Xeloda (Capecitabine)

Name: Xeloda
Brand: Generic
SKU: 2525
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no brand product of Xeloda.

Generic Equivalent of Xeloda

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Capecitabine

Manufacturer: Generic

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Type:

Product: Capecitabine

Manufacturer: Generic

Country: Canada

Dosage: 500 mg

Qty-Price (USD):

Xeloda Information

CanadaPharmacyOnline.com supplies only genuine Xeloda from Canada shipped using the Canadian packaging. This Xeloda is manufactured by Genetech Inc. (a member of Roche Group), the worldwide manufacturer of Xeloda. This offer is neither endorsed nor authorized by Genetech Inc. (the United States and Canadian distributor of Xeloda). CanadaPharmacyOnline.com has no affiliation whatsoever with Genetech Inc.

Generic Capecitabine at CanadaPharmacyOnline.com

The manufacturer of brand-name Xeloda is Roche Canada and Roche Turkey. The brand product is currently unavailable (at this pharmacy). Generic capecitabine is also available. The specific manufacturer of the dispensed medication may vary depending on pharmacy inventory. Generic capecitabine is sourced from manufacturers that meet applicable regulatory standards.

Important Information about Generic Capecitabine

Generic capecitabine contains the same active ingredient as brand-name Xeloda. It must meet the same effectiveness and quality standards. This means it is designed to work like Xeloda. Studies have shown that generic capecitabine is bioequivalent to brand-name Xeloda, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit “Access to Generic Drugs in Canada | Canada.ca”.

Dosage:

Capecitabine is available in the following oral strengths at this pharmacy:
• Tablets: 150 mg and 500 mg film-coated tablets.

The exact daily dose depends on your body surface area (height and weight) and will be calculated by your oncologist. Dose reductions may be required based on tolerability. Do not stop or change your dose without consulting your oncologist.

Usage:

Xeloda (capecitabine) is an oral fluoropyrimidine carbamate chemotherapy drug indicated for the treatment of colorectal cancer (as first-line monotherapy, or in combination), breast cancer (both as first-line combination therapy with docetaxel in metastatic disease, and as monotherapy when prior anthracycline-based therapy has failed), and gastric cancer. Xeloda is a convenient oral alternative to intravenous fluorouracil (5-FU), the standard chemotherapy for colorectal and breast cancer.

Mechanism of Action
Capecitabine is an oral prodrug, meaning it is inactive when you swallow it, turning into an active chemotherapy drug only after it enters your body. The pill goes through a three-step breakdown process. The final step relies heavily on an enzyme called thymidine phosphorylase, which is naturally present at much higher levels in tumor tissue than in normal healthy tissue. Because of this setup, the drug converts into its active, cancer-killing form, 5-fluorouracil (5-FU), primarily within tumor cells. Once active, it blocks the machinery the cancer cells need to copy their DNA, effectively preventing them from dividing and causing them to break down. Traditionally, 5-FU had to be administered via long, continuous intravenous (IV) infusions through an active chest line. Capecitabine provides the same active treatment in a highly convenient oral tablet you can take safely at home.

Take Xeloda exactly as your oncologist prescribes, following the instructions in the package leaflet. Take within 30 minutes after a meal. Do not miss doses. If you miss a dose, do not take a double dose to make up for it. Always wash your hands thoroughly with soap and water after touching your tablets. Caregivers should wear disposable gloves if handling the medication for you. Swallow the tablets whole with water. Do not cut, crush, or chew them.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Xeloda, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Xeloda (capecitabine). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Xeloda; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Diarrhea
• Fatigue or weakness
• Hand-foot syndrome, including redness, swelling, peeling, or painful sores on the palms and soles
• Mouth sores (stomatitis)
• Nausea or vomiting

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Cardiac Toxicity: Chest pain, arrhythmias, or symptoms of a heart attack.
• Severe Bone Marrow Suppression: Fever, chills, or unusual bruising or bleeding. Blood counts are monitored regularly during treatment.
• Severe Diarrhea or Dehydration: Four or more loose stools per day beyond your normal frequency, or any diarrhea at night.
• Severe Hand-Foot Syndrome: Blistering, ulceration, or inability to walk or use your hands normally. Stop Xeloda and contact your oncologist immediately.
• Severe Mucositis/Stomatitis: Painful mouth sores that prevent eating or drinking. Stop Xeloda and contact your oncologist.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Xeloda, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Xeloda/capecitabine if:
• Allergies: Known hypersensitivity to capecitabine, 5-fluorouracil, or any ingredient in the tablet.
• DPD Deficiency (Dihydropyrimidine Dehydrogenase deficiency): Complete or near-complete DPD deficiency is a contraindication. Get tested for this condition before the first dose to prevent fatal toxicities.
• Severe Renal Impairment (creatinine clearance below 30 mL/min).

Tell your doctor about all of your medical conditions, past and present, before starting Xeloda. This is crucial as certain conditions affect the drug's safety.
• DPD deficiency
• Heart disease
• Kidney or liver disease

Drug Interactions:

Before taking Xeloda, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the product monograph at https://pdf.hres.ca/dpd_pm/00035936.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Xeloda. Xeloda may interact with other medicines, including but not limited to:
• Folic acid (folate) and folinic acid (leucovorin): May increase the toxicity of capecitabine by enhancing 5-FU's inhibition of thymidylate synthase.
• Other fluoropyrimidines or drugs metabolized via the DPD pathway may cause additive toxicity.
• Phenytoin: Capecitabine increases phenytoin levels.
• Warfarin (and other coumarin anticoagulants): Capecitabine significantly increases the anticoagulant effect of warfarin, substantially raising INR and the risk of serious bleeding.

Pregnancy and Breastfeeding:

Xeloda can cause harm to an unborn baby. Women of childbearing potential must use effective contraception during treatment and for at least 6 months after the final dose. Male patients should also use contraception during treatment and for 3 months after the final dose. Xeloda must not be used during pregnancy. Breastfeeding must be discontinued while taking Xeloda.

Use in Children:

The safety and efficacy of Xeloda in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Xeloda at Canada Pharmacy Online

Why is Xeloda more affordable in Canada than in the United States?

Prescription drug prices, including Xeloda, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Xeloda I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Xeloda per prescription from your doctor.

Can I buy Xeloda from you over the counter?

No, Xeloda requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Xeloda?

Yes, the generic capecitabine is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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