Otezla (Apremilast)

Name: Otezla
Brand: Amgen
SKU: 7001
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Otezla

Manufacturer: Amgen

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Generic Equivalent of Otezla

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Apremilast Starter Kit (4 tabs/4 tabs/19 tabs)

Manufacturer: Generic

Country: Canada

Dosage: 10 mg/20 mg/30 mg

Qty-Price (USD):

Type:

Product: Apremilast

Manufacturer: Generic

Country: India

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Apremilast

Manufacturer: Generic

Country: India

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Apremilast (Expiry Note)

Manufacturer: Generic

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Otezla Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on April 30, 2025.

Otezla and Apremilast at CanadaPharmacyOnline.com

Brand Otezla (apremilast), originally developed by Celgene and now marketed by Amgen, is available in many countries worldwide, including Canada.

Generic apremilast is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Apremilast:

Generic apremilast contains the same active ingredient as brand-name Otezla and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Otezla. Studies have demonstrated bioequivalence between generic and brand-name apremilast, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. Talk to your doctor or pharmacist, if you have any questions about using generic apremilast.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs

Dosage:

Brand Otezla is available in 30 mg oral tablets.

Generic apremilast is available in dosages comparable to brand-name Otezla and typically includes a starter pack for the initial titration. The starter pack usually contains tablets of 10 mg and 20 mg to be taken over the first few days, gradually leading up to the maintenance dose of 30 mg once daily. Individual tablet strengths of 30 mg are also available for ongoing maintenance therapy. The specific tablet counts in starter kits may vary.

Your doctor will determine the appropriate dose and titration schedule based on your individual needs and medical conditions.

Usage:

Otezla (apremilast) is a prescription medication used to treat moderate to severe plaque psoriasis in adult patients who are candidates for light therapy (phototherapy) or systemic therapy (medications that affect the whole body), active psoriatic arthritis and oral ulcers associated with Behcet's Disease in adults. Otezla is also used to treat pediatric patients over six years of age and weighing at least 20 kg with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy. (source: the product labeling information)

Mechanism of Action
Otezla (apremilast) belongs to a class of drugs called phosphodiesterase 4 (PDE4) inhibitors. The PDE4 enzyme is involved in inflammation that causes swollen and tender joints and skin symptoms such as scalp and nail psoriasis. Otezla works by reducing inflammation in the body, which helps alleviate symptoms of these conditions.

Take Otezla exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Otezla, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Otezla, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects – The following are some common side effects of Otezla, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning or if you experience any other concerning symptoms.
• Abdominal pain (upper or lower);
• Back pain;
• Diarrhea (most frequently reported side effect and can be severe);
• Dyspepsia (indigestion);
• Fatigue;
• Frequent bowel movements;
• Headache (frequently reported side effect);
• Insomnia (difficulty sleeping);
• Nausea (feeling sick to your stomach, very common);
• Tension headache;
• Upper respiratory tract infections (including common cold, sinus infection, and sore throat);
• Vomiting;
• Weight loss (a notable side effect for some patients)

Serious side effects- Stop taking Otezla and seek immediate medical attention if you experience any of the following:
• A severe allergic reaction (hives, difficulty breathing, severe dizziness, swelling of the face, lips, or tongue);
• Depression and suicidal thoughts or behavior (Otezla may increase your risk of depression and suicidal ideation - patients with a history of depression may be at a higher risk);
• Significant unexplained weight loss (rapid or significant unexplained weight loss can be a concern and should be evaluated by a doctor);
• Severe diarrhea, nausea, and vomiting (severe and persistent diarrhea, nausea, or vomiting can lead to dehydration, electrolyte imbalances, and other complications);
• Worsening of existing conditions (Otezla might worsen certain pre-existing conditions)

Contraindications:

The following is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist before starting Otezla.

Otezla should not be used if:
• You are allergic to apremilast or any of the inactive ingredients in this medication.

Tell your doctor about your medical conditions, past and present, before starting Otezla. It’s crucial because certain conditions may affect whether Otezla is right for you. These conditions may include, but are not limited to:
• History of depression or suicidal ideation (Otezla has been associated with an increased risk of depression and suicidal thoughts of behavior)

Drug Interactions:

Before taking Otezla, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the official Otezla prescribing information (package insert): https://www.amgen.ca/-/media/Themes/CorporateAffairs/amgen-ca/amgen-ca/documents/products/en/otezla_pm.pdf

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Otezla can interact with many medications, including (but not limited to): strong CYP3A4 inducers (e.g., rifampin, phenobarbital, carbamazepine, phenytoin, St. John's Wort). These medications can significantly decrease the concentration of apremilast, potentially reducing its effectiveness. Concomitant use with strong CYP3A4 inducers is generally not recommended.

Pregnancy and Breastfeeding

The safety of Otezla during pregnancy and breastfeeding has not been fully established. It should only be used if the potential benefit outweighs the potential risk to the fetus or infant. Women of childbearing potential are advised to use effective contraception during treatment.

Frequently Asked Questions about Otezla at Canada Pharmacy Online:

Why is Otezla more affordable in Canada than in the United States?

Prescription drug prices, including Otezla, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can the Otezla tablet be split or crushed?

Do not crush, chew, or split Otezla tablets. Swallow the tablet whole with water. Crushing, chewing, or splitting the tablets may affect how the medication works. Consult your doctor or pharmacist if you have difficulty swallowing the tablet.

What is the difference between Otezla 20 mg and 30 mg?

The difference in dosage represents the amount of active ingredient(s) present in the drug.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Otezla tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Otezla at once, per your doctor's prescription.

Can I buy Otezla over the counter from you?

No, Otezla requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Otezla?

Yes, there is a generic alternative for this product called apremilast.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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