Monurol (Fosfomycin Tromethamine)

Name: Monurol
Brand: Paladin
SKU: 6900
Availability: InStock

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Type:

Product: Monurol Powder Sachet

Manufacturer: Paladin

Country: Canada

Dosage: 3 gm

Qty-Price (USD):

Generic Equivalent of Monurol

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There is no generic product of Monurol.

Monurol Information

Monurol at CanadaPharmacyOnline.com

The manufacturer of Monurol (fosfomycin tromethamine) in Canada is Paladin Labs Inc., a leading Canadian specialty pharmaceutical company. Monurol is a unique, single-dose antibiotic developed initially to provide a convenient and effective treatment for specific urinary tract infections. While Paladin serves the Canadian market, the drug is recognized globally for its distinct chemical structure, which is unrelated to other common antibiotic classes like penicillins or cephalosporins.

The generic Fosfomycin tromethamine is currently unavailable (at this pharmacy).

Dosage:

Monurol (fosfomycin) is available in a specialized, single-use dosage form:
• 3 g Oral Powder Sachet: Each packet contains granules of fosfomycin tromethamine, typically flavored with mandarin or orange.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions. For most adult women with an uncomplicated bladder infection, the standard treatment is a single 3 g dose dissolved in water.

Usage:

Monurol is an antibiotic primarily used to treat uncomplicated urinary tract infections (UTIs), such as acute cystitis, in women. It is specifically designed to target bacteria such as E. coli, which commonly cause bladder irritation and pain. Because the medication is highly concentrated in the urine, it continues to fight the infection for several days after the single dose is swallowed. Unlike many other antibiotics that require a week-long course, Monurol offers a shorter treatment window. However, it is essential to note that it is not intended for more serious infections that have spread to the kidneys (pyelonephritis). Symptoms of kidney infections include high fever, chills, or pain in your side or lower back. As it only works against bacteria, it will not treat viral infections like the common cold or flu. Most patients begin to feel significant relief from symptoms like burning or urgency within 2 to 3 days after taking the dose.

Mechanism of Action
Fosfomycin, the active agent in Monurol, works by attacking the very foundation of a bacterial cell's survival. It is a bactericidal antibiotic that kills bacteria by preventing them from building their cell walls. Specifically, it inhibits an enzyme called UDP-N-acetylglucosamine enolpyruvyl transferase (also known as MurA), which is essential for the very first stage of cell wall synthesis. By blocking this early step, the medication prevents the bacteria from producing the protective outer layer they need to stay intact. Without a functional cell wall, the bacteria eventually burst and die. Additionally, Monurol has a secondary benefit: it can reduce bacteria's ability to adhere to the bladder lining. By making the bladder walls "slippery" to bacteria, the medication helps the body flush the infection out more effectively.

Take Monurol exactly as your doctor prescribes, following the instructions in the product monograph. Consult your doctor for personalized guidance and safe use. Do not swallow the powder. Dissolve it in about half a cup (125 mL) of cold water and consume it immediately. It is most effective when taken on an empty stomach at bedtime, immediately after emptying the bladder. This allows the medication to reach and maintain its highest concentration in the bladder for several hours while you sleep.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Monurol, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Monurol (fosfomycin tromethamine). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Monurol; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea (the most frequently reported side effect)
• Dizziness
• Headache
• Nausea or upset stomach
• Vaginal itching or irritation (vaginitis)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: A severe allergic reaction involving hives, swelling of the face or throat, and difficulty breathing.
• C. diff-associated Diarrhea: Severe, watery, or bloody diarrhea that may be accompanied by fever and stomach cramps.
• Vision Changes: Any sudden blurriness or changes in sight.
• Unusual Weakness: Intense fatigue or lack of energy that does not go away.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Monurol, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Monurol/fosfomycin tromethamine if:
• Allergies: You have a known hypersensitivity to fosfomycin or any inactive ingredients (such as sucrose or flavorings).
• Severe Kidney Impairment: If your kidneys are not functioning well enough to clear the medication.

Tell your doctor about all of your medical conditions, past and present, before starting Monurol. This is crucial as certain conditions affect the drug's safety.
• Diabetes: Monurol sachets contain sugar (sucrose), which those managing blood glucose should consider.
• History of Liver Issues: While rare, liver enzyme changes can occur.
• Kidney Problems: Patients on hemodialysis should generally avoid this medication.

Drug Interactions:

Before taking Monurol, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please check the product monograph at: https://pdf.hres.ca/dpd_pm/00044185.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Monurol. Monurol may interact with other medicines, including but not limited to:
• Live Vaccines: Like most antibiotics, Monurol may decrease the immune response to live bacterial vaccines, such as the oral typhoid vaccine (Ty21a). It is generally recommended to wait 24 hours after your last antibiotic dose before receiving such a vaccine.
• Metoclopramide: This medication, often used for stomach issues, increases gastrointestinal motility. This can lower the serum concentration and the total amount of Monurol excreted into the urine, potentially reducing its effectiveness.
• Vitamins and Supplements: Inform your doctor of all supplements you take, as certain minerals may affect absorption.

Pregnancy and Breastfeeding:

Monurol should only be used during pregnancy if clearly needed and prescribed by a doctor. While it has a long history of use for "asymptomatic bacteriuria" in pregnant women with no known harmful effects on the fetus, a doctor must weigh the benefits against the risks. Small amounts of fosfomycin pass into breast milk, but it is generally considered unlikely to harm a nursing infant. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Use in Children:

The safety and effectiveness of Monurol in children under 12 years of age have not been established. It is approved for use in adolescents aged 12 to 18 and adults for the treatment of uncomplicated cystitis.

Frequently Asked Questions about Monurol at Canada Pharmacy Online

Why is Monurol more affordable in Canada than in the United States?

Prescription drug prices, including Monurol, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Monurol I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Monurol per prescription from your doctor.

Can I buy Monurol over the counter from you?

No, Monurol requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Monurol?

No, the generic fosfomycin tromethamine is currently unavailable (at this pharmacy).

Blog Post:

EMBARRASSED by OAB? 3 Surprising Things That Calm the Bladder

Latest News:

FDA approves new IV antibiotic for complicated urinary tract infections (article published on November 5, 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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