Litfulo (Ritlecitinib Tosylate)

Name: Litfulo
Brand: Pfizer
SKU: 7783
Availability: InStock

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Type:

Product: Litfulo Capsule (Limited Stock)

Manufacturer: Pfizer

Country: Canada

Dosage: 50 mg

Qty-Price (USD):

Generic Equivalent of Litfulo

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There is no generic product of Litfulo.

Litfulo Information

Litfulo at CanadaPharmacyOnline.com

The manufacturer of brand-name Litfulo is Pfizer. It is available in many countries worldwide, including Canada.

The generic ritlecitinib tosylate is currently unavailable (at this pharmacy).

Dosage:

Litfulo is available in the following oral strengths at this pharmacy:
• Capsules: 50 mg.

Dosage is individualized and based on your response to treatment. The standard recommended dosage is 50 mg taken orally once daily. Do not stop Litfulo without consulting your doctor, as hair regrowth may reverse after discontinuation.

Usage:

Litfulo (ritlecitinib) is a kinase inhibitor indicated for the treatment of severe alopecia areata in adults and adolescents aged 12 years and older. Alopecia areata is an autoimmune condition in which the immune system attacks hair follicles, causing hair loss on the scalp, face, and body. Litfulo is specifically approved for severe alopecia areata, defined as at least 50% scalp hair loss. Results vary; response is typically assessed after 24 weeks of treatment.

Mechanism of Action
Ritlecitinib is a selective, irreversible (covalent) inhibitor of JAK3 and TEC family kinases (including BTK, ITK, TXK, and RLK). In alopecia areata, T-cells attack hair follicles through a process driven by JAK3 and TEC kinase-dependent signaling pathways. By blocking JAK3, ritlecitinib interferes with cytokine signaling (including interleukin-2, interleukin-4, interleukin-7, interleukin-15, and interleukin-21) that activate these T-cells, reducing the autoimmune attack on hair follicles and allowing hair to regrow. Because ritlecitinib acts covalently (it binds irreversibly to its target), it may provide more sustained inhibition compared to reversible JAK inhibitors.

Take Litfulo exactly as your doctor prescribes, according to the highlights of prescribing information. Litfulo capsules should be swallowed whole each day, with or without food. Regular monitoring for infections and laboratory tests may be required during treatment.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Litfulo, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Litfulo (ritlecitinib). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Litfulo; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Acne or skin rash
• Blood count changes (decrease in platelets or lymphocytes)
• Headache
• Infections (upper respiratory tract infections, including the common cold)
• Mouth sores (stomatitis)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Herpes Zoster (Shingles) Reactivation: A painful blistering rash anywhere on the body. JAK inhibitors increase the risk of shingles. Vaccination is recommended before starting treatment if possible.
• Major Adverse Cardiovascular Events (MACE) and Malignancy: A class warning applies to JAK inhibitors. Increased risk of serious cardiovascular events (heart attack, stroke) and cancers (including lymphoma) has been observed with other JAK inhibitors in older patients with risk factors; monitor accordingly.
• Serious Infections: Fever, chills, productive cough, or other signs of a serious bacterial, fungal, or viral infection. Litfulo suppresses parts of the immune system, increasing the risk of infection. Tuberculosis screening is required before starting treatment.
• Severe Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.

Contraindications:

Do not take Litfulo/ritlecitinib if:
• Active serious infection, including active tuberculosis.
• Allergies: Known hypersensitivity to ritlecitinib or any ingredient in the capsule.

Tell your doctor about all of your medical conditions, past and present, before starting Litfulo. This is crucial as certain conditions affect the drug's safety.
• Any current or prior infections
• Cancer
• Diabetes
• History of cardiovascular disease
• If you smoke

Drug Interactions:

Before taking Litfulo, discuss all potential risks and interactions with your doctor or pharmacist. For complete information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00073579.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Litfulo. Litfulo may interact with other medicines, including but not limited to:
• CYP3A4 substrates: Litfulo may increase the concentration of other drugs and cause side effects.
• Immunosuppressants and biologics: Avoid concurrent use with strong immunosuppressants or biologics, as the combination may lead to excessive immune suppression and increased infection risk.
• Live vaccines: Must be avoided before and during Litfulo treatment. Non-live vaccines (including the shingles vaccine) should be given before starting, if possible.

Pregnancy and Breastfeeding:

Inform your doctor if you are pregnant or planning to become pregnant. Litfulo may cause harm to an unborn baby. Women of childbearing potential should use effective contraception during treatment and for 1 month after the final dose. Litfulo should not be used during pregnancy unless the benefits clearly outweigh the risks; discuss with your doctor. Consult your doctor to weigh the benefits and risks of this medicine before using it while nursing. It is not known whether ritlecitinib passes into breast milk; breastfeeding is not recommended while taking Litfulo. Discuss with your doctor.

Use in Children:

Litfulo is approved for use in adolescents 12 years of age and older for severe alopecia areata. The safety and efficacy in children under 12 have not been established.

Frequently Asked Questions about Litfulo at Canada Pharmacy Online

Why is Litfulo more affordable in Canada than in the United States?

Prescription drug prices, including Litfulo, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Litfulo capsules I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Litfulo per your doctor's prescription.

Can I buy Litfulo from you over the counter?

No, Litfulo requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Litfulo?

The generic alternative is currently unavailable (at this pharmacy).

Blog Post:

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Latest News:

Complete hair regrowth for some with alopecia after 3-year ritlecitinib treatment (news published on October 23, 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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