Kytril (Granisetron)

Name: Kytril
Brand: Roche Pharmaceuticals
SKU: 1550
Availability: InStock

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Qty-Price (USD)

Type:

Product: Kytril 5x3ml Vials

Manufacturer: Roche Pharmaceuticals

Country: Turkey

Dosage: 3 mg/3 ml

Qty-Price (USD):

Generic Equivalent of Kytril

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There is no generic product of Kytril.

Kytril Information

Kytril at CanadaPharmacyOnline.com

The manufacturer of brand-name Kytril is Roche Pharmaceuticals. It is available in many countries worldwide, including Turkey.

The generic granisetron is currently unavailable (at this pharmacy).

Dosage:

Kytril is available in the following strengths at this pharmacy:
• Injection: 3 mg/3 ml.

Kytril must be administered by a healthcare professional. For chemotherapy (CINV) prevention, the standard adult dose is 10 mcg/kg IV infused within 30 minutes before chemo. For post-operative (PONV) prevention, it is a fixed 1 mg IV push.

Usage:

Kytril (granisetron) is a selective serotonin 5-HT3 receptor antagonist (5-HT3 blocker) indicated for the prevention and treatment of nausea and vomiting induced by cytotoxic (cancer) chemotherapy and radiotherapy, and for the prevention and treatment of post-operative nausea and vomiting (PONV). Kytril does not treat nausea and vomiting after they are already severe. It is most effective when taken as a preventative measure before chemotherapy, radiotherapy, or surgery.

Mechanism of Action
Granisetron blocks serotonin (5-HT3) receptors, which are found in the vagal nerve terminals in the gut and in the vomiting center of the brain (the area postrema). During chemotherapy or radiotherapy, enterochromaffin cells in the gut release large amounts of serotonin, which activate 5-HT3 receptors and trigger the vomiting reflex. By selectively blocking these receptors, granisetron interrupts this reflex, preventing nausea and vomiting. It is particularly effective during the acute phase of CINV (within 24 hours of chemotherapy). It is often combined with NK1 receptor antagonists (such as aprepitant/Emend) and corticosteroids to provide comprehensive prevention of CINV.

Take Kytril exactly as your doctor prescribes, as outlined in the highlights of the prescribing information. You will receive the first dose before your chemotherapy or procedure as directed.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Kytril, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Kytril (granisetron). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Kytril; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Constipation
• Diarrhea
• Fatigue or weakness
• Headache (the most commonly reported side effect)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• QT Interval Prolongation: Palpitations, fainting, dizziness, or an irregular heartbeat. 5-HT3 antagonists, including granisetron, can prolong the QT interval, potentially causing serious cardiac arrhythmias such as Torsades de Pointes. Use with caution in patients with pre-existing cardiac conditions or those taking other QT-prolonging drugs.
• Serotonin Syndrome: Agitation, confusion, rapid heart rate, high blood pressure, muscle twitching, shivering, or diarrhea. This is a rare but potentially life-threatening condition that typically occurs when granisetron is combined with other serotonergic drugs.
• Severe Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.

Contraindications:

Do not take Kytril/granisetron if:
• Allergies: Known hypersensitivity to granisetron, other 5-HT3 antagonists, or any ingredient in the injection formulation.

Tell your doctor about all of your medical conditions, past and present, before starting Kytril. This is crucial as certain conditions affect the drug's safety.
• Electrolyte abnormalities (such as hypokalemia or hypomagnesemia)
• Heart conditions (including a history of QT prolongation, heart failure, or bradyarrhythmias)

Drug Interactions:

Before taking Kytril, discuss all potential risks and interactions with your doctor or pharmacist. For complete information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00025534.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Kytril. Kytril may interact with other medicines, including but not limited to:
• Drugs that prolong the QT interval: Additive risk of cardiac arrhythmias; monitor carefully.
• Serotonergic drugs (e.g., SSRIs, SNRIs, MAOIs, triptans, tramadol): Increased risk of serotonin syndrome.

Pregnancy and Breastfeeding:

Inform your doctor if you are pregnant or planning to become pregnant. Kytril should be used during pregnancy only if clearly necessary. Animal studies have not shown fetal harm, but human data are limited. Consult your doctor if you are pregnant. Consult your doctor to weigh the benefits and risks of this medicine before using it while nursing. It is not known whether granisetron passes into breast milk; discuss the risks and benefits of breastfeeding with your doctor.

Use in Children:

Granisetron injection is approved for pediatric patients aged 2 to 16 years for the prevention of chemotherapy-induced nausea, administered at a weight-based dose of 10 mcg/kg IV. Safety and effectiveness in pediatric patients under 2 years of age have not been established.

Frequently Asked Questions about Kytril at Canada Pharmacy Online

Why is Kytril more affordable in Canada than in the United States?

Prescription drug prices, including Kytril, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Kytril I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Kytril per prescription from your doctor.

Can I buy Kytril from you over the counter?

No, Kytril requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Kytril?

No, the generic alternative is currently unavailable (at this pharmacy).

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CanadaPharmacyOnline.com supplies only genuine Kytril from the UK and Turkey shipped using the UK and Turkish packaging. This Kytril is manufactured by Genetech Inc. (a member of Roche Group), the worldwide manufacturer of Kytril. This offer is neither endorsed nor authorized by Genetech Inc. (the United States and Canadian distributor of Kytril). CanadaPharmacyOnline.com has no affiliation whatsoever with Genetech Inc.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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