Lysodren (Mitotane)

Name: Lysodren
Brand: Medunik
SKU: 1651
Availability: InStock

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Type:

Product: Lysodren Tablet (Limited Supply)

Manufacturer: Medunik

Country: Canada

Dosage: 500 mg

Qty-Price (USD):

Generic Equivalent of Lysodren

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There is no generic product of Lysodren.

Lysodren Information

Lysodren at CanadaPharmacyOnline.com

The manufacturer of brand-name Lysodren (mitotane) is Medunik. It is available in many countries worldwide, including Canada.

The generic mitotane is currently unavailable (at this pharmacy).

Dosage:

Lysodren is available in the following oral strengths at this pharmacy:
• Tablets: 500 mg oral tablets.

Dosage is individualized and based on tolerability. The starting adult dose is 2000-6000 mg per day, taken in 3 or 4 divided doses. Your endocrinologist or oncologist will track mitotane concentrations through frequent blood draws. Doses are progressively escalated based on tolerability, with the goal of achieving a narrow therapeutic range for mitotane plasma concentration of 14 to 20 mg/L. Blood plasma levels exceeding 20 mg/L do not offer extra therapeutic benefit and are associated with a significantly higher incidence of severe central nervous system and brain toxicity.

Usage:

Lysodren (mitotane) is an adrenocortical suppressant indicated for the treatment of inoperable adrenal cortical carcinoma (cancer of the adrenal gland) and for Cushing's syndrome caused by adrenal carcinoma or adrenocortical tumors that cannot be removed surgically. Lysodren is an orphan drug used for rare conditions. It is one of the very few treatments specifically approved for adrenocortical carcinoma.

Mechanism of Action
Mitotane has a direct toxic effect on the adrenal cortex, causing selective destruction of the zona fasciculata and zona reticularis (the layers of the adrenal gland responsible for producing cortisol and sex steroids). At therapeutic doses, it can also cause atrophy of the outermost layer, the zona glomerulosa (which produces aldosterone). This reduces adrenal corticosteroid production and leads to cell death in both normal and malignant adrenocortical tissue. The precise mechanism is not fully understood, but mitotane appears to inhibit key steps in adrenal steroid synthesis and directly damage adrenal mitochondria. Because Lysodren suppresses the adrenal glands, adrenal insufficiency (a state in which the body cannot produce enough cortisol) is an expected and often intended therapeutic outcome. All patients on Lysodren require corticosteroid replacement therapy, and some may also require mineralocorticoid replacement (such as fludrocortisone) due to the total suppression of the adrenal cortex.

Take Lysodren exactly as your oncologist or endocrinologist prescribes, as outlined in the Product Monograph. Lysodren must be taken with food (a fatty meal helps absorption). Swallow the tablets whole. Do not crush or chew it. Caregivers should wear disposable gloves when administering Lysodren to prevent direct skin absorption. Regular monitoring of mitotane blood levels and adrenal function is required. Carry a medical alert card indicating that you are taking Lysodren and require additional corticosteroids in the event of physical stress or an emergency.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Lysodren, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Lysodren (mitotane). It is not an exhaustive list, and individual reactions can vary. Side effects are very common with Lysodren due to its mechanism of action, and most patients experience at least some adverse effects.

Common side effects: These are common side effects of Lysodren; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Diarrhea, nausea, and vomiting
• Dizziness, fatigue, and weakness
• Mental effects: depression, confusion, or difficulty concentrating
• Skin rash

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Adrenal Insufficiency (Adrenal Crisis): Severe fatigue, nausea and vomiting, abdominal pain, low blood pressure, or confusion. Adrenal crisis is a life-threatening emergency; seek emergency care immediately if suspected.
• Central Nervous System Toxicity: Severe lethargy, dizziness, slurred speech, difficulty walking, or confusion. High blood mitotane levels can cause significant neurological side effects.
• Liver Toxicity: Jaundice or elevated liver enzymes. Monitor liver function regularly.
• Severe Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.

Contraindications:

Do not take Lysodren/mitotane if:
• Allergies: Known hypersensitivity to mitotane or any ingredient in the tablet.
• Spironolactone: Using this drug can cause cancer therapy to fail.

Tell your doctor about all of your medical conditions, past and present, before starting Lysodren. This is crucial as certain conditions affect the drug's safety.
• Any ongoing infections
• Liver disease

Drug Interactions:

Before taking Lysodren, discuss all potential risks and interactions with your doctor or pharmacist. For complete information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00072625.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Lysodren. Lysodren may interact with other medicines, including but not limited to:
• Anticoagulants (warfarin): Mitotane significantly increases warfarin metabolism, reducing its effectiveness. INR must be monitored very closely, and the warfarin dose will likely need to be substantially increased.
• Corticosteroids (replacement therapy): All patients on Lysodren require corticosteroid replacement. Higher-than-normal doses of hydrocortisone or prednisolone are typically needed because mitotane also accelerates cortisol metabolism.
• CYP3A4 substrates: Mitotane is a potent CYP3A4 inducer and will reduce the blood levels of many other drugs metabolized by CYP3A4 (including many chemotherapy agents, antiretrovirals, and immunosuppressants). Review all concurrent medications with your oncologist.
• Spironolactone: Blocks the effects of mitotane and should be avoided during treatment.

Pregnancy and Breastfeeding:

Inform your doctor if you are pregnant or planning to become pregnant. Lysodren is contraindicated during pregnancy. Mitotane may cause fetal harm. Because mitotane accumulates deeply within body fat tissue and clears exceptionally slowly, women of childbearing potential must use effective contraception during treatment and after stopping Lysodren until blood plasma mitotane concentrations are completely undetectable and no longer measurable via blood testing (which can range from several months up to several years depending on individual tissue clearance rates). Men should also use contraception during treatment and for several months after stopping. Consult your doctor to weigh the benefits and risks of this medicine before using it while nursing. Breastfeeding must not be initiated or must be discontinued while taking Lysodren.

Use in Children:

Lysodren may be used in children and adolescents with adrenocortical carcinoma under close specialist supervision. Dosing is determined by a specialist based on body size and mitotane blood levels.

Frequently Asked Questions about Lysodren at Canada Pharmacy Online

Why is Lysodren more affordable in Canada than in the United States?

Prescription drug prices, including Lysodren, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Lysodren I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Mekinist per your doctor's prescription.

Can I buy Lysodren from you over the counter?

No, Lysodren requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Lysodren?

No, the generic alternative is currently unavailable (at this pharmacy).

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CanadaPharmacyOnline.com supplies only genuine Lysodren from Canada shipped using Canadian packaging. This Lysodren is manufactured by Bristol-Myers Squibb the worldwide manufacturer of Lysodren. This offer is neither endorsed nor authorized by Bristol-Myers Squibb (the United States and Canadian distributor of Lysodren). CanadaPharmacyOnline.com has no affiliation whatsoever with Bristol-Myers Squibb.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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