Zomig Nasal Spray (Zolmitriptan)

Name: Zomig Nasal Spray
Brand: Xediton Pharmaceuticals
SKU: 7540
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Zomig Nasal Spray 2 Units per Pack

Manufacturer: Xediton Pharmaceuticals

Country: Canada

Dosage: 2.5 mg

Qty-Price (USD):

Type:

Product: Zomig Nasal Spray 6 Units per Pack

Manufacturer: Xediton Pharmaceuticals

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Generic Equivalent of Zomig Nasal Spray

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Zolmitriptan (Zolmist - Cipla)

Manufacturer: Generic

Country: India

Dosage: 5 mg/0.7 ml/7 dose

Qty-Price (USD):

Zomig Nasal Spray Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on November 19, 2025.

Zomig Nasal Spray and Zolmitriptan at CanadaPharmacyOnline.com

Zomig is the brand name for the migraine drug zolmitriptan. AstraZeneca originally developed it and is available in different countries. In Canada, Xedition Pharmaceuticals markets and distributes Zomig Nasal Spray.

Generic zolmitriptan is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Zolmitriptan:

Generic zolmitriptan contains the same active ingredient as the brand-name Zomig and must meet the same safety, effectiveness, and quality standards as the brand-name product. This means it’s designed to work in the same way as zolmitriptan. Studies have demonstrated bioequivalence between generic and brand-name zolmitriptan, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic Zolmitriptan, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

At our pharmacy, Zomig Nasal Spray is currently available in the strength of:
• 2.5 mg per single-use spray.

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage:

Zomig (zolmitriptan) is a prescription medication used to relieve migraine headaches once it has already begun, including those accompanied by an aura, nausea, or vomiting. If the migraine symptoms improve but then return after two hours or more, a second dose may be used; however, if the first dose provided no benefit, you should not take a second dose for that same attack without first consulting your doctor.

Mechanism of Action
Zomig (zolmitriptan) is a type of anti-migraine medication that works by targeting specific serotonin receptors (5-HT) in the brain, specifically the 5-HT1B and 5-HT1D receptors.

During a migraine, certain blood vessels in the brain can become painfully enlarged, and nerves release chemicals that cause inflammation and pain signals. Zolmitriptan, a triptan, works in two ways: first, it stimulates receptors on blood vessel walls, causing the swollen vessels to constrict (narrow), which helps relieve the throbbing pain. Second, it blocks the release of pain-causing chemicals, such as CGRP, from nerve endings, effectively cutting off pain signals sent to the brain. By addressing both blood vessel changes and pain pathways, Zomig provides effective relief from migraines and their associated symptoms.

Take Zomig Nasal Spray exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Zomig Nasal Spray, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Zomig Nasal Spray, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Zomig Nasal Spray; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Atypical sensations (e.g., tingling, burning, or numbness, often called paresthesia)
• Dizziness
• Dry mouth
• Nasal discomfort (irritation, soreness, or burning in the nose)
• Nausea
• Pain, pressure, or tightness in the throat, neck, or jaw
• Somnolence (sleepiness or unusual drowsiness)
• Unusual taste in the mouth (often unpleasant)
• Weakness or lack of strength

Other Potential Side Effects (less common):
• Abdominal pain or stomach discomfort
• Chills
• Flushing (feeling hot or a warm sensation)
• Heaviness in areas other than the chest or neck
• Palpitations (feeling of a fast or irregular heartbeat)

Serious Side Effects – These are rare but potentially severe side effects of Zomig nasal spray. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reaction (symptoms like swelling of the face, lips, tongue, or throat; hives; or difficulty breathing)
• Blood pressure increase (severe or uncontrolled hypertension)
• Gastrointestinal ischemic events (sudden, severe stomach pain, bloody diarrhea, or signs of poor blood flow to the gut)
• Heart attack or coronary artery vasospasm (symptoms like severe chest pain or pressure spreading to the shoulder or jaw, cold sweat, or shortness of breath)
• Medication Overuse Headache (MOH) (headaches that worsen or occur more frequently if the medication is used more than 10 days per month)
• Serotonin Syndrome (symptoms like agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, twitching, overactive reflexes, or severe nausea/vomiting/diarrhea)
• Stroke or Transient Ischemic Attack (TIA) (sudden numbness or weakness on one side of the body, slurred speech, sudden severe headache, or trouble with vision or balance)

Contraindications

The following is not an exhaustive list of contraindications. Before starting Zomig Nasal Spray, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Zomig Nasal Spray should not be used if any of the following apply to you.

Cardiovascular and Blood Vessel Issues
• Any history of stroke or transient ischemic attack (TIA).
• Coronary artery vasospasm (Prinzmetal's angina).
• Ischemic heart disease (e.g., angina, history of heart attack).
• Peripheral vascular disease (PVD) or ischemic bowel disease. (The drug affects blood vessels everywhere.)
• Uncontrolled high blood pressure (hypertension).
• Wolff-Parkinson-White Syndrome or other dangerous irregular heart rhythms.

Drug Interaction Conflicts
• You have taken another triptan or an ergot-type medication (like ergotamine) within the last 24 hours. (Do not mix vasoconstrictors!)
• You have taken an MAO-A inhibitor in the past two weeks (14 days).

Migraine Type and Allergy
• You have basilar or hemiplegic migraine. (Triptans are often risky for these types.)
• You have an allergy to zolmitriptan or any of the product's ingredients.

Tell your doctor about all of your medical conditions, past and present, before starting Zomig. This is crucial because certain conditions affect whether Zomig is right for you. These conditions may include, but are not limited to:
• Liver disease (moderate to severe)
• Multiple cardiovascular risk factors (e.g., smoking, obesity, diabetes, high cholesterol, postmenopausal women, men over 40)
• Phenylketonuria (PKU), as the orally disintegrating tablet (Zomig-ZMT) contains phenylalanine
• Current or recent use of Serotonin-Affecting Antidepressants (SSRIs/SNRIs), due to the heightened risk of Serotonin Syndrome. (This risk requires close monitoring.)

Drug Interactions

Before discussing Zomig Nasal Spray, it is essential to review all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information highlights of prescribing information from DailyMed (.gov) at https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f2073122-5138-41ba-b791-a9b088bb98b7&type=display.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC drugs, vitamins, and herbal supplements. Zomig Nasal Spray may interact with other medicines, but is not limited to:

Do NOT Mix (Must Be Separated)
These combinations can cause severe, life-threatening cardiovascular problems (vasospasm) or dangerously high drug levels.
• Other Triptans (5-HT Agonists): (e.g., sumatriptan, rizatriptan): Do not use within 24 hours of taking Zomig. Due to an Increased risk of severe vasospasm and cardiovascular events.
• Ergot-Type Medications: (e.g., ergotamine, dihydroergotamine): Do not use within 24 hours of taking Zomig. Due to a high risk of prolonged, severe vasospasm (blood vessel narrowing).
• MAO Inhibitors (MAOIs): (e.g., phenelzine, tranylcypromine): Do not use Zomig if you have taken an MAO inhibitor within the past 14 days (2 weeks). Due to significantly increased Zomig blood levels, there is a risk of serious side effects.

High Risk of Serotonin Syndrome (Requires Close Monitoring)
Combining Zomig with these drugs can lead to Serotonin Syndrome, a serious condition affecting the nervous system.
• SSRIs (e.g., fluoxetine, sertraline)
• SNRIs (e.g., duloxetine, venlafaxine)
• Tricyclic Antidepressants (e.g., amitriptyline)
• St. John's Wort (Herbal Supplement): It requires close monitoring by a doctor, especially when starting or increasing the dose of either medication.

Dose Adjustments Required (Limit Zomig to 5 mg/day)
These medications can slow the breakdown of Zomig, increasing its concentration in your body.
• Cimetidine (Tagamet)
• Quinolone Antibiotics (e.g., ciprofloxacin, levofloxacin): If used together, the maximum daily dose of Zomig must be limited to 5 mg per day.

Pregnancy and Breastfeeding

Always consult your healthcare provider before using Zomig (zolmitriptan) Nasal Spray if you are pregnant or breastfeeding, as there is limited conclusive human safety data.
• During Pregnancy: Zolmitriptan is typically only recommended if the benefits of treating severe migraine clearly outweigh the potential risks to the fetus, especially since some animal studies have shown possible adverse effects.
• While Breastfeeding: Only small amounts of zolmitriptan are thought to pass into breast milk, suggesting a low risk to the infant. However, many healthcare providers will recommend an extra layer of caution by either:
o Suggesting alternative triptans (like sumatriptan) that have more established safety profiles.
o Advising you to avoid breastfeeding for 24 hours after taking a dose to minimize infant exposure.

Use in the Elderly

Zomig (zolmitriptan) Nasal Spray is generally not recommended for older adults aged 65 and older. Since the safety and effectiveness haven't been established, and because this age group is at a higher risk for uncontrolled high blood pressure and heart problems (absolute contraindications for all triptans), your doctor must perform a thorough cardiovascular evaluation before considering Zomig Nasal Spray.

Use in Children

Zomig Nasal Spray is generally not approved for use in individuals under 18 years of age.

Frequently Asked Questions about Zomig Nasal Spray at Canada Pharmacy Online:

Why is Zomig Nasal Spray more affordable in Canada than in the United States?

Prescription drug prices, including Zomig Nasal Spray, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is committed to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of Zomig Nasal Spray units I can order at once?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Zomig Nasal Spray at one time, as per your doctor's prescription.

Can I buy Zomig Nasal Spray from you over the counter?

No, Zomig Nasal Spray requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Zomig Nasal Spray?

Yes, there is a generic alternative for this product called Zolmitriptan.

What should I avoid while using Zomig?

Zomig Nasal Spray may cause drowsiness. Do not drive or operate heavy machinery until you are sure that you are not drowsy.

Is Zomig a controlled substance?

Zomig belongs to the class of antimigraine drugs and is used for the treatment of migraine. Zomig Nasal spray is not a co.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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