Simbrinza (Brinzolamide/Brimonidine Tartrate Ophthalmic Suspension)

Name: Simbrinza
Brand: Alcon
SKU: 7004
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Simbrinza

Manufacturer: Alcon

Country: Canada

Dosage: 1 %/0.2 %/10 ml

Qty-Price (USD):

Type:

Product: Simbrinza

Manufacturer: Alcon

Country: India

Dosage: 1 %/0.2 %/5 ml

Qty-Price (USD):

Generic Equivalent of Simbrinza

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Brinzolamide/Brimonidine Tartrate Ophthalmic Suspension

Manufacturer: Generic

Country: India

Dosage: 1 %/0.2 %/5 ml

Qty-Price (USD):

Simbrinza Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on June 12, 2025.

Simbrinza and Brinzolamide/Brimonidine Tartrate Ophthalmic Suspension at CanadaPharmacyOnline.com

Brand Simbrinza, manufactured by Alcon, is available in Canada and India.

Generic brinzolamide/brimonidine tartrate ophthalmic suspension is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Brinzolamide/Brimonidine Tartrate Ophthalmic:

Generic brinzolamide/brimonidine tartrate ophthalmic suspension contains the same active ingredient as brand-name Simbrinza. It is required to meet the same safety, effectiveness, and quality standards as the brand-name product. Generic medications are bioequivalent to their brand-name counterparts, meaning they are absorbed and perform similarly in the body. However, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have questions about using generic brinzolamide/brimonidine tartrate ophthalmic suspension.

For information about generic drug approval and bioequivalence, please visit What Makes a Generic the Same as a Brand-Name Drug? - FDA.

Dosage:

Simbrinza (Brinzolamide/Brimonidine Tartrate) is an ophthalmic suspension (eye drops) commonly available in the strength of 1%/0.2%. It is typically supplied in 5 ml and 10 ml bottles.

Your doctor will determine the appropriate dose and treatment duration based on your needs and medical condition.

Usage:

Brand Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) is a prescription medication used to treat conditions like open-angle glaucoma and ocular hypertension, where elevated eye pressure can damage the optic nerve and potentially lead to vision loss.

For more information, refer to the product labelling information: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204251s000lbl.pdf.

Mechanism of Action:
Combining two actions, Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) lowers eye pressure. One part of the medicine, brinzolamide, reduces the fluid your eye makes. The other part, brimonidine tartrate, also decreases fluid production and helps improve fluid drainage from your eye through a different pathway. By performing both functions, Simbrinza offers a more comprehensive way to control elevated eye pressure, which is vital for protecting your vision in conditions like glaucoma.

Use Simbranza exactly as your doctor prescribes. Do not change your dosage or stop using the medication without consulting your doctor. Follow the instructions in the Highlights of Prescribing Information | Novartis US. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Simbranza, it is essential to discuss all possible aspects with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Simbrinza, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects: These are examples of some common side effects of Simbrinza, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Blurred vision (often temporary)
• Changes in taste (dysgeusia)
• Dry mouth
• Eye irritation (burning, stinging, foreign body sensation)
• Red eyes (ocular hyperemia)

Serious or rare side effects: Stop taking Simbrinza and seek immediate medical attention if you experience any of the following:
• Acid-Base Imbalance: While topical use minimizes systemic absorption, some individuals might rarely experience a systemic acid-base imbalance (e.g., metabolic acidosis), particularly if they have kidney problems.
• Blood Disorders: As brinzolamide is a sulfonamide, very rare but serious blood disorders (like aplastic anemia or agranulocytosis) can occur. Symptoms might include unusual tiredness, easy bruising, or signs of infection.
• Cardiovascular Effects: Simbrinza, particularly due to the brimonidine component, can rarely cause changes in heart rate or blood pressure, including slowed or irregular heartbeat, or significant drops in blood pressure (which might cause dizziness or fainting).
• Central Nervous System Effects (especially in young children): In very rare cases, especially if inadvertently given to infants or very young children (under 2 years old, for whom it's contraindicated), brimonidine can cause severe drowsiness, decreased alertness, low body temperature, low blood pressure, slowed breathing, or even coma.
• Serious Eye Reactions: While mild eye irritation is common, severe or worsening eye pain, persistent redness, swelling, or signs of infection (discharge, crusting) should be promptly evaluated.
• Severe Allergic Reactions: Though uncommon, these can manifest as hives, swelling of the face, lips, tongue, or throat, severe skin rash (including blistering or peeling skin, like Stevens-Johnson syndrome), or difficulty breathing.

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist before starting Simbrinza.

Simbrinza should not be used if:
• Known allergy or severe hypersensitivity reaction to brinzolamide, brimonidine tartrate, any other ingredients in the Simbrinza formulation, or sulfonamides.
• You have a child younger than 2 years of age (strictly contraindicated due to severe CNS depression risk).
• You are currently taking antidepressants that affect noradrenergic transmission (such as tricyclic antidepressants and mianserin)
• You are currently taking monoamine oxidase (MAO) inhibitors.
• You have severe kidney problems (severe renal impairment, creatinine clearance less than 30 mL/min) or hyperchloraemic acidosis.

Tell your doctor about all your medical conditions, past and present, before starting Simbrinza. This is crucial because certain conditions can affect whether Simbrinza is right for you. These conditions may include, but are not limited to:
• Blood Disorders: As brinzolamide is a sulfonamide, very rare but serious blood disorders (like aplastic anemia or agranulocytosis) can occur. Symptoms might include unusual tiredness, easy bruising, or signs of infection.
• Severe Kidney Problems: It should not be used in patients with severe renal impairment (creatinine clearance less than 30 mL/min) or hyperchloraemic acidosis (a condition where your blood becomes too acidic), as the brinzolamide component is primarily excreted by the kidneys.

Drug Interactions:

Before taking Simbrinza, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Simbrinza product monograph in Canada.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Simbrinza may interact with other medicines such as:
• Antidepressants Affecting Noradrenergic Transmission: Patients on antidepressants that affect noradrenergic transmission (such as tricyclic antidepressants and mianserin) should also not use Simbrinza. These medications can interfere with the effects of brimonidine.
• Antihypertensives and Cardiac Glycosides: The brimonidine component of Simbrinza can lower blood pressure. Therefore, caution is advised when using Simbrinza with medications for high blood pressure (antihypertensives) or drugs for heart failure (cardiac glycosides like digoxin), as it may lead to an additive hypotensive effect.
• Central Nervous System (CNS) Depressants: Due to the brimonidine component, Simbrinza can cause drowsiness and fatigue. Concurrent use with other CNS depressants (such as alcohol, opioids, barbiturates, sedatives, or anesthetics) can lead to an additive or potentiating effect, increasing drowsiness and other CNS side effects.
• High-Dose Salicylates: While rare with topical use, high-dose salicylate therapy (like high-dose aspirin) in conjunction with carbonic anhydrase inhibitors like brinzolamide could potentially lead to acid-base and electrolyte alterations or even neurotoxicity.
• Monoamine Oxidase (MAO) Inhibitors and Tricyclic Antidepressants: These are significant interactions. MAO inhibitors (like isocarboxazid, phenelzine, tranylcypromine, linezolid) and certain tricyclic antidepressants (like amitriptyline, nortriptyline, clomipramine, mianserin) can interfere with the metabolism of brimonidine, potentially leading to increased systemic side effects such as a significant drop in blood pressure. Simbrinza is generally contraindicated in patients taking these medications.
• Oral Carbonic Anhydrase Inhibitors: Brinzolamide is a topical carbonic anhydrase inhibitor that is absorbed systemically. Combining Simbrinza with oral carbonic anhydrase inhibitors (like acetazolamide or methazolamide) is not recommended. This can lead to an additive systemic effect of carbonic anhydrase inhibition, potentially causing acid-base or electrolyte imbalances.
• Other Eye Medications: If you are using other eye drops to lower intraocular pressure, they should be administered at least five minutes apart from Simbrinza to ensure proper absorption and effectiveness of each medication.

Pregnancy and Breastfeeding:

If you are pregnant, planning to become pregnant, or breastfeeding, it is crucial to speak with your doctor about Simbrinza. While there isn’t extensive human data on its use during pregnancy, Simbrinza is generally NOT recommended, as its components may cross the placenta and potentially affect the developing baby. Similarly, because the medications in Simbrinza can pass into breast milk and potentially cause serious side effects in a nursing infant, it is generally not recommended during breastfeeding. Discuss the potential risks and benefits with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Use in Children:

Simbrinza is not safe and should never be given to infants under 2 years of age due to a significant risk of side effects like extreme drowsiness, low blood pressure, or slowed breathing. For children and adolescents aged 2 to 17, Simbrinza is generally not recommended because its safety and effectiveness haven't been fully studied in this age group, and there's still a concern for similar side effects, though less severe than in infants. Always consult your child's eye doctor for the most appropriate and safest treatment for their eye condition.

Frequently Asked Questions about Simbrinza at CanadaPharmacyOnline.com:

Why is Simbrinza more affordable in Canada than the United States?

Prescription drug prices, including Simbrinza, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can I buy over the counter from you?

No, Simbrinza requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Simbrinza eye drops I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Simbrinza at one time, as per your doctor's prescription.

Does Simbrinza make you drowsy?

Simbrinza may cause drowsiness in some patients. Use caution when driving, operating machinery, or performing other dangerous activities. Stop using this medication and call your doctor right away if you have blurred or tunnel vision, eye pain, see halos around lights, eye redness, or severe discomfort.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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