Alphagan Z (Brimonidine Tartrate)

Name: Alphagan Z
Brand: Allergan
SKU: 6907
Availability: InStock

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Qty-Price (USD)

Type:

Product: Alphagan Z

Manufacturer: Allergan

Country: India

Dosage: 0.1 %/5 ml

Qty-Price (USD):

Generic Equivalent of Alphagan Z

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There is no generic product of Alphagan Z.

Alphagan Z Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on November 19, 2025.

Alphagan Z and Brimonidine Tartrate at CanadaPharmacyOnline.com

Alphagan Z, manufactured by Allergan (an AbbVie company), is a formulation of brimonidine tartrate ophthalmic solution (0.1%) and is available in many countries worldwide, including India.

Generic brimonidine is currently unavailable (at this pharmacy).

Dosage:

Alphagan Z is available as eyedrops (ophthalmic solution) containing 0.1% brimonidine, packaged in a 5 mL bottle.

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage:

Alphagan Z (Brimonidine) is a prescription medication mainly used to manage long-term open-angle glaucoma and ocular hypertension (high eye pressure).

Mechanism of Action
Alphagan Z (Brimonidine Tartrate ophthalmic solution, usually 0.1% or 0.15% concentration) is a highly selective {alpha-2} adrenergic agonist made for long-term management of high eye pressure (IOP). The "Z" in the name indicates that this formulation uses the preservative Purite (stabilized oxychloro complex), which is generally better tolerated than the traditional preservative, Benzalkonium Chloride (BAK) in older Alphagan products. The drug works through two different, complementary actions to lower pressure. The initial effect upon dosing is a reduction in aqueous humor secretion (the eye's internal fluid). However, with long-term use, its main and most sustained action is to significantly improve uveoscleral outflow, a major pathway that drains fluid from the eye. By both reducing fluid production and enhancing drainage, Alphagan Z safely and effectively lowers IOP, helping to prevent further damage to the optic nerve.

Take Alphagan Z exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Alphagan Z, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Alphagan Z, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects – The following are some common side effects of Alphagan Z; other side effects may also occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Allergic conjunctivitis (eye allergy symptoms)
• Blurred vision
• Dry mouth
• Eye itching (ocular pruritus)
• Eye redness (conjunctival hyperemia)
• Eye stinging or burning sensation
• Foreign body sensation (feeling like something is in the eye)

Other Potential Side Effects (less common):
• Abnormal taste (taste perversion)
• Abdominal pain
• Asthenia (general weakness or lack of energy)
• Blepharitis (eyelid inflammation)
• Corneal staining/erosion (damage to the clear front surface of the eye)
• Dizziness
• Dry eyes
• Eye discharge
• Eye pain
• Eyelid swelling
• Headache
• Hypertension (increased blood pressure)
• Light sensitivity (Photophobia)
• Somnolence (Drowsiness or tiredness)
• Tearing (Epiphora)

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reaction (generalized, involving hives, swelling of the face, lips, tongue, or throat, or difficulty breathing)
• Bradycardia (abnormally slow heart rate)
• Depression (worsening or new onset)
• Fainting (Syncope)
• Hypotension (very low blood pressure)
• Inflammation within the eye (Iritis)
• Keratitis (severe inflammation/infection of the cornea)

Contraindications

The following is not an exhaustive list of contraindications. Before starting Alphagan Z, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Alphagan Z should not be used if:
• You are taking a Monoamine Oxidase (MAO) inhibitor (or other antidepressant medications that affect noradrenergic transmission).
• You are using the medication in children under the age of 2 years (due to the risk of severe systemic side effects).
• You have an allergy to brimonidine tartrate or any other ingredient in the medication.

Tell your doctor about all of your medical conditions, past and present, before starting Alphagan Z. This is crucial because certain conditions affect whether Alphagan Z is right for you. These conditions may include, but are not limited to:
• Cerebral or coronary insufficiency (reduced blood flow to the brain or heart).
• Depression.
• Heart disease (severe, uncontrolled cardiovascular disease).
• Orthostatic hypotension (low blood pressure upon standing)
• Raynaud's phenomenon (a condition causing reduced blood flow to the fingers and toes).
• Renal (kidney) impairment.
• Thromboangiitis obliterans (a disease of blood vessels in the limbs).

Drug Interactions

Before taking Alphagan Z, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, visit the Patient Medication Information from AbbVie Canada at https://www.abbvie.ca/content/dam/abbvie-dotcom/ca/en/documents/products/ALPHAGAN_P_PI_EN.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Alphagan Z may interact with other medicines, but is not limited to:
• Antihypertensives (medications for high blood pressure): Concurrent use may increase the risk of hypotension (low blood pressure) due to additive blood pressure-lowering effects.
• Beta-blockers (used orally or topically in the eye): Can increase the risk of systemic effects such as bradycardia (slow heart rate) or hypotension.
• Cardiac Glycosides (e.g., Digoxin): Can increase the risk of systemic effects such as bradycardia or hypotension.
• Central Nervous System (CNS) Depressants (e.g., alcohol, barbiturates, opioids, sedatives): Alphagan Z can cause drowsiness (somnolence), and using it with these drugs can enhance the sedative effect
• MAO Inhibitors: The use of MAO inhibitors is absolutely contraindicated. MAO inhibitors block the enzymes that break down norepinephrine, a chemical that constricts blood vessels. Brimonidine can potentiate this effect, leading to excessive vasoconstriction. This combination carries a risk of a severe, potentially life-threatening spike in blood pressure (hypertensive crisis).
• TCAs (e.g., Imipramine, Amitriptyline) may interfere with the eye pressure-lowering effect by antagonizing the vasoconstrictive action (or uptake) of brimonidine at the α2 receptors, thereby reducing its efficacy in lowering IOP. Your doctor will need to closely monitor your IOP.

Pregnancy and Breastfeeding

Consult your doctor if you are pregnant or breastfeeding. Alphagan Z should only be used during pregnancy if the potential benefit outweighs the potential risk to the fetus. For breastfeeding, use is generally not recommended because the drug appears in animal breast milk and may cause serious side effects like lethargy and breathing problems in the infant.

Use in the Elderly

The safety and effectiveness of Alphagan Z (brimonidine) in people aged 65 and older have been assessed, with no overall safety concerns noted compared to younger adults. However, due to the higher prevalence of underlying health conditions in this group, such as severe heart disease, depression, or kidney problems, caution is still necessary. Regular monitoring by a healthcare provider is advised to observe for potential systemic side effects, such as excessive blood pressure reduction or increased drowsiness.

Use in Children

Alphagan Z (brimonidine tartrate) should not be used in children under 2 years old due to the high risk of serious, potentially life-threatening side effects, such as severe drowsiness, low blood pressure, slowed heart rate, and breathing problems. For children 2 years and older, this medication should only be used under strict medical supervision and close monitoring. Parents should understand that systemic side effects, such as extreme sleepiness and decreased alertness, are common, especially in children under 7 years old or weighing less than 20 kg. Always discuss the risks and benefits with your child's eye doctor before starting this medication.

Frequently Asked Questions about Alphagan Z at Canada Pharmacy Online:

Why is Alphagan Z more affordable in Canada than in the United States?

Prescription drug prices, including Alphagan Z, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Alphagan Z drops I can order at once?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Alphagan Z at one time, as per your doctor's prescription.

Can I buy Alphagan Z from you over the counter?

No, Alphagan Z requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Alphagan Z?

No, there is no generic alternative for this product.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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