Nexavar (Sorafenib)

Name: Nexavar
Brand: Bayer
SKU: 6819
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Nexavar

Manufacturer: Bayer

Country: Canada

Dosage: 200 mg

Qty-Price (USD):

Generic Equivalent of Nexavar

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Sorafenib

Manufacturer: Generic

Country: India

Dosage: 200 mg

Qty-Price (USD):

Nexavar Information

Nexavar and Sorafenib at CanadaPharmacyOnline.com

The manufacturer of brand-name Nexavar (sorafenib tosylate) is Bayer. It is available in many countries worldwide, including Canada.

The generic sorafenib is produced by several reputable manufacturers that meet the strict standards of Health Canada. Common generic producers include Natco Pharma. The specific manufacturer of the medication dispensed may vary based on pharmacy inventory. Generic sorafenib is sourced from manufacturers that meet applicable regulatory standards.

Important Information about Generic Sorafenib

Generic sorafenib contains the same active ingredient as brand-name Nexavar. It must meet the same effectiveness and quality standards. This means it is designed to work like Nexavar. Studies have shown that generic sorafenib is bioequivalent to brand-name Nexavar, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit “Access to Generic Drugs in Canada | Canada.ca”.

Dosage:

Nexavar (sorafenib tosylate) is available in the following oral strengths at this pharmacy:
• Film-coated tablets: 200 mg.

Dosage is individualized. The standard recommended adult dose is 400 mg (two 200 mg tablets) taken twice daily (800 mg total per day), approximately 12 hours apart, unless otherwise directed by your oncologist. Do not stop Nexavar without consulting your oncologist.

Usage:

Nexavar (sorafenib) is a multi-kinase inhibitor indicated for the treatment of unresectable hepatocellular carcinoma (HCC, liver cancer), advanced renal cell carcinoma (RCC, kidney cancer) after prior interferon-alpha or interleukin-2-based therapy, or in patients for whom such therapy is not considered appropriate. It is also used to treat locally recurrent or metastatic, progressive, differentiated thyroid carcinoma that is refractory to radioactive iodine treatment.

Mechanism of Action
Sorafenib inhibits multiple kinases simultaneously. Its anti-tumor effects are mediated through two main actions. First, it inhibits tumor cell proliferation by blocking RAF kinases (including CRAF and BRAF), which are key components of the RAF-MEK-ERK signaling pathway that drives cancer cell division. Second, it inhibits tumor angiogenesis (new blood vessel formation) by blocking vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3) and platelet-derived growth factor receptor beta (PDGFR-β), which are essential for tumor blood supply. By simultaneously targeting tumor cell proliferation and tumor blood supply, sorafenib acts through dual mechanisms.

Take Nexavar exactly as your oncologist prescribes, as outlined in the Product Monograph. Take Nexavar without food (at least 1 hour before or 2 hours after a meal). Alternatively, you may take it with a light, low- to moderate-fat meal. You must avoid high-fat meals, as high-fat intake can significantly reduce the drug's absorption and diminish its effectiveness.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Nexavar, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Nexavar (sorafenib). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Nexavar; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Diarrhea
• Fatigue
• Hair loss or thinning
• Hand-foot skin reaction — redness, swelling, blistering, or pain on the palms and soles
• High blood pressure
• Nausea or loss of appetite
• Skin rash or skin dryness and itching

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Bleeding: Coughing up blood, blood in urine or stool, or sudden severe headache. Sorafenib increases the risk of bleeding, particularly in patients with HCC who may already have a bleeding risk due to cirrhosis.
• Cardiac Ischemia or Infarction: Chest pain, shortness of breath, or arm or jaw pain. Sorafenib has been associated with an increased risk of heart attack.
• Hypertensive Crisis: Very high blood pressure. Blood pressure must be monitored and controlled throughout treatment.
• QT Interval Prolongation: Palpitations or fainting. Sorafenib can prolong the QT interval; monitor ECG and electrolytes during treatment.
• Severe Liver Toxicity (Drug-Induced Hepatitis): Jaundice, dark urine, or right upper abdominal pain. Monitor liver function regularly.
• Severe Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Wound Healing Impairment: Sorafenib must be stopped at least 10 days before elective surgery and may not be restarted until adequate wound healing has occurred.

Contraindications:

Do not take Nexavar/sorafenib if:
• Allergies: Known hypersensitivity to sorafenib tosylate or any ingredient in the tablet.
• Concurrent carboplatin and paclitaxel in squamous cell lung cancer

Tell your doctor about all of your medical conditions, past and present, before starting Nexavar. This is crucial as certain conditions affect the drug's safety.
• A history of blood clots.
• Bleeding disorders
• Heart disease
• High blood pressure
• Liver disease
• Recent surgery

Drug Interactions:

Before taking Nexavar, discuss all potential risks and interactions with your doctor or pharmacist. For complete information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00080756.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Nexavar. Nexavar may interact with other medicines, including but not limited to:
• CYP3A4 inducers (e.g., rifampicin, St. John's Wort, carbamazepine, phenytoin): Significantly reduce sorafenib levels; avoid concurrent use.
• Drugs that prolong the QT interval: Additive risk of cardiac arrhythmias; use with caution.
• High-fat meals: Reduce sorafenib bioavailability by up to 29%; take on an empty stomach or with a low- to moderate-fat meal.
• Warfarin: Sorafenib may increase the risk of bleeding and affect INR when taken with warfarin. Monitor INR closely.

Pregnancy and Breastfeeding:

Inform your doctor if you are pregnant or planning to become pregnant. Nexavar can cause harm to an unborn baby. Women of childbearing potential must use effective contraception during treatment and for at least 6 months after the final dose. Nexavar must not be used during pregnancy. Consult your doctor to weigh the benefits and risks of this medicine before using it while nursing. Breastfeeding must be discontinued while taking Nexavar and for at least 2 weeks after the final dose. Discuss with your doctor.

Use in Children:

The safety and efficacy of Nexavar in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Nexavar at Canada Pharmacy Online

Why is Nexavar more affordable in Canada than in the United States?

Prescription drug prices, including Nexavar, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Nexavar I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Nexavar per prescription from your doctor.

Can I buy Nexavar from you over the counter?

No, Nexavar requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Nexavar?

Yes, the generic alternative, sorafenib, is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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