Dexilant (Dexlansoprazole)

Name: Dexilant
Brand: Takeda
SKU: 6629
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Dexilant

Manufacturer: Takeda

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Dexilant

Manufacturer: Takeda

Country: Canada

Dosage: 60 mg

Qty-Price (USD):

Generic Equivalent of Dexilant

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Dexlansoprazole

Manufacturer: Generic

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Dexlansoprazole

Manufacturer: Generic

Country: India

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Dexlansoprazole

Manufacturer: Generic

Country: Canada

Dosage: 60 mg

Qty-Price (USD):

Type:

Product: Dexlansoprazole (Deltone - Alembic Pharma)

Manufacturer: Generic

Country: India

Dosage: 60 mg

Qty-Price (USD):

Dexilant Information

medically reviewed by Carol Hou (BSc. Pharm) on June 25, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Dexilant and Dexlansoprazole at CanadaPharmacyOnline.com

Brand Dexilant is manufactured by Takeda and distributed in several countries globally, including Canada.

Generic dexlansoprazole is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Dexlansoprazole:

Generic dexlansoprazole contains the same active ingredient as brand-name Dexilant and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Dexilant. Studies have shown that generic dexlansoprazole is bioequivalent to brand-name Dexilant, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

Brand Dexilant and generic dexlansoprazole are commonly available in 30 mg and 60 mg delayed-release capsules.

Your doctor will determine the appropriate dose based on your needs and medical conditions.

Usage:

Dexilant (dexlansoprazole) is a proton pump inhibitor (PPI) indicated for the treatment of specific conditions related to gastric acid, including the healing and maintenance of healed erosive esophagitis and the treatment of symptomatic gastroesophageal reflux disease (GERD). Dexlansoprazole reduces gastric acid production as a PPI by inhibiting the parietal cell H+/K+-ATPase proton pump.

Mechanism of Action:
Dexlansoprazole, a proton pump inhibitor, precisely inhibits gastric acid secretion by targeting the H+/K+-ATPase enzyme in parietal cells. As a delayed-release formulation, dexlansoprazole is absorbed in the small intestine and reaches the parietal cells via the bloodstream. Within the acidic environment of the parietal cell canaliculi, where it is activated by protonation, this activated form then binds strongly, primarily through disulfide bridges, with cysteine residues to the H+/K+-ATPase enzyme, effectively blocking the secretion of hydrochloric acid into the stomach. Dexilant provides long-lasting acid suppression by forming a stable, covalent bond that irreversibly deactivates proton pumps. Acid secretion gradually resumes as the body synthesizes new proton pumps. The dual delayed-release formulation of dexlansoprazole contributes to a sustained 24-hour reduction in gastric acidity through two distinct release phases.

Take Dexilant exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Dexilant, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Dexilant (dexlansoprazole). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Dexilant, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal pain
• Diarrhea
• Gas
• Headache
• Nausea
• Upper respiratory tract infection
• Vomiting

Less common side effects:
• Constipation
• Depression
• Dizziness
• Dry mouth
• Elevated liver enzymes
• Insomnia
• Vertigo

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Bone fractures: Increased risk, especially with long-term use (1 year or longer) or in older adults.
• Kidney problems: Decreased urination, blood in urine, fever, joint pain, swelling.
• Low magnesium levels (hypomagnesemia): Muscle spasms, tremors, seizures, irregular heartbeat, dizziness, weakness. Often associated with long-term use.
• Drug-induced lupus: New or worsening skin rash (often on sun-exposed areas), joint pain.
• Severe allergic reactions: Rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, throat, or tongue.
• Severe diarrhea: Watery or bloody stools, stomach cramps, fever. May indicate a C. difficile infection.
• Severe skin reactions: Blistering, peeling, or bleeding skin; sores on the lips, nose, mouth, or genitals; red, painful, watery eyes.
• Severe stomach conditions: Stomach cramps, bloated feeling, severe diarrhea (possibly bloody), fever, nausea, vomiting, unusual tiredness or weakness.
• Stomach polyps (fundic gland polyps): May not cause symptoms but can be detected during endoscopy, usually with long-term use.
• Vitamin B-12 deficiency: Weakness, tiredness, difficulty breathing, tingling or numbness in hands or feet, problems thinking. Usually with long-term use (3 years or longer).

Long-Term Use Side Effects:
• Bone fractures
• Drug-induced lupus
• Fundic gland polyps
• Hypomagnesemia
• Increased risk of C. difficile-associated diarrhea
• Kidney problems
• Possible increased risk of pneumonia (further research needed)
• Vitamin B-12 deficiency

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Dexilant, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Dexilant should not be used if:
• You are allergic to dexlansoprazole or any of the other ingredients in the medication;
• You are taking rilpivirine (used to treat HIV). Dexilant can decrease the effectiveness of rilpivirine

Tell your doctor about your medical conditions, past and present, before starting Dexilant. This is crucial because certain conditions affect whether Dexilant is right for you. These conditions may include, but are not limited to:
• Allergies: It's crucial to inform your doctor of any allergies, especially to other PPI medications or any inactive ingredients in Dexilant.
• Kidney problems: While the liver primarily metabolizes dexlansoprazole into inactive metabolites, the kidneys mainly eliminate these metabolites. Inform your doctor if you have kidney problems, as impaired kidney function may affect the elimination of these metabolites from your body, potentially requiring dosage adjustments.
• Liver problems: While no dosage adjustment is typically required for mild hepatic impairment (Child-Pugh Class A), a maximum daily dose of 30 mg is usually recommended for moderate hepatic impairment (Child-Pugh Class B). Dexlansoprazole is generally not recommended for patients with severe hepatic impairment (Child-Pugh Class C).
• Low magnesium levels in the blood: Long-term use of Dexilant may decrease magnesium levels by reducing its absorption in the intestines. This risk is higher with prolonged treatment and can lead to serious side effects. Your doctor may monitor your magnesium levels, especially if you are on Dexilant for an extended period or take other medications that can also lower magnesium.
• Osteoporosis or low bone density: Long-term and high-dose use of proton pump inhibitors (PPIs), including Dexilant, has been associated with a possible increased risk of bone fractures (hip, wrist, and spine) in some individuals. This may be due to reduced calcium absorption. Your doctor will assess your risk factors for osteoporosis before and during treatment.
• Other medications you are taking: Dexilant can potentially reduce the effectiveness of clopidogrel (Plavix). This occurs because dexlansoprazole can inhibit the CYP2C19 enzyme, which is necessary to activate clopidogrel. This interaction is clinically significant, and alternative PPIs or antiplatelet therapies may need to be considered, especially in patients at high cardiovascular risk.
• Systemic lupus erythematosus (SLE): There have been rare reports of PPIs triggering or worsening SLE.

Drug Interactions:

Before taking Dexilant, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Dexilant prescribing information.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Dexilant. Dexilant may interact with other medicines, but is not limited to:

Drugs that should generally be avoided with Dexilant:
• Acalabrutinib: Dexilant can decrease the levels of acalabrutinib, a medication for blood cancer, by increasing gastric pH.
• Atazanavir: Dexilant can decrease the absorption of atazanavir, another HIV medication, by increasing stomach pH.
• Certain Tyrosine Kinase Inhibitors: Dexilant can significantly reduce the effectiveness of cancer medications like dasatinib and nilotinib by increasing stomach pH, affecting their absorption. This can lead to suboptimal cancer treatment outcomes.
• Erlotinib: Dexilant can decrease the levels of erlotinib, a cancer medication, by increasing gastric pH • Rilpivirine-containing products: Dexilant can significantly lower the levels of rilpivirine, an HIV medication, making it less effective. Examples include Cabenuva, Juluca, Odefsey, and Complera.

Drugs that may have increased effects or risk of side effects when taken with Dexilant:
• Digoxin: Dexilant can increase digoxin levels, and it is a medication used for heart conditions, potentially leading to side effects.
• Methotrexate: Dexilant can interfere with the breakdown of methotrexate, a drug used for cancer and autoimmune conditions, increasing the risk of side effects.
• Tacrolimus: Dexilant can increase the levels of tacrolimus, an immunosuppressant used after organ transplants, raising the risk of side effects.
• Warfarin: Dexilant can increase the effects of warfarin, a blood thinner, potentially leading to an increased risk of bleeding.

Drugs that may be less effective when taken with Dexilant:
• Certain Antifungals: Dexilant can reduce the absorption and effectiveness of certain antifungal medications like ketoconazole and itraconazole by increasing gastric pH, as these drugs require an acidic environment for optimal absorption. Unlike other antifungals, fluconazole's absorption is generally not significantly impacted by changes in gastric pH caused by Dexilant.
• Certain Antibiotics: As Dexilant alters gastric pH, the absorption of pH-dependent medications may be affected. Always consult your doctor or pharmacist to review all concurrent medications for potential interactions.
• Mycophenolate Mofetil: Dexilant can make mycophenolate mofetil, an immunosuppressant, less effective.

Drugs that should generally be avoided:
• Iron Supplements: Dexilant can reduce the absorption of iron supplements by decreasing stomach acid, which is needed to convert iron into a more absorbable form.
• St. John's Wort and Rifampin: St. John's Wort and rifampin are strong inducers of liver enzymes (including CYP3A4 and potentially CYP2C19) that metabolize dexlansoprazole, which may decrease its effectiveness and should generally be avoided.
• Voriconazole: This medication can increase the levels of dexlansoprazole in your body. Your doctor may need to adjust your dexlansoprazole dosage if you are taking voriconazole.

Alcohol
While alcohol doesn't directly interact with how Dexilant works, it can worsen the symptoms of conditions like GERD and erosive esophagitis that Dexilant treats by potentially relaxing the lower esophageal sphincter and increasing stomach acid production. Therefore, it is generally recommended to avoid or limit alcohol consumption while taking this medication.

Pregnancy and Breastfeeding

While some studies on proton pump inhibitors (PPIs) have not shown a significantly increased risk of major birth defects, the safety of Dexilant during pregnancy needs careful evaluation. It is crucial to discuss your specific situation with your doctor, who can assess the risks and benefits. It is important to consult with your doctor about whether Dexilant passes into breast milk and the potential effects on your nursing infant. They can help you make the safest choice for you and your baby.

Frequently Asked Questions about Dexilant at Canada Pharmacy Online:

Why is Dexilant more affordable in Canada than in the United States?

Prescription drug prices, including Dexilant, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Dexilant 30 mg and 60 mg?

The difference in dosage represents the different amount of the same active ingredient (dexlansoprazole) present in each capsule.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many capsules I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Dexilant at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Dexilant requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Dexilant?

Yes, there is a generic alternative for this product called dexlansoprazole.

How long should I take Dexilant?

The duration of treatment with Dexilant depends on the condition being treated. Erosive esophagitis usually takes up to 8 weeks to heal and 6 months to maintain. For GERD, it is typically taken for 4 weeks. Your doctor will determine the appropriate length of treatment for you.

Blog Post

Did My Stomach Fall Asleep on the Job?
Gastroparesis: Dietary Tips to Reverse Your Life

Latest News

Diagnosis and Management of Gastroesophageal Reflux Disease: A Concise Review for Clinicians (study published in May 2025)

Similar Drugs in the category of Antacid/Proton Pump Inhibitors :

Nexium Aciphex Protonix Prevacid Gaviscon

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

Reviews From Real Customers