Premarin Vaginal Cream (Conjugated Estrogens)

Name: Premarin Vaginal Cream
Brand: Wyeth
SKU: 2323
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Premarin Vaginal Cream

Manufacturer: Wyeth

Country: India

Dosage: 14 gm

Qty-Price (USD):

Type:

Product: Premarin Vaginal Cream (Expiry Promo)

Manufacturer: Pfizer

Country: Canada

Dosage: 30 gm

Qty-Price (USD):

Generic Equivalent of Premarin Vaginal Cream

Type

Product

Manufacturer

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Qty-Price (USD)

There is no generic product of Premarin Vaginal Cream.

Premarin Vaginal Cream online Canadian Pharmacy

Premarin Vaginal Cream Information

medically reviewed by Carol Hou (BSc. Pharm) on July 1, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Premarin Vaginal Cream at CanadaPharmacyOnline.com

Brand name Premarin vaginal cream is marketed and distributed by Pfizer in Canada. It is also manufactured by Wyeth (a subsidiary of Pfizer) in India.

A generic version of Premarin Vaginal Cream is currently unavailable (at this pharmacy).

Dosage:

Premarin is a vaginal cream, a semi-solid preparation specifically designed for intravaginal application. It is available in one strength: 0.625 mg of conjugated estrogens per gram of cream. Typically, it comes in 14 gm and 30 gm tube sizes.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Premarin vaginal cream, containing conjugated estrogens, is a prescription medication primarily used to treat symptoms stemming from decreased estrogen levels, commonly experienced during perimenopause and post-menopause. It can also be used in other conditions causing low estrogen, such as after oophorectomy or certain cancer treatments. Its primary uses include alleviating vaginal dryness, itching, and burning, treating moderate to severe painful intercourse (dyspareunia), and managing vulvar and vaginal atrophy (VVA), also known as atrophic vaginitis. VVA is a common condition characterized by dryness, itching, and shrinkage of the vulval and vaginal tissues, which can lead to significant discomfort and changes in tissue appearance. By locally replacing estrogen, it restores vaginal tissue health and elasticity, thereby reducing these symptoms.

Mechanism of Action:
Premarin vaginal cream treats menopausal vaginal atrophy by replacing diminished estrogen directly in the vaginal tissues. Its conjugated estrogens bind to local receptors, which restores tissue health by increasing blood flow, promoting cell growth, and improving lubrication and pH balance. This targeted action effectively relieves symptoms like dryness, discomfort, and painful intercourse with minimal systemic absorption.

Use Premarin vaginal cream exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before using Premarin vaginal cream, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Premarin vaginal cream (conjugated estrogens). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Premarin vaginal cream, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Back pain.
• Breast pain or tenderness: This can also include breast enlargement.
• Changes in vaginal discharge.
• Fluid retention (edema).
• Hair loss.
• Headache: This is a very common side effect.
• Irregular vaginal bleeding or spotting.
• Pelvic pain.
• Stomach/abdominal issues: Cramps, bloating, nausea, and vomiting.
• Vaginal reactions: Burning, irritation, itching, or increased discharge at the application site.
• Vaginal yeast infection.

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Blood clots: Symptoms can include pain, swelling, warmth, redness in an arm or leg, sudden shortness of breath, sharp chest pain (especially with breathing), or coughing up blood (signs of a blood clot in the lungs).
• Certain cancers:
o Breast cancer: New breast lumps, changes in breast size/shape/texture/temperature, or nipple discharge.
o Cancer of the uterus (endometrial cancer): Report any unusual vaginal bleeding immediately, especially after menopause. o Ovarian cancer.
• Dementia: While primarily observed with systemic estrogen therapy in women 65 years of age or older, symptoms may include memory problems, confusion, difficulty with familiar tasks, or personality changes. The systemic absorption from Premarin vaginal cream is generally minimal, and a direct link to increased dementia risk with localized use has not been definitively established.
• Enlargement of benign uterine tumors (fibroids).
• Gallbladder disease: Severe upper right abdominal pain, nausea, vomiting, fever, or clay-colored stools.
• Heart attack: Chest pain or pressure, pain spreading to your arm, back, neck, or jaw, unusual sweating, nausea, or lightheadedness.
• High blood pressure.
• High blood sugar.
• Liver problems: Yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, loss of appetite.
• Severe allergic reactions: Rash, itching, hives, swelling of the face, lips, tongue, or throat, or trouble breathing.
• Stroke: Sudden severe headache, slurred speech or trouble understanding speech, changes in vision, sudden weakness or numbness on one side of the body, dizziness, or fainting.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Premarin vaginal cream, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Premarin Vaginal Cream should not be used if you:
• Are allergic to conjugated estrogens (the active ingredient in Premarin) or any other ingredient.
• Are pregnant: Premarin vaginal cream is not for use during pregnancy and can cause harm to the fetus.
• Have an established diagnosis of dementia: For patients with an established diagnosis of dementia, the use of Premarin vaginal cream should be carefully considered by your doctor. While systemic estrogen therapy has been associated with an increased risk of probable dementia in women aged 65 years or older, the systemic absorption from localized vaginal estrogen therapy like Premarin vaginal cream is minimal, and this risk is generally not considered to apply to localized use. Your doctor will assess your individual medical history and the potential benefits versus risks.

Tell your doctor about all of your medical conditions, past and present, before starting Premarin vaginal cream This is crucial because certain conditions can affect whether Premarin vaginal cream is right for you. These conditions may include, but are not limited to:
• Asthma or epilepsy: Estrogen can sometimes exacerbate these conditions.
• Blood clots (DVT, PE, history of thrombophilic disorders): Estrogen significantly increases the risk of blood clots. This is a significant warning.
• Bone disease (affecting calcium/phosphorus): Estrogen can influence calcium levels.
• Cancer (breast, uterine, estrogen-dependent, family history of breast cancer, history of breast lumps/biopsies/abnormal mammograms): Estrogen can stimulate the growth of certain cancers, particularly breast and uterine cancers. Careful consideration and monitoring are essential.
• Eye problems (loss of vision due to blood vessel disease): This is a rarer but serious potential side effect.
• Gallbladder disease: Estrogen can increase the risk of gallbladder disease.
• Heart problems (heart attack, stroke, coronary heart disease, high blood pressure, high cholesterol/triglycerides): Estrogen can impact cardiovascular health, and these conditions increase the risk of serious cardiovascular events.
• Kidney disease: This can affect how the body processes medications.
• Liver problems: The liver metabolizes hormones, so liver dysfunction can affect how the body handles estrogen.
• Migraine headaches (especially with aura): Hormonal changes can influence migraines, and migraines with aura are sometimes associated with an increased stroke risk, which estrogen can further elevate.
• Over 65 years of age: While systemic estrogen therapy may carry an increased risk of dementia in women over 65, this risk is generally not associated with localized vaginal estrogen therapy due to minimal systemic absorption. However, as with any medication, a thorough medical evaluation and discussion with your doctor are essential to assess individual risks and benefits, especially in older adults.
• Porphyria: Certain medications, including estrogens, can trigger attacks in individuals with porphyria.
• Presence of an intact uterus: Unlike systemic estrogen therapy, localized vaginal estrogen therapy like Premarin vaginal cream generally does not require co-administration of progestin to protect the endometrium from hyperplasia due to minimal systemic absorption. Discuss this with your doctor.
• Unusual vaginal bleeding: This is a red flag that requires immediate investigation to rule out severe conditions like uterine cancer.
• Uterine fibroids or endometriosis: Estrogen can cause these conditions to worsen or enlarge.

Contraception
Premarin vaginal cream contains mineral oil, which may weaken latex condoms, diaphragms, and cervical caps. Therefore, these methods may not be effective in preventing pregnancy or protecting against STIs. It is recommended to avoid using these barrier methods for at least 72 hours after applying Premarin vaginal cream. Premarin vaginal cream is not a contraceptive. If you require contraception, consult your doctor about alternative birth control options and STI protection while you are using Premarin.

Smoking
Smoking significantly increases the risk of serious cardiovascular side effects when combined with systemic estrogen therapy. While the systemic absorption from Premarin vaginal cream is minimal, avoiding smoking is always recommended for overall health.

Drug Interactions:

Before taking Premarin vaginal cream, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the complete prescribing information for Premarin vaginal cream: https://labeling.pfizer.com/showlabeling.aspx?id=132.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Premarin vaginal cream may interact with other medicines but is not limited to:

Inducers of CYP3A4 (May decrease estrogen levels and effectiveness):
These substances can speed up the metabolism of estrogens, potentially making Premarin less effective.
• Certain Anti-epileptic medications, Such as carbamazepine (Tegretol, Carbatrol) and phenobarbital.
• Rifampin (an antibiotic): Used to treat infections like tuberculosis.
• St. John's Wort (herbal supplement): Can cause your body to clear estrogen medications faster, leading to worsened or returning menopause symptoms.

Inhibitors of CYP3A4 (May increase estrogen levels and side effects):
These substances can slow the metabolism of estrogens, potentially increasing Premarin levels in your body and leading to more side effects.
• Certain Antifungal medications include ketoconazole and itraconazole (Sporanox, Tolsura).
• Certain Macrolide antibiotics: Such as erythromycin (Ery-Tab) and clarithromycin.
• Ritonavir (antiviral medication): Used to treat HIV. As a strong CYP3A4 inhibitor, ritonavir may increase estrogen levels, potentially leading to more side effects. The full clinical impact of this interaction should be discussed with your doctor.

Other potential interactions:
• Blood thinners (anticoagulants, e.g., warfarin): While systemic estrogen can alter the effects of certain blood thinners, the systemic absorption from Premarin vaginal cream is generally minimal, and therefore, the impact on blood clotting parameters is typically less pronounced. Nevertheless, close monitoring by your doctor is recommended if you use blood thinners concurrently.
• Insulin or oral diabetes medicine: Premarin can affect blood sugar levels.
• Thyroid medications: Estrogen use may change the amount of thyroid medication needed.

Frequently Asked Questions about Premarin Vaginal Cream at Canada Pharmacy Online:

Why is Premarin vaginal cream more affordable in Canada than in the United States?

Prescription drug prices, including Premarin vaginal cream, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tubes I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Premarin vaginal cream at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Premarin vaginal cream requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

How is Premarin Vaginal Cream applied?

It comes with a special applicator to help measure and apply the cream directly into the vagina.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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