Zelboraf (Vemurafenib)

Name: Zelboraf
Brand: Hoffman - La Roche
SKU: 6859
Availability: InStock

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Product

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Qty-Price (USD)

Type:

Product: Zelboraf

Manufacturer: Hoffman - La Roche

Country: Canada

Dosage: 240 mg

Qty-Price (USD):

Generic Equivalent of Zelboraf

Type

Product

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There is no generic product of Zelboraf.

Zelboraf Information

Zelboraf at CanadaPharmacyOnline.com

The manufacturer of brand-name Zelboraf (vemurafenib) is Hoffman-La Roche. It is available in many countries worldwide, including Canada.

The generic vemurafenib is currently unavailable (at this pharmacy).

Dosage:

Zelboraf (vemurafenib) is available in the following oral strengths at this pharmacy:
• Tablets: 240 mg film-coated tablets.

Dosage is individualized and based on your tolerability.

Usage:

Zelboraf (vemurafenib) is a BRAF kinase inhibitor indicated for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600E mutation, as confirmed by an approved test. Your doctor will perform a skin biopsy to harvest a tissue sample, which will then undergo specialized molecular/genetic laboratory testing to confirm if you have the BRAF V600E mutation before prescribing Zelboraf.

Mechanism of Action
Vemurafenib is a selective inhibitor of the BRAF V600E mutant kinase. BRAF is a protein kinase that is part of the MAPK signaling pathway (RAF-MEK-ERK), which controls cell growth and division. In approximately 50% of melanomas, the BRAF gene has a specific mutation (V600E) that makes the protein constitutively active, continuously stimulating cancer cell proliferation without normal controls. By selectively binding to the V600E mutant BRAF and blocking its kinase activity, vemurafenib interrupts this signaling cascade, reducing cancer cell proliferation and promoting cancer cell death.

Take Zelboraf exactly as your oncologist prescribes and as directed in the patient information leaflet. Take twice daily at the same times each day. Do not crush or chew the tablets. Swallow whole with water. If a dose is missed, it can be taken up to 4 hours before your next scheduled dose. If it is within 4 hours of your next dose, skip the missed dose and take the next scheduled dose. Do not stop treatment without consulting your oncologist. BRAF V600E mutation testing must be performed before starting Zelboraf.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Zelboraf, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Zelboraf (vemurafenib). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Zelboraf; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Arthralgia (joint pain) — one of the most common side effects
• Fatigue
• Hair loss (alopecia)
• Nausea
• Photosensitivity (severe sunburn with even brief sun exposure)
• Skin rash

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Cutaneous Squamous Cell Carcinoma (cuSCC) and New Primary Melanomas: BRAF inhibition can paradoxically activate the MAPK pathway in cells with RAS mutations, promoting the growth of new skin cancers. Skin examinations are performed every 2 months during treatment and for 6 months after stopping. Report any new skin lesions promptly.
• Liver Toxicity (Hepatotoxicity): Jaundice, dark urine, or fatigue. Liver function must be monitored regularly.
• QT Interval Prolongation: Palpitations, dizziness, or fainting. ECG monitoring is required before and during treatment.
• Serious Skin Reactions: Erythema multiforme, Stevens-Johnson syndrome, or toxic epidermal necrolysis. Discontinue Zelboraf immediately if serious skin reactions occur.
• Severe Photosensitivity: Severe sunburn or blistering skin after minimal sun exposure. Use broad-spectrum SPF 30+ sunscreen, protective clothing, and limit sun exposure during treatment.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Zelboraf, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Zelboraf/vemurafenib if:
• Allergies: Known hypersensitivity to vemurafenib or any ingredient in the tablet.
• Wild-type BRAF melanoma or unknown BRAF status: Zelboraf must not be used without confirmed BRAF V600E mutation status.

Tell your doctor about all of your medical conditions, past and present, before starting Zelboraf. This is crucial as certain conditions affect the drug's safety.
• Any skin changes
• Electrolyte abnormalities
• Heart conditions
• Liver disease

Drug Interactions:

Before taking Zelboraf, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the product monograph at https://assets.roche.com/f/173850/x/076d7f9bf1/zelboraf_pm_e.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Zelboraf. Zelboraf may interact with other medicines, including but not limited to:
• CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, St. John's Wort): Reduce vemurafenib levels; avoid.
• CYP3A4 substrates: Vemurafenib is a CYP3A4 inducer and can lower the levels and effectiveness of other drugs metabolized by this enzyme (e.g., midazolam, oral contraceptives, certain immunosuppressants). Close monitoring or dose adjustments of those medications may be required.
• Drugs that prolong QT interval: Additive QT-prolongation risk; generally, avoid.
• Warfarin: Vemurafenib increases warfarin levels; monitor INR closely.

Pregnancy and Breastfeeding:

Zelboraf can cause harm to an unborn baby. Do not use this drug during pregnancy. Women of childbearing potential must use two effective methods of contraception during treatment and for at least 6 months after the final dose. Note that vemurafenib reduces the effectiveness of hormonal contraceptives because it induces the CYP3A4 enzyme, speeding up how fast your body breaks down the birth control. You must use a reliable non-hormonal backup contraceptive (such as condoms or a copper IUD). Breastfeeding is not recommended while taking Zelboraf.

Use in Children:

The safety and efficacy of Zelboraf in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Zelboraf at Canada Pharmacy Online

Why is Zelboraf more affordable in Canada than in the United States?

Prescription drug prices, including Zelboraf, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Zelboraf I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Zelboraf per prescription from your doctor.

Can I buy Zelboraf from you over the counter?

No, Zelboraf requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Zelboraf?

The generic equivalent is currently unavailable (at this pharmacy).

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CanadaPharmacyOnline.com supplies only genuine Zelboraf from Canada shipped using Canadian packaging. This Zelboraf is manufactured by Genetech Inc. (a member of Roche Group), the worldwide manufacturer of Zelboraf. This offer is neither endorsed nor authorized by Genetech Inc. (the United States and Canadian distributor of Zelboraf). CanadaPharmacyOnline.com has no affiliation whatsoever with Genetech Inc.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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