Estrogel Gel (Estradiol)

Name: Estrogel Gel
Brand: Organon
SKU: 6085
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Estrogel Gel

Manufacturer: Organon

Country: Canada

Dosage: 0.06 %/80 gm

Qty-Price (USD):

Type:

Product: Estrogel Gel

Manufacturer: Besins

Country: United Kingdom

Dosage: 0.06 %/80 gm

Qty-Price (USD):

Generic Equivalent of Estrogel Gel

Type

Product

Manufacturer

Country

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Qty-Price (USD)

There is no generic product of Estrogel Gel.

Estrogel Gel Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on July 22, 2025.

Estrogel at CanadaPharmacyOnline.com

The brand Estrogel (estradiol) is manufactured and marketed by Organon in Canada. It is also known as Oestrogel, manufactured by Besins in the United Kingdom.

The generic version of estradiol gel is not currently available at this pharmacy.

Dosage

Estrogel is a transdermal gel containing 0.06% estradiol. It is supplied in an 80-gram metered-dose pump dispenser.

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage

Estrogel (estradiol) is a form of estrogen hormone therapy. It is used to treat specific symptoms of menopause by replacing the estrogen that the body no longer produces in sufficient amounts. Common uses include:
• Moderate to Severe Symptoms of Vulvar and Vaginal Atrophy: Treatment of symptoms such as vaginal dryness, irritation, itching, and painful intercourse associated with menopause. When prescribing solely for these symptoms, healthcare providers may first consider topical vaginal products.
• Moderate to Severe Vasomotor Symptoms (Hot Flashes) due to Menopause: Treatment of hot flashes and night sweats.

Mechanism of Action
Estrogel (estradiol) is an estrogen. It works by supplementing the body's natural estrogen levels, which decline during menopause. Estradiol, as an estrogen, binds to estrogen receptors in target tissues, including the reproductive organs, breasts, bones, and certain areas of the brain. This binding initiates cellular responses that help alleviate menopausal symptoms. When applied topically as a gel, estradiol is absorbed directly into the bloodstream through the skin, bypassing initial metabolism by the liver (first-pass metabolism) that occurs with oral estrogen. This transdermal delivery helps maintain consistent estrogen levels in the body.

Take Estrogel exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Estrogel, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Estrogel, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Estrogel; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Acne
• Application site reactions (e.g., dryness, pain, discoloration, rash, itching, redness)
• Breast pain or tenderness
• Changes in appetite or weight
• Changes in menstrual periods or unexpected vaginal bleeding/spotting (especially in the first few months)
• Dizziness
• Fluid retention (swelling of fingers, hands, ankles)
• Hair loss or thinning
• Headache (can be severe or migraine-like)
• Irritability or mood changes (including low mood or depression)
• Nausea
• Nervousness
• Stomach cramps and bloating
• Vaginal pain, dryness, or discomfort
• Vomiting

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Severe rash, hives, swelling of the face, lips, tongue, or throat (angioedema), difficulty breathing, fever, swollen glands.
• Breast lumps or changes: Any new lumps, dimpling of the skin, or changes in the nipple.
• Cardiovascular events:
o Blood clots: Sudden pain, warmth, redness, or swelling in an arm or leg; sudden shortness of breath; sharp chest pain that worsens with breathing; coughing up blood.
o Heart attack: Chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating, lightheadedness.
o Stroke: Sudden severe headache, sudden numbness or weakness (especially on one side of the body), slurred speech, problems with vision or balance.
• Cholestatic jaundice (yellowing of the skin or eyes)
• Exacerbation of existing endometriosis
• Fibroids (growth or recurrence of uterine fibroids)
• Gallbladder problems: Abdominal tenderness, persistent upper abdominal pain, nausea, vomiting.
• Increased blood pressure (hypertension)
• Liver problems: Symptoms like yellowing of the skin or eyes (jaundice), dark urine, persistent nausea or vomiting, pale stools, loss of appetite.
• Memory problems/Dementia: Especially in women 65 years of age or older (long-term use of estrogen-alone may increase risk).
• Pancreatitis: Severe stomach pain, nausea, vomiting.
• Undiagnosed abnormal vaginal bleeding: Any persistent or recurring abnormal bleeding, especially after menopause.
• Vision changes: Sudden complete or partial loss of vision, double vision, eye pain, redness, bulging eyes.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Estrogel, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Estrogel should not be used if:
• You are allergic to estradiol or any other ingredient in Estrogel.
• You are pregnant or may be pregnant, or are breastfeeding.
• You have active thrombophlebitis (inflammation of a vein leading to a clot).
• You have a history of, or currently have, blood clots in the legs (deep vein thrombosis), lungs (pulmonary embolism), or other thromboembolic disorders (e.g., stroke, heart attack).
• You have a history of, or currently have, breast cancer (except in exceptional circumstances where prescribed by a specialist).
• You have a history of, or currently have, endometrial cancer or other estrogen-dependent malignant neoplasia.
• You have a known or suspected estrogen-dependent tumour.
• You have a known deficiency in protein C, protein S, or antithrombin, or other known thrombophilic disorders.
• You have liver dysfunction or disease, especially of the obstructive type, where liver function tests have failed to return to normal.
• You have a partial or complete loss of vision due to ophthalmic vascular disease.
• You have undiagnosed abnormal genital bleeding.

Tell your doctor about all of your medical conditions, past and present, before starting Estrogel. This is crucial because certain conditions affect whether Estrogel is right for you. These conditions may include, but are not limited to:
• Abnormal mammogram or fibrocystic breast disease
• Asthma
• Blood pressure issues (hypertension)
• Bone disease affecting calcium or phosphorus metabolism
• Breast nodules, benign breast disease, or a strong family history of breast cancer
• Cerebrovascular disease (e.g., stroke) or coronary artery disease (e.g., angina)
• Depression
• Diabetes
• Endometriosis or uterine fibroids
• Epilepsy or other seizure disorders
• Gallbladder disease (history or active)
• History of angioedema, hereditary angioedema
• High triglyceride levels
• Hypothyroidism (underactive thyroid)
• Kidney impairment
• Liver impairment
• Lupus erythematosus
• Migraines (especially with visual aura)
• Pancreatic disease
• Porphyria (a rare hereditary blood disorder)
• Severe obesity (BMI > 30 kg/m²)
• Systemic lupus erythematosus
• Those needing prolonged bed rest (increases risk of blood clots)

Drug Interactions

Before taking Estrogel, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official Estrogel website at https://www.estrogel.com/.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Estrogel. Estrogel may interact with other medicines, but is not limited to:
• Acetaminophen (Tylenol): May increase estradiol levels.
• Aminoglutethimide: May decrease estrogen levels.
• Anticoagulants (blood thinners, e.g., warfarin): Estrogens may alter the effects of anticoagulants, potentially requiring dosage adjustments and close monitoring of INR.
• Anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine): These drugs can accelerate the metabolism of estrogens, potentially reducing their effectiveness.
• Bosentan: May decrease estrogen levels.
• Corticosteroids (e.g., prednisone): Estrogens can enhance the effects of corticosteroids.
• CYP3A4 inducers (e.g., rifampin, St. John's Wort, certain anticonvulsants like carbamazepine, phenobarbital, phenytoin): These drugs can increase the metabolism of estradiol, potentially reducing its therapeutic effect.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin, clarithromycin): These drugs can decrease the metabolism of estradiol, potentially increasing its blood levels and the risk of side effects.
• Lamotrigine: Estrogens can decrease lamotrigine levels, potentially leading to loss of seizure control. • Ritonavir- or Nelfinavir-containing regimens: Although primarily known as inhibitors, their complex enzyme interactions can sometimes induce or alter estrogen metabolism.
• Tamoxifen or Raloxifene: These medications are anti-estrogens that may interfere with the effects of Estrogel.
• Thyroid hormone replacement therapy (e.g., levothyroxine): Estrogens can increase the need for thyroid hormone. Patients on thyroid replacement therapy should have their thyroid function monitored.

Food or Lifestyle Interactions
Grapefruit juice may increase the side effects of estrogen in some individuals by inhibiting its metabolism. Avoid significant changes in grapefruit intake while using Estrogel.

Smoking can cause an increase in the risk of blood clots, especially in women over 35. Talk to your doctor or pharmacist about quitting smoking and smoking cessation products.

Pregnancy and Breastfeeding

Estrogel is contraindicated during pregnancy. Estrogens should not be used during pregnancy as there is no indication for their use in pregnant women, and potential risks to the fetus may exist.

Estradiol is excreted into breast milk. Estrogen-containing products can decrease milk supply, especially if started before lactation is well established. Therefore, Estrogel is contraindicated during breastfeeding. Consult your doctor for personalized advice.

Use in Children

Estrogel is not indicated for use in children. The safety and effectiveness in pediatric patients have not been established.

Use in Elderly

There have been no clinical studies specifically evaluating the effect of Estrogel on women aged 65 years or older. However, based on the general risks of hormone therapy, elderly patients taking Estrogel should be monitored closely, especially for cardiovascular events (stroke, blood clots), and dementia. The lowest effective dose for the shortest duration consistent with treatment goals should be used.

Frequently Asked Questions about Estrogel at Canada Pharmacy Online:

Why is Estrogel more affordable in Canada than in the United States?

Prescription drug prices, including Estrogel, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of metered doses I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Estrogel at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Estrogel requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the best time to apply Estrogel?

Estrogel should be used once daily, preferably at the same time each day. The gel should be applied to a clean, dry area of skin (typically one arm, from wrist to shoulder). Do not apply to breasts or irritated skin. Allow the gel to dry for 2-5 minutes before dressing. Do not wash the area for at least one hour after application. Your doctor will provide specific instructions.

Blog Posts:

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Latest News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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