Generic aprepitant is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Aprepitant

Generic aprepitant contains the same active ingredient as brand-name Emend. It must meet the same effectiveness and quality standards. Studies have shown that generic aprepitant is bioequivalent to brand-name Emend, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses can vary.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Emend (aprepitant) is available in the following oral strengths at this pharmacy:
• Capsules: 80 mg and 125 mg.
• Tri-fold pack: 125 mg/80 mg/80 mg.

Dosage is individualized and depends on the condition. Emend should be taken with or without food. Swallow capsules whole.

Usage:

Emend (aprepitant) is indicated for the prevention of acute and delayed nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy, as part of a combination antiemetic regimen. It is also indicated for the prevention of post-operative nausea and vomiting (PONV). Emend does not treat nausea and vomiting after they have already started. It is used preventively, before chemotherapy or surgery.

Mechanism of Action
Aprepitant, the active ingredient in Emend, works by selectively blocking the binding of substance P (a neuropeptide) to neurokinin-1 (NK1) receptors in the brain, particularly in the vomiting center (area postrema) and the gut. Substance P and NK1 receptors play a central role in triggering the delayed vomiting response that occurs 24–48 hours after chemotherapy. By blocking NK1 receptors, aprepitant prevents both the acute and the delayed phases of chemotherapy-induced nausea and vomiting. When combined with a serotonin (5-HT3) antagonist (which primarily prevents acute-phase vomiting) and a corticosteroid, the three-drug regimen provides the most comprehensive prevention available.

Take Emend exactly as your doctor or oncologist prescribes, as directed in the Product Monograph. It is taken as a 3-day course starting on the day of chemotherapy.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Emend, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Emend (aprepitant). It is not an exhaustive list, and individual reactions can vary. Many side effects reported during clinical trials may also be attributable to the chemotherapy itself.

Common side effects: These are common side effects of Emend; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Constipation or diarrhea
• Fatigue
• Headache
• Hiccups
• Loss of appetite
• Nausea (despite the antiemetic, mild nausea may still occur)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Liver Problems: Jaundice (yellowing of skin or eyes), dark urine, or severe upper abdominal pain. Elevated liver enzymes have been reported.
• Severe Allergic Reaction (Hypersensitivity): Hives, swelling of the face, lips, tongue, or throat, difficulty breathing, or anaphylaxis. Rarely reported with aprepitant.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Emend, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Emend/aprepitant if:
• Allergies: Known hypersensitivity to aprepitant, polysorbate 80, or any ingredient in the capsule.
• Concurrent use of pimozide, cisapride, terfenadine, or astemizole: Aprepitant is a CYP3A4 inhibitor. Combining it with these drugs can cause dangerous elevations in their blood levels and potentially fatal cardiac arrhythmias.

Tell your doctor about all of your medical conditions, past and present, before starting Emend. This is crucial as certain conditions affect the drug's safety.
• Liver disease

Drug Interactions:

Before taking Emend, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the product monograph at https://www.merck.ca/en/wp-content/uploads/sites/20/2021/04/EMEND-PM_E.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Emend. Emend may interact with other medicines, including but not limited to:
• Chemotherapy agents metabolized by CYP3A4 (e.g., docetaxel, paclitaxel, etoposide, ifosfamide, imatinib, vinorelbine): Aprepitant may raise levels of these drugs; your oncologist will account for this.
• Corticosteroids (e.g., dexamethasone, methylprednisolone): Aprepitant inhibits their metabolism, raising their blood levels. When dexamethasone is part of the antiemetic regimen, the dose is typically halved when Emend is used.
• Hormonal contraceptives (the pill, patch, ring): Aprepitant reduces the effectiveness of hormonal contraceptives during treatment and for 28 days after the last Emend dose. Use an additional non-hormonal method of contraception during this period.
• Warfarin: Aprepitant may initially raise, then lower warfarin blood levels. Monitor INR closely during Emend treatment and for 2 weeks after.

Pregnancy and Breastfeeding:

Emend should be used during pregnancy only if clearly necessary. As aprepitant reduces the effectiveness of hormonal contraceptives, women of childbearing potential must use a reliable back-up non-hormonal method of contraception (such as condoms or a barrier method) during treatment and for 28 days after the last dose. It is not known whether aprepitant is excreted in breast milk; breastfeeding is not recommended while taking Emend.

Use in Children:

Emend is approved for use in children 6 months of age and older for the prevention of nausea and vomiting associated with highly and moderately emetogenic chemotherapy. Dosing is weight-based and determined by a specialist. Oral capsules are used in children who can swallow capsules. A suspension formulation may be used for younger children.

Frequently Asked Questions about Emend at Canada Pharmacy Online

Why is Emend more affordable in Canada than in the United States?

Prescription drug prices, including Emend, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Emend I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Emend per prescription from your doctor.

Can I buy Emend from you over the counter?

No, Emend requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Emend?

Yes, generic aprepitant capsules are available at this pharmacy in 80 mg and 125 mg strengths, manufactured in Canada.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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