Protonix (Pantoprazole Sodium)

Name: Protonix
Brand: Takeda
SKU: 1918
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Protonix

Manufacturer: Takeda

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Protonix

Manufacturer: Nycomed

Country: Australia

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Protonix

Manufacturer: Brand

Country: Turkey

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Protonix

Manufacturer: Takeda

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Protonix

Manufacturer: Takeda

Country: Australia

Dosage: 40 mg

Qty-Price (USD):

Generic Equivalent of Protonix

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Pantoprazole Sodium

Manufacturer: Generic

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Pantoprazole Sodium

Manufacturer: Generic

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Pantoprazole Sodium

Manufacturer: Generic

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Pantoprazole Sodium

Manufacturer: Generic

Country: India

Dosage: 40 mg

Qty-Price (USD):

Protonix Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on September 3, 2025.

Protonix and Pantoprazole at CanadaPharmacyOnline.com

Protonix (pantoprazole) is available under various brand names globally. In Canada, it is distributed and marketed by Takeda under the brand name Pantoloc. It is also manufactured by Nycomed (or Takeda) in Australia and by Bayer in Turkey, under the names Somac and Pantpas.

Generic pantoprazole is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Protonix:

Generic pantoprazole contains the same active ingredient as the brand-name Protonix and is required to meet the same safety, effectiveness, and quality standards as the brand-name product. This means it's designed to work in the same way as pantoprazole, also known as Protonix. Studies have demonstrated bioequivalence between generic and brand-name pantoprazole, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic pantoprazole, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage

Protonix and generic pantoprazole are available as delayed-release oral tablets in 20 mg and 40 mg strengths.

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage

Protonix (pantoprazole) is a prescription medication used to treat a variety of gastrointestinal issues, including:
• Duodenal Ulcer and Gastric Ulcer: Typically used in combination therapy, or for treatment of ulcers not associated with H. pylori.
• Helicobacter pylori Eradication: Used in combination with antibiotics to eliminate H. pylori bacteria, which can cause stomach ulcers.
• Maintenance of Healing of Erosive Esophagitis: To keep the esophagus healed and reduce the relapse rates of heartburn symptoms in adults with GERD.
• Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome: Long-term treatment of conditions where the stomach produces too much acid.
• Prevention of Gastrointestinal Lesions Induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): For patients who need continuous NSAID treatment and are at an increased risk of developing upper gastrointestinal lesions.
• Short-Term Treatment of Erosive Esophagitis Associated with Gastroesophageal Reflux Disease (GERD): Healing and symptomatic relief of damage to the esophagus caused by stomach acid.
• Symptomatic Gastroesophageal Reflux Disease (e.g., acid regurgitation and heartburn): Relief of these symptoms. For symptomatic relief without erosive esophagitis, use should be short-term and at the lowest effective dose.

Mechanism of Action
Protonix (pantoprazole) is a proton pump inhibitor (PPI). It works by irreversibly binding to the H+/K+-ATPase enzyme system, also known as the proton pump, which is located on the secretory surface of gastric parietal cells in the stomach. This enzyme is the final step in the production of gastric acid. By blocking this pump, pantoprazole effectively suppresses both basal (constant) and stimulated (triggered by food) gastric acid secretion, regardless of the stimulus. Because the binding is covalent and irreversible, new proton pumps must be synthesized before acid production can resume, leading to a prolonged anti-secretory effect that can last for more than 24 hours.

Take Protonix exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Protonix, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Protonix, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Protonix; other side effects may also occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Abdominal pain
• Arthralgia (joint pain)
• Diarrhea
• Dizziness
• Flatulence (gas)
• Headache
• Nausea
• Vomiting

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Severe rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, wheezing, and itching.
• Clostridium difficile-associated diarrhea (CDAD): Severe, watery, or bloody diarrhea that does not improve, fever, abdominal pain, and cramping. The risk is increased with the use of PPIs.
• Community-Acquired Pneumonia (CAP): Some studies suggest a possible increased risk of CAP, particularly early in treatment
• Hypomagnesemia (low magnesium levels in the blood): characterized by symptoms such as muscle spasms, tremors, muscle cramps, weakness, irregular heartbeat, seizures, or dizziness. More common with prolonged use (three months or more).
• Increased Risk of Bone Fractures/Osteoporosis: Increased risk of hip, wrist, or spine fractures, particularly with high doses or long-term use (one year or more). Patients at risk of osteoporosis should be monitored.
• Kidney problems (Acute Interstitial Nephritis): Signs include a change in frequency of urination or amount of urine, blood in the urine, fever, joint pain, loss of appetite, nausea, skin rash, swelling of the body, feet, or ankles, malaise, unusual tiredness or weakness, or unusual weight gain.
• Lupus erythematosus (cutaneous or systemic): New or worsening joint pain, fatigue, malar rash (butterfly rash), skin rash on cheeks or arms that worsens in sunlight.
• Masking of Gastric Malignancy: Symptomatic response to pantoprazole therapy does not rule out the presence of gastric malignancy. Consider further evaluation (e.g., endoscopy) in adult patients with a suboptimal response to treatment or early symptomatic relapse after completing treatment, or those with alarm symptoms (e.g., unexplained weight loss, recurrent vomiting, dysphagia, hematemesis, melena).
• Microscopic Colitis: May cause or worsen symptoms such as watery diarrhea (which may be severe) with abdominal pain, especially after several weeks or months of treatment.
• Polyps: Using this medication for an extended period may cause the development of growths (fundic gland polyps) in the stomach. They usually don't cause any symptoms and are generally not cancerous.
• Severe Skin Reactions: Redness, blistering, peeling, or loosening of the skin, including inside the mouth (e.g., Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), or Acute Generalized Exanthematous Pustulosis (AGEP)).
• Vitamin B12 deficiency: Long-term use (more than three years) may lead to vitamin B12 deficiency. Symptoms can include numbness or tingling in the hands or feet, muscle weakness, confusion, or memory problems.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Protonix, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Protonix should not be used if:
• You are allergic to pantoprazole, other proton pump inhibitors (PPIs) (e.g., omeprazole, lansoprazole), or any other ingredient in Protonix. • You are taking any products containing rilpivirine (an antiretroviral drug). Concomitant use is contraindicated.

Tell your doctor about all of your medical conditions, past and present, before starting Protonix. This is crucial because certain conditions affect whether Protonix is right for you. These conditions may include, but are not limited to:
• Any unexplained weight loss, recurrent vomiting, difficulty swallowing (dysphagia), blood in vomit (hematemesis), or black, tarry stools (melena). These could be signs of a serious underlying condition.
• Any unusual or allergic reaction to pantoprazole or other medications
• History of low magnesium levels (hypomagnesemia)
• History of seizures
• If you have diarrhea, especially if it's severe or persistent
• Kidney problems
• Liver disease (may require dose adjustment)
• Osteoporosis and risk factors for bone fractures
• Systemic lupus erythematosus (SLE)

Drug Interactions

Before taking Protonix, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information from Pfizer at https://labeling.pfizer.com/showlabeling.aspx?id=135.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Protonix. Protonix may interact with other medicines, but is not limited to:
• Antiretroviral drugs (e.g., atazanavir, nelfinavir, rilpivirine): Protonix can significantly reduce the absorption of certain antiretrovirals, making them less effective. Concomitant use with rilpivirine is contraindicated.
• Clopidogrel (antiplatelet): Protonix is considered to have a lower risk of interaction with clopidogrel compared to some other PPIs (e.g., omeprazole), but may still reduce its effectiveness. Your doctor will assess the risk and may consider an alternative acid-reducing medication or alternative antiplatelet therapy.
• Digoxin: Increased absorption of digoxin can occur.
• Diuretics (thiazide or loop diuretics): Increased risk of hypomagnesemia.
• Drugs that depend on gastric pH for absorption (e.g., ketoconazole, itraconazole, erlotinib, iron salts, ampicillin esters, mycophenolate mofetil): Protonix decreases stomach acid, which can reduce the absorption and effectiveness of these medications.
• Methotrexate: Concomitant use, especially with high-dose methotrexate, may increase methotrexate levels and its toxicity. A temporary withdrawal of the PPI may be considered.
• Oral Contraceptives: Pantoprazole can increase the exposure to certain oral contraceptives.
• St. John's Wort: May reduce the effectiveness of pantoprazole.
• Warfarin (blood thinner): Increased risk of bleeding. Close monitoring of INR (International Normalized Ratio) is recommended.

Pregnancy and Breastfeeding

Protonix should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. While animal studies have shown some effects on fetal bone development, human data from observational studies generally do not indicate an increased risk of major congenital malformations with pantoprazole. However, Protonix should be used during pregnancy only if needed and the potential benefit justifies the potential risk to the fetus.

Pantoprazole is excreted in human milk. A decision should be made whether to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor for personalized advice.

Use in the Elderly

No overall differences in safety or effectiveness have been observed between elderly and younger patients. However, elderly patients may be at an increased risk for specific side effects, such as Clostridium difficile infection, bone density loss, pneumonia, and low magnesium levels. No dosage adjustment is typically needed based solely on age, but caution and close monitoring are advisable.

Use in Children

Protonix is indicated for short-term treatment of erosive esophagitis associated with GERD in pediatric patients aged 5 years and older. The safety of treatment beyond 8 weeks in pediatric patients has not been established. For children under 5 years, use and dosage must be determined by a doctor. Pediatric patients who are CYP2C19 poor metabolizers may exhibit significantly lower drug clearance, and a dose reduction should be considered for them. Long-term use in pediatric patients should be avoided unless necessary, due to potential risks such as bone fractures and hypomagnesemia.

Frequently Asked Questions about Protonix at Canada Pharmacy Online:

Why is Protonix more affordable in Canada than in the United States?

Prescription drug prices, including Protonix, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Protonix at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Protonix requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the best time to take Protonix?

Protonix is usually taken once daily, typically about 30 minutes before a meal. It's important to swallow the delayed-release tablet whole and not crush, chew, or split it. For Zollinger-Ellison syndrome or other hypersecretory conditions, it may be taken twice daily. Follow your doctor's specific instructions.

Blog Posts:

Did My Stomach Fall Asleep on the Job?
Good for Gut Health? White Rice Vs Brown Rice

Latest News:

Sex-specific association of visceral and abdominal subcutaneous adipose tissue with gastroesophageal reflux disease: a large-scale perspective cohort study (article published on September 2, 2025)

Similar Drugs in the category of Antacid/Proton Pump Inhibitors :

Dexilant Nexium Aciphex Prevacid Gaviscon

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

Reviews From Real Customers