Motilium (Domperidone)

Name: Motilium
Brand: Janssen
SKU: 2416
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Motilium Tablet

Manufacturer: Janssen

Country: New Zealand

Dosage: 10 mg

Qty-Price (USD):

Generic Equivalent of Motilium

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Domperidone Tablet

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Domperidone Tablet

Manufacturer: Generic

Country: India

Dosage: 10 mg

Qty-Price (USD):

Motilium Information

medically reviewed by Carol Hou (BSc. Pharm) on September 3, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Motilium and Domperidone at CanadaPharmacyOnline.com

The brand-name Motilium (domperidone) is manufactured by Janssen and is available in many countries worldwide, including New Zealand.

Generic domperidone is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Domperidone:

Generic domperidone contains the same active ingredient as brand-name Motilium and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Motilium. Studies have shown that generic domperidone is bioequivalent to brand-name Motilium, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts.

Dosage:

The brand Motilium and its generic equivalent, domperidone, are commonly available in 10 mg oral tablets.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Motilium (domperidone) is primarily used to treat nausea and vomiting, gastroparesis, and gastrointestinal symptoms in palliative care, as well as nausea and vomiting induced by certain dopamine agonist medications used in Parkinson's disease. It is also commonly used off-label in Canada to increase breast milk production.

Mechanism of Action:
Motilium (domperidone) works primarily by blocking dopamine D2 and D3 receptors. In the gastrointestinal tract, this blockade counteracts dopamine's natural inhibitory effect on muscle contractions, thereby increasing stomach emptying and intestinal motility (a prokinetic effect) and reducing symptoms such as bloating and indigestion. Concurrently, domperidone blocks these same dopamine receptors in the chemoreceptor trigger zone (CTZ), an area outside the brain's main blood barrier, which effectively reduces nausea and prevents vomiting (an antiemetic effect) with minimal central nervous system side effects.

Take Motilium exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Motilium, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Motilium (domperidone). It is not an exhaustive list, and individual reactions can vary.

Common Side Effects - The following are some common side effects of Motilium; however, other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal cramps, diarrhea
• Breast pain or tenderness
• Decreased sexual desire (less common)
• Dizziness
• Drowsiness
• Dry mouth
• Fatigue/weakness
• Headache
• Hot flashes
• Menstrual irregularities in women
• Nausea
• Nervousness or irritability
• Rash or itchy skin
• Swelling of the breasts in men
• Unusual breast milk production or discharge

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Signs can include rash, itching, swelling (especially of the face, lips, tongue, or throat), or difficulty breathing.
• Abrupt discontinuation or tapering of Motilium, especially when used for lactation stimulation at higher doses, can lead to symptoms like anxiety, depression, and insomnia. To minimize these effects, patients should consult their doctor for guidance on a gradual dose reduction.
• Difficulty urinating or painful urination
• Liver function changes (as seen in blood tests)
• Heart rhythm disorders: This is the most serious concern, including a fast, irregular, or pounding heartbeat, QT prolongation (a specific heart rhythm abnormality), cardiac arrest, and sudden cardiac death. The risk is higher in patients over 60 years old, those taking more than the recommended dose, or those with pre-existing heart conditions. If you experience any fast or irregular heartbeats, severe dizziness, or fainting, seek immediate medical attention. Swelling of the hands, ankles, or feet, or difficulty urinating, should also be reported to your doctor promptly, as they may indicate other severe conditions.
• Seizures or fits
• Uncontrolled movements: This can include unusual eye movements, abnormal tongue movements, muscle stiffness, tremors, or abnormal posture (such as a twisted neck). These are more likely to occur in children.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Motilium, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Motilium should not be used if you:
• Are allergic to domperidone or any of its ingredients.
• Have a prolactin-releasing pituitary tumor (prolactinoma).
• Have conditions where increased stomach/bowel contractions could be harmful (e.g., bleeding, blockage, or a tear in the intestines/stomach).
• Have specific heart problems (e.g., prolonged QT interval, heart failure, slow heartbeat).
• Have moderate or severe liver impairment.

Tell your doctor about all of your medical conditions, past and present, before starting Motilium. This is crucial because certain conditions can affect whether Motilium is right for you. These conditions may include, but are not limited to:
• Breast cancer.
• Liver Disease.
• Pituitary Gland Tumor (Prolactinoma).

Drug Interactions:

Before taking Motilium, it is essential to discuss all potential risks and interactions with your doctor or pharmacist to ensure a safe and effective use. For complete and up-to-date information, please visit the Details for Motilium from the Drug and Health Product Portal at https://dhpp.hpfb-dgpsa.ca/dhpp/resource/10691.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Motilium. Motilium may interact with other medicines, but is not limited to:
• Anticholinergic Drugs: These medications can reduce the prokinetic effect of domperidone, making it less effective. Examples include atropine, benztropine, oxybutynin, scopolamine, tolterodine, and many antihistamines (e.g., diphenhydramine, hydroxyzine).
• Potent CYP3A4 Inhibitors: These medications slow down the metabolism of domperidone in the body, leading to higher levels of domperidone and an increased risk of side effects. Many of the QT-prolonging drugs listed above also fall into this category (e.g., azole antifungals, macrolide antibiotics, HIV protease inhibitors).
• Other Medications: Dopamine Agonists (e.g., levodopa, pergolide): Domperidone can help prevent side effects such as nausea and vomiting associated with these medications, but dose adjustments may be necessary.
• Pramlintide (a synthetic amylin analog used for diabetes) slows gastric emptying.
• QT Prolonging Drugs: Domperidone itself can prolong the QT interval on an ECG, which can lead to a dangerous irregular heartbeat (arrhythmia) called Torsades de Pointes. Taking it with other medications that also prolong the QT interval significantly increases this risk.

Alcohol
It's generally advised to avoid alcohol when taking domperidone. Combining them can intensify side effects like drowsiness and dizziness, and importantly, it may elevate the risk of serious heart rhythm problems, especially for individuals over 60 or those with existing heart conditions. Alcohol can also potentially increase the chance of gastrointestinal bleeding and further impair concentration. For your safety, always consult your doctor or pharmacist for personalized advice regarding domperidone and alcohol.

Grapefruit Products
Avoid grapefruit and grapefruit juice entirely while taking domperidone. Doing so can dangerously increase the medication's levels in your body, leading to serious heart problems like abnormal heart rhythms. Other similar citrus fruits (like Seville oranges) should also be avoided. Always consult your doctor or pharmacist about food interactions with your medications.

Pregnancy and Breastfeeding

During pregnancy, use it only if the benefits outweigh the risks, as data on its use are limited. While breastfeeding, only small amounts of the substance pass into the milk, generally without causing harm to the infant. Always consult a doctor to weigh individual risks and benefits.

Use in Children

It is generally not recommended for routine use in children under 12 years or those weighing less than 35 kg due to concerns about efficacy and safety, particularly cardiac risk. A specialist should determine its use in this population.

Use in the Elderly (over 60 years old)

The risk of serious heart-related side effects is higher in individuals over 60 years old and with higher doses of domperidone (especially doses exceeding 30 mg per day, which is the maximum recommended for authorized uses).

Frequently Asked Questions about Motilium at Canada Pharmacy Online:

Why is Motilium more affordable in Canada than in the United States?

Prescription drug prices, including Motilium, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784 for more information or to learn about the ordering process. Visit our How to Order page for details.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Motilium at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Motilium requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Motilium?

Yes, there is a generic alternative for this product called domperidone.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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