Durezol (Difluprednate)

Name: Durezol
Brand: Novartis
SKU: 6860
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Durezol Ophthalmic Emulsion

Manufacturer: Novartis

Country: Canada

Dosage: 0.05 %/5 ml

Qty-Price (USD):

Generic Equivalent of Durezol

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Difluprednate Eye Drops

Manufacturer: Generic

Country: India

Dosage: 0.05 %/5 ml

Qty-Price (USD):

Durezol Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on July 24, 2025.

Durezol and Difluprednate at CanadaPharmacyOnline.com

Brand Durezol, manufactured by Novartis, is available in many countries worldwide, including Canada.

Generic difluprednate is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Difluprednate:

Generic difluprednate contains the same active ingredient as brand-name Durezol and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Durezol. Studies have demonstrated bioequivalence between generic and brand-name difluprednate, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic difluprednate, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs

Dosage:

Durezol, and its generic counterpart, difluprednate, are both available as a 0.05% ophthalmic emulsion (eye drops), typically supplied in a 5 mL bottle.

Your doctor will determine the appropriate dosage based on your individual needs and medical conditions.

Usage:

Durezol (difluprednate) is a prescription medication used to reduce inflammation and pain after ocular surgery and to treat endogenous anterior uveitis, a condition characterized by inflammation of the front portion of the eye's uvea due to internal causes. Eye surgery typically results in inflammation and pain during the healing process, which Durezol helps manage.

Mechanism of Action:
Difluprednate, the synthetic corticosteroid in Durezol, works by targeting receptors within the cells of the eye. This activation inhibits the body's inflammatory response by reducing the release of key substances, such as prostaglandins and cytokines. As a result, Durezol effectively reduces swelling, redness, pain, and other signs of eye inflammation caused by surgery or conditions like uveitis.

Use Durezol exactly as your doctor prescribes, following the instructions in the official product monograph | Novartis. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before using Durezol, it is essential to discuss all potential side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Durezol, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects – The following are examples of some common side effects of Durezol; however, other side effects may occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Blurred vision
• Eye pain
• Eye redness
• Increased sensitivity to light (photophobia)
• Increased tearing

Serious or rare side effects – Stop using Durezol and seek immediate medical attention right away if you experience any of the following:
• Allergic reactions, including angioedema, hives, and trouble breathing
• Changes in vision
• Severe eye pain
• Signs of cataracts, such as blurry or double vision, sensitivity to light, or difficulty seeing at night.
• Signs of eye infection, such as increased redness, pus, or crusting
• Signs of increased pressure in the eye, such as blurred vision, halos around lights, or severe eye pain

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist before starting Durezol.

Durezol should not be used if:
• Are allergic to difluprednate or any of the inactive ingredients in Durezol
• You have a mycobacterial infection of the eye (e.g., ocular tuberculosis)
• You have a viral disease of the cornea and conjunctiva, such as epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella.
• You have fungal diseases of the ocular structures
• You have untreated glaucoma

Tell your doctor about all of your medical conditions, past and present, before starting Durezol. This is crucial because certain conditions can affect whether Durezol is right for you. These conditions may include, but are not limited to:
• Cataracts
• Glaucoma

Contact Lenses:
Do not use Durezol if you use contact lenses. Always remove the contact lens before instilling the medicine. You can reinsert the lenses 15 minutes after each dose.

Driving and other activities:
Durezol may cause blurred vision and may impair your thinking or reactions. Be cautious if you drive or engage in any activity that requires you to be alert and have clear vision.

Long-term Use:
Prolonged use of topical corticosteroids, such as Durezol, may result in ocular hypertension or glaucoma, leading to optic nerve damage, reduction in visual acuity, and visual field defects, as well as the formation of posterior subcapsular cataracts. Therefore, regular and thorough eye examinations by an ophthalmologist are crucial, especially if you have a history of glaucoma or are using Durezol for an extended period.

Secondary Ocular Infections:
Durezol may suppress the immune response and increase the risk of secondary ocular infections. Inform your doctor if you experience any signs or symptoms of a disease.

Usage Caution:
Do not touch the dispensing tip of Durezol or touch the tip to your eye or any other surface. Doing so can contaminate the medicine, which can lead to eye infections that can cause vision loss or severe damage to the eye.

Drug Interactions:

Before using Durezol, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete information about potential drug interactions, please visit the Details for Durezol - Drug and Health Product Register at https://hpr-rps.hres.ca/details.php?drugproductid=2052.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Durezol can interact with other medicines. If you are using multiple topical ophthalmic medications, they should be administered at least 5 minutes apart.

Pregnancy and Breastfeeding:

If you are pregnant or become pregnant, tell your doctor before using Durezol. It is unknown if difluprednate will harm an unborn baby. It is crucial to discuss the risks and benefits of using Durezol with your doctor before using it. If you are breastfeeding or plan to breastfeed, inform your doctor. It is unknown if difluprednate is excreted in human breast milk or if it will harm a nursing infant. It is crucial to discuss the risks and benefits of using Durezol with your doctor before using it.

Use in Children:

The safety and effectiveness of Durezol in children below 2 years old have not been established.

Frequently Asked Questions about Durezol at Canada Pharmacy Online

Why is Durezol more affordable in Canada than in the United States?

Prescription drug prices, including Durezol, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Durezol ophthalmic emulsions I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Durezol at one time, as per your doctor's prescription.

Can I buy Durezol over the counter from you?

No, Durezol requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

How should I use Durezol?

Use Durezol exactly as prescribed by your doctor. To apply the Durezol eye drops, wash your hands first. Then, tilt your head back slightly and pull down your lower eyelid to create a pocket. Look up and away while squeezing a drop into the pocket. Be sure not to touch any part of the eye. Close your eyes for 1-2 minutes with your head tipped down. Do not blink or open your eyes. Gently press your finger to the inside corner of the eye for one minute to keep the medication from draining into your tear duct. Wait 5 minutes between drops if more than one drop is prescribed per eye.

How long does it take Durezol to work?

Inform your doctor if you do not see improvements after 2 days of treatment.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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