Inlyta (Axitinib)

Name: Inlyta
Brand: Pfizer
SKU: 6916
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Inlyta

Manufacturer: Pfizer

Country: Canada

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Inlyta

Manufacturer: Pfizer

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Generic Equivalent of Inlyta

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no generic product of Inlyta.

Inlyta Information

Inlyta at CanadaPharmacyOnline.com

The manufacturer of brand-name Inlyta (axitinib) is Pfizer Canada ULC. Inlyta is available at this pharmacy in 1 mg and 5 mg strengths from Canada and Turkey.

There is currently no generic equivalent available for Inlyta (at this pharmacy).

Dosage:

Inlyta (axitinib) is available in the following oral strengths at this pharmacy:
• Film-coated tablets: 1 mg and 5 mg.

Dosage is individualized and depends on tolerability. Swallow tablets whole with a glass of water. Maintain consistent dosing times.

Usage:

Inlyta (axitinib) is indicated for the treatment of advanced renal cell carcinoma (RCC, kidney cancer) after failure of one prior systemic therapy. Inlyta may be used as monotherapy or in combination with immunotherapy agents (such as pembrolizumab or avelumab) in certain settings, as determined by your oncologist. It works by targeting specific proteins involved in the growth of new blood vessels that tumors need to survive and grow.

Mechanism of Action
Axitinib, the active ingredient in Inlyta, selectively inhibits vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3). These receptors control the development of new blood vessels (angiogenesis), on which tumors depend for nutrients and oxygen to grow and spread. By blocking VEGFR signaling, axitinib cuts off the tumor’s blood supply, limiting its growth and metastasis. Renal cell carcinoma is particularly sensitive to VEGFR-targeted therapy because clear cell RCC frequently harbors mutations in the VHL gene, leading to overactivation of the VEGF signaling pathway.

Take Inlyta exactly as your oncologist prescribes, as directed in the Product Monograph. Take approximately every 12 hours. Do not stop or change your dose without consulting your oncologist.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Inlyta, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Inlyta (axitinib). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Inlyta; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Decreased appetite and weight loss
• Diarrhea
• Fatigue or weakness
• Hand-foot syndrome (palmar-plantar erythrodysaesthesia) — redness, pain, blistering, or sores on the palms and soles; a common side effect of VEGFR-targeted therapies
• High blood pressure (hypertension) — very common; blood pressure must be well controlled before and during treatment
• Hoarseness or voice changes
• Nausea or vomiting

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Arterial Thromboembolic Events: Chest pain, sudden weakness or numbness on one side, difficulty speaking, or sudden vision changes (signs of stroke or heart attack). Axitinib increases the risk of arterial blood clots.
• Bleeding or Hemorrhage: Coughing up blood, blood in urine or stool, unusual bruising, or uncontrolled bleeding.
• Gastrointestinal Perforation or Fistula: Sudden, severe abdominal pain. Rare but serious; may require surgery.
• Hepatotoxicity (Liver Toxicity): Jaundice, dark urine, right upper abdominal pain, or extreme fatigue. Liver function is monitored regularly during treatment.
• Hypertensive Crisis: Severe headache, blurred vision, or blood pressure that is very difficult to control. Hypertension must be managed proactively during axitinib treatment.
• Thyroid Dysfunction: Hypothyroidism (weight gain, fatigue, cold intolerance) or hyperthyroidism (weight loss, palpitations, anxiety) are common; thyroid function is monitored regularly.
• Wound Healing Complications: Axitinib must be discontinued at least 24 hours before elective surgery and restarted only after adequate wound healing.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Inlyta, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Inlyta/axitinib if:
• Allergies: Known hypersensitivity to axitinib or any ingredient in the tablet.

Tell your doctor about all of your medical conditions, past and present, before starting Inlyta. This is crucial as certain conditions affect the drug's safety.
• A history of blood clots.
• Bleeding disorders
• High blood pressure
• Liver disease
• Recent surgery
• Thyroid problems

Drug Interactions:

Before taking Inlyta, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information at https://labeling.pfizer.com/showlabeling.aspx?id=759.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Inlyta. Inlyta may interact with other medicines, including but not limited to:
• Antihypertensive drugs: Because axitinib commonly causes hypertension, you may be started on or require adjustment of blood pressure medications during treatment. Monitor blood pressure regularly.
• CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine, St. John's Wort) significantly reduce axitinib levels and effectiveness. Avoid strong CYP3A4 inducers; if unavoidable, the axitinib dose may need to be increased.
• CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, grapefruit juice) significantly raise axitinib levels and the risk of side effects. Avoid grapefruit juice. If a strong CYP3A4 inhibitor must be used, reduce the axitinib dose.

Pregnancy and Breastfeeding:

Inlyta can cause harm to an unborn baby. Women of childbearing potential must use highly effective contraception during treatment and for at least 1 week after the final dose. Inlyta must not be used during pregnancy. Male patients with female partners of childbearing potential should also use effective contraception. Breastfeeding must be discontinued while taking Inlyta. Discuss with your doctor.

Use in Children:

The safety and efficacy of Inlyta in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Inlyta at Canada Pharmacy Online

Why is Inlyta more affordable in Canada than in the United States?

Prescription drug prices, including Inlyta, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Inlyta I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Inlyta per your doctor’s prescription.

Can I buy Inlyta from you over the counter?

No, Inlyta requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Inlyta?

There is currently no generic equivalent available for Inlyta at this pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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