Iressa (Gefitinib)

Name: Iressa
Brand: Generic
SKU: 2726
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no brand product of Iressa.

Generic Equivalent of Iressa

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Gefitinib Tablet

Manufacturer: Generic

Country: Canada

Dosage: 250 mg

Qty-Price (USD):

Type:

Product: Gefitinib Tablet (Geftinat-Natco Pharm)

Manufacturer: Generic

Country: India

Dosage: 250 mg

Qty-Price (USD):

Iressa Information

Iressa and Gefitinib at CanadaPharmacyOnline.com

The manufacturer of the brand-name Iressa (gefitinib) was AstraZeneca. The brand Iressa is currently unavailable at this pharmacy.

Generic gefitinib tablets are produced by several reputable manufacturers that meet Health Canada's strict standards. The Canadian generic (Gefitinib Tablet) and an Indian generic (Geftinat, manufactured by Natco Pharma) are both available. The specific manufacturer of your dispensed medication may vary based on pharmacy inventory. Generic gefitinib tablets are sourced from manufacturers that meet applicable regulatory standards.

Important Information about Generic Gefitinib

Generic gefitinib contains the same active ingredient as brand-name Iressa. It must meet the same effectiveness and quality standards. This means it is designed to work like Iressa. Studies have shown that generic gefitinib is bioequivalent to brand-name Iressa, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit “Access to Generic Drugs in Canada | Canada.ca”.

Dosage:

Iressa (gefitinib) is available in the following oral strengths at this pharmacy:
• Tablets: 250 mg.

Dosage is individualized and based on your condition. The standard recommended adult dosage is 250 mg taken orally once daily, at approximately the same time each day. Do not stop treatment without consulting your oncologist.

Usage:

Iressa (gefitinib) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor indicated for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors harbor activating EGFR mutations. EGFR mutation testing must be performed before starting Iressa. It is specifically approved for patients with EGFR exon 19 deletions or the L858R substitution mutation. Iressa is ineffective in patients whose tumors do not harbor these specific mutations.

Mechanism of Action
Gefitinib selectively and reversibly inhibits the intracellular tyrosine kinase domain of the EGFR (epidermal growth factor receptor), also known as ErbB1. In lung cancers with activating EGFR mutations, the receptor is constitutively active, continuously driving cancer cell growth, survival, and spread. By blocking EGFR kinase activity, gefitinib disrupts these cancer-promoting signals, leading to cancer cell growth arrest and cell death. Because it is selective for the mutated EGFR found in cancer cells, gefitinib can be effective while causing less harm to normal cells compared to conventional chemotherapy.

Take Iressa exactly as your oncologist prescribes, as outlined in the Product Monograph. It may be taken with or without food. Take at the same time each day. If a dose is missed by more than 12 hours, skip the missed dose and take the next scheduled dose.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Iressa, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Iressa (gefitinib). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Iressa; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Acne-like skin rash (the most common side effect; usually occurs on the face, neck, chest, and back)
• Diarrhea
• Dry skin or itching
• Loss of appetite or nausea
• Mouth sores (stomatitis)
• Nail changes

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Eye Problems (Keratitis or Ulceration): Eye pain, redness, watering, changes in vision, or light sensitivity. Stop Iressa and seek urgent eye evaluation.
• Interstitial Lung Disease (ILD) / Pneumonitis: New or worsening shortness of breath, cough, or fever. ILD has occurred in about 1% of patients and can be fatal. Iressa must be stopped immediately if ILD is confirmed.
• Liver Toxicity: Jaundice, dark urine, or severe fatigue. Liver function is monitored periodically.
• Severe Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Severe Diarrhea or Dehydration: Persistent watery diarrhea or signs of dehydration. Contact your oncologist immediately.

Contraindications:

Do not take Iressa/gefitinib if:
• Allergies: Known hypersensitivity to gefitinib or any ingredient in the tablet.
• Breastfeeding

Tell your doctor about all of your medical conditions, past and present, before starting Iressa. This is crucial as certain conditions affect the drug's safety.
• Existing lung problems
• Eye conditions
• Kidney or liver disease

Drug Interactions:

Before taking Iressa, discuss all potential risks and interactions with your doctor or pharmacist. For complete information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00041427.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Iressa. Iressa may interact with other medicines, including but not limited to:
• CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine, St. John's Wort): Significantly reduce gefitinib levels and effectiveness; avoid concurrent use.
• CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, clarithromycin, ritonavir): May significantly increase gefitinib levels and the risk of toxicity.
• Proton pump inhibitors and H2 antagonists (e.g., ranitidine): Drugs that raise stomach pH reduce gefitinib absorption; separate by at least 6 hours if an H2 antagonist must be used.
• Warfarin: Gefitinib may increase warfarin's anticoagulant effect. Monitor INR closely.

Pregnancy and Breastfeeding:

Inform your doctor if you are pregnant or planning to become pregnant. Iressa can cause harm to an unborn baby. Women of childbearing potential must use effective contraception during treatment and for at least 1 month after the final dose. Iressa must not be used during pregnancy. Consult your doctor to weigh the benefits and risks of this medicine before using it while nursing. Breastfeeding is not recommended while taking Iressa; discuss with your doctor.

Use in Children:

The safety and efficacy of Iressa in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Iressa at Canada Pharmacy Online

Why is Iressa more affordable in Canada than in the United States?

Prescription drug prices, including Iressa, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Iressa I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Iressa per your doctor's prescription.

Can I buy Iressa from you over the counter?

No, Iressa requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Iressa?

Yes, the generic alternative, gefitinib, is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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