Gilotrif (Afatinib Dimaleate)

Name: Gilotrif
Brand: Boehringer Ingelheim
SKU: 7175
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Gilotrif Tablet

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Gilotrif Tablet (ON BACKORDER)

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Gilotrif Tablet (ON BACKORDER)

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Generic Equivalent of Gilotrif

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Afatinib Dimaleate Tablet

Manufacturer: Generic

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Afatinib Dimaleate Tablet

Manufacturer: Generic

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Afatinib Dimaleate Tablet

Manufacturer: Generic

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Gilotrif Information

Gilotrif and Afatinib Dimaleate at CanadaPharmacyOnline.com

The manufacturer of brand-name Gilotrif (afatinib) is Boehringer Ingelheim Canada Ltd. Gilotrif is available at this pharmacy in 20 mg, 30 mg, and 40 mg strengths.

Generic afatinib dimaleate is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards. Generic afatinib dimaleate is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Afatinib Dimaleate

Generic afatinib dimaleate contains the same active ingredient as brand-name Gilotrif. It must meet the same effectiveness and quality standards. This means it is designed to work like Gilotrif. Studies have shown that generic afatinib dimaleate is bioequivalent to brand-name Gilotrif, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Gilotrif (afatinib dimaleate) is available in the following oral strengths at this pharmacy:
• Tablets: 20 mg, 30 mg, and 40 mg.

Dosage is individualized and may be adjusted by your oncologist based on tolerability.

Usage:

Gilotrif (afatinib) is indicated for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors have certain EGFR (epidermal growth factor receptor) mutations. It is specifically used when the tumor harbors EGFR exon 19 deletions or the exon 21 (L858R) substitution mutation, as confirmed by an approved diagnostic test. Gilotrif is also approved for the treatment of patients with advanced or metastatic squamous cell carcinoma of the lung that has progressed after prior platinum-based chemotherapy.

Mechanism of Action
Afatinib, the active ingredient in Gilotrif, is a selective, irreversible inhibitor of the ErbB family of protein kinases, including EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4). Many non-small cell lung cancers harbor mutations in the EGFR gene that permanently activate the receptor, driving uncontrolled cell growth. By covalently binding to and irreversibly blocking multiple ErbB kinases, afatinib blocks the signaling pathways that cancer cells rely on to grow, divide, and survive. The irreversible (covalent) binding distinguishes afatinib from first-generation EGFR inhibitors (gefitinib, erlotinib), which bind reversibly.

Take Gilotrif exactly as your oncologist prescribes, as outlined in the Product Monograph. Take on an empty stomach, at least 1 hour before or 2 hours after a meal. Food significantly reduces the absorption and effectiveness of this medication. Swallow tablets whole with water. Do not crush or chew the tablets. Contact your oncology team before stopping or reducing your dose.

The information below summarizes some, but not all, potential side effects, risks, and interactions.Before starting Gilotrif, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Gilotrif (afatinib). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Gilotrif; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Acne-like skin rash (occurs in the majority of patients; usually on the face, chest, and back)
• Diarrhea (very common and can be dose-limiting; speak to your doctor about having an anti-diarrheal medication, like loperamide, on hand before starting treatment)
• Mouth sores (stomatitis)
• Nail and skin changes (paronychia — painful inflammation of the nail folds)
• Nausea or loss of appetite

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Interstitial Lung Disease (ILD) / Pneumonitis: New or worsening shortness of breath, cough, or fever. Any new respiratory symptoms during treatment require urgent evaluation. Gilotrif must be stopped immediately if ILD is suspected or confirmed.
• Left Ventricular Dysfunction / Cardiotoxicity: Sudden unexplained shortness of breath, a rapid or irregular heartbeat, or severe swelling in your ankles or feet. Left ventricular ejection fraction (LVEF) is tracked periodically if you have underlying cardiac risk factors.
• Liver Toxicity: Jaundice (yellowing of the skin or eyes), dark urine, severe fatigue, or right upper abdominal pain. Liver function is monitored regularly via blood tests during treatment.
• Ocular Toxicity: Eye pain, severe redness, visual changes, or light sensitivity (keratitis). Avoid wearing contact lenses during treatment if you develop eye symptoms.
• Severe Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Severe Diarrhea: Diarrhea that is frequent, watery, or bloody, or that causes significant dehydration, weight loss, or prevents eating. Contact your oncology team immediately; dose modification or a treatment break may be needed.
• Severe Skin Reactions: Extensive blistering, peeling, or open sores. Skin reactions are very common with Gilotrif, and most are mild, but severe bullous and erosive reactions have been reported. Protect your skin from sun exposure by using sunscreen and wearing protective clothing.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Gilotrif, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Gilotrif/afatinib if:
• Allergies: Known hypersensitivity to afatinib or any ingredient in the tablet.

Tell your doctor about all of your medical conditions, past and present, before starting Gilotrif. This is crucial as certain conditions affect the drug's safety.
• Existing lung problems
• Eye conditions
• If you are dehydrated
• Kidney disease
• Liver disease

Drug Interactions:

Before taking Gilotrif, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the prescribing information at https://pro.boehringer-ingelheim.com/ph/oncology/giotrif/prescribing-information.

Afatinib does not rely heavily on liver enzymes (CYP450) for metabolism, but it interacts significantly with the transporter P-glycoprotein (P-gp). Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Gilotrif. Gilotrif may interact with other medicines, including but not limited to:
• P-gp inhibitors (e.g., ritonavir, clarithromycin, amiodarone, verapamil, itraconazole): May increase afatinib plasma concentrations. If co-administration is necessary, monitor for afatinib toxicity, and your doctor may advise altering the timing of your doses.
• P-gp inducers (e.g., rifampicin, carbamazepine, phenytoin, St. John's Wort): May decrease afatinib levels, potentially reducing effectiveness.

Pregnancy and Breastfeeding:

Gilotrif can cause harm to an unborn baby. Women of childbearing potential must have a pregnancy test before starting treatment and use highly effective contraception during treatment and for 1 month after the final dose. Male patients with female partners of childbearing potential should also use effective contraception during treatment and for 1 month after the last dose. Gilotrif must not be used during pregnancy. It is not known whether afatinib passes into breast milk. Breastfeeding must be discontinued while taking Gilotrif and for 1 month after the final dose.

Use in Children:

The safety and efficacy of Gilotrif in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Gilotrif at Canada Pharmacy Online

Why is Gilotrif more affordable in Canada than in the United States?

Prescription drug prices, including Gilotrif, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Gilotrif I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Gilotrif per doctor's prescription.

Can I buy Gilotrif from you over the counter?

No, Gilotrif requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Gilotrif?

Yes, the generic afatinib dimaleate is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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